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CAZyme Information: MGYG000002941_00134
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Actinomyces graevenitzii | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Actinomycetaceae; Actinomyces; Actinomyces graevenitzii | |||||||||||
| CAZyme ID | MGYG000002941_00134 | |||||||||||
| CAZy Family | GH101 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 10241; End: 15712 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH101 | 47 | 725 | 2.6e-164 | 0.9787835926449788 |
| CBM51 | 1160 | 1303 | 2.2e-35 | 0.9776119402985075 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam12905 | Glyco_hydro_101 | 1.18e-128 | 300 | 574 | 1 | 273 | Endo-alpha-N-acetylgalactosaminidase. Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolize the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein Endo-alpha-N-acetylgalactosaminidase, where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor. |
| cd14244 | GH_101_like | 1.26e-122 | 315 | 597 | 3 | 298 | Endo-a-N-acetylgalactosaminidase and related glcyosyl hydrolases. This family contains the enzymatically active domain of cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins (EC:3.2.1.97). It has been classified as glycosyl hydrolase family 101 in the Cazy resource. Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae and other commensal human bacteria is largely determined by their ability to degrade host glycoproteins and to metabolize the resultant carbohydrates. |
| pfam18080 | Gal_mutarotas_3 | 8.19e-64 | 43 | 299 | 1 | 243 | Galactose mutarotase-like fold domain. This domain is found in endo-alpha-N-acetylgalactosaminidase present in Streptococcus pneumoniae. Endo-alpha-N-acetylgalactosaminidase is a cell surface-anchored glycoside hydrolase involved in the breakdown of mucin type O-linked glycans. The domain, known as domain 2, exhibits strong structural similarlity to the galactose mutarotase-like fold but lacks the active site residues. Domains, found in a number of glycoside hydrolases, structurally similar to domain 2 confer stability to the multidomain architectures. |
| pfam08305 | NPCBM | 2.26e-37 | 1158 | 1304 | 2 | 135 | NPCBM/NEW2 domain. This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.) |
| smart00776 | NPCBM | 5.02e-32 | 1155 | 1304 | 1 | 144 | This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| VEG53803.1 | 0.0 | 9 | 1695 | 8 | 1651 |
| QQM68206.1 | 0.0 | 9 | 1683 | 8 | 1644 |
| QQO77976.1 | 0.0 | 9 | 1674 | 14 | 1640 |
| AVM61293.1 | 0.0 | 9 | 1674 | 14 | 1640 |
| ASN19565.1 | 1.69e-284 | 43 | 1317 | 58 | 1317 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6QFO_A | 1.02e-105 | 39 | 1039 | 8 | 1120 | EngBFDARPin Fusion 9b 3G124 [Bifidobacterium longum] |
| 6QEP_A | 3.01e-105 | 39 | 1039 | 8 | 1120 | EngBFDARPin Fusion 4b H14 [Bifidobacterium longum] |
| 2ZXQ_A | 3.91e-105 | 39 | 1039 | 23 | 1135 | Crystalstructure of endo-alpha-N-acetylgalactosaminidase from Bifidobacterium longum (EngBF) [Bifidobacterium longum] |
| 6SH9_B | 5.63e-105 | 41 | 1039 | 10 | 1120 | EngBFDARPin Fusion 4b D12 [Bifidobacterium longum subsp. longum JCM 1217] |
| 6QEV_B | 5.63e-105 | 41 | 1039 | 10 | 1120 | EngBFDARPin Fusion 4b B6 [Bifidobacterium longum] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| A9WNA0 | 3.34e-242 | 42 | 1306 | 51 | 1305 | Putative endo-alpha-N-acetylgalactosaminidase OS=Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) OX=288705 GN=RSal33209_1326 PE=3 SV=2 |
| Q2MGH6 | 5.56e-91 | 41 | 1041 | 332 | 1424 | Endo-alpha-N-acetylgalactosaminidase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=SP_0368 PE=1 SV=1 |
| Q8DR60 | 2.95e-90 | 41 | 1041 | 332 | 1424 | Endo-alpha-N-acetylgalactosaminidase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=spr0328 PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.001802 | 0.941253 | 0.000590 | 0.055764 | 0.000319 | 0.000243 |
