CAZyme Information: MGYG000002939_02667

Basic Information

• Species: Enterococcus_A sp002140655
• Lineage: Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae; Enterococcus_A; Enterococcus_A sp002140655
• CAZyme ID: MGYG000002939_02667
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
350		39697.14	9.3858

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002939	2985142	MAG	Russia	Europe

• Gene Location: Start: 1293; End: 2345 Strand: +

Full Sequence      

MANRKERHQQKKEKRIRPARKKSSQSKLSRSTKISLSILAAILLVVIAGTIFFFQKYGKE
VIAAIDAGEEHAAKIQESDFKQYHPTTILDKNGQVLKELKTQERDYITYDKMDPLVSQAL
ISIEDKRFYDHHGVDTQGLLTVALNAATGRGVRGASTITQQLVKNIYLTPEVSISRKIEE
MVMAQSLEKKFTKHQILEYYLNNVYFGHGAYGINAAAKVYFGKSINDTSLLEKATLVGIT
NNPGIFDPTTNKKNALKRAKLILKEMNQQGYITKDQYDKAVADDISAEIHSNALNNQLDN
NEVALAVDSTTKILMGQQDFRFQYQFDSKEEEDRYNEEYTTAYNLSLIHI

Enzyme Prediction     

No EC number prediction in MGYG000002939_02667.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	93	267	9.7e-66	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam00912	Transgly	3.82e-81	92	267	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
COG0744	MrcB	2.76e-79	42	285	12	259	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	2.48e-78	104	285	2	184	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	2.24e-72	38	293	10	257	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	4.09e-55	36	291	7	254	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QXJ61099.1	6.45e-219	1	344	1	344
QZO10429.1	1.83e-218	1	344	1	344
QCQ11338.1	3.08e-207	1	344	1	344
AXG40260.1	1.19e-203	1	344	1	344
AFV21847.1	7.03e-79	54	344	51	343

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2OQO_A	8.64e-48	90	281	6	198	Crystalstructure of a peptidoglycan glycosyltransferase from a class A PBP: insight into bacterial cell wall synthesis [Aquifex aeolicus VF5],3D3H_A Crystal structure of a complex of the peptidoglycan glycosyltransferase domain from Aquifex aeolicus and neryl moenomycin A [Aquifex aeolicus],3NB7_A Crystal structure of Aquifex Aeolicus Peptidoglycan Glycosyltransferase in complex with Decarboxylated Neryl Moenomycin [Aquifex aeolicus]
3NB6_A	3.40e-47	90	281	6	198	Crystalstructure of Aquifex aeolicus peptidoglycan glycosyltransferase in complex with Methylphosphoryl Neryl Moenomycin [Aquifex aeolicus]
3UDF_A	2.00e-39	85	296	20	232	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
5ZZK_A	8.55e-39	106	282	59	242	ChainA, Monofunctional glycosyltransferase [Staphylococcus aureus subsp. aureus Mu50]
3HZS_A	8.65e-39	106	282	23	206	ChainA, Monofunctional glycosyltransferase [Staphylococcus aureus subsp. aureus MW2]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P02918	1.42e-44	79	291	41	254	Penicillin-binding protein 1A OS=Escherichia coli (strain K12) OX=83333 GN=mrcA PE=1 SV=1
O66874	2.49e-43	88	281	47	241	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
P39793	1.44e-41	72	280	63	273	Penicillin-binding protein 1A/1B OS=Bacillus subtilis (strain 168) OX=224308 GN=ponA PE=1 SV=1
O87626	2.07e-41	80	288	44	253	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
A7GHV1	3.08e-41	85	330	56	310	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999882	0.000131	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
34	53