CAZyme Information: MGYG000002992_01594

Basic Information

• Species: Dorea_A sp900550865
• Lineage: Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Dorea_A; Dorea_A sp900550865
• CAZyme ID: MGYG000002992_01594
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
867		93797.78	5.1652

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002992	2425923	MAG	United States	North America

• Gene Location: Start: 31414; End: 34017 Strand: +

Full Sequence      

MNYGKKKAAKRQKKITSKSTMQGKRIVVRLFKALLICIVLAAVVGVAGGGLFIKKIIDDT
PHVSASDVKPKGFTTFVYADDGSTEIERFVSSGSNRVYKSIDEIPKDLQHAFVAIEDERF
YKHNGIDLQGIARAAVVGITRGNFSEGASTLTQQLIKNNVFPNFTKERTFYDRLQRKIQE
QYLALQIEKKMDKNEIMESYLNTINLGQNCLGVQSASQRYFGKDVSELTLSECAVIAGIT
QSPSTYDPITHPENNTERRNKVLKNMLEQGYISQKQYDEAMADDVYARIQTTNTASQNDN
TYSYFVDALAQQVIQDLKDQLGYTDTQAYNAVYSGGLSIYSTQNQAMQQICDEEANNDSN
YPGLKEYGLDYALTVTRADGSTENYGSNNIKNYVKETTGNDQGLLYSSEDAARAMVEQWK
ATIAQEGDTYDERITITPQPQSSVTIMDQKTGQIKAMVGGRGEKASSLGLNRAYQGSKRQ
PGSTFKILAAYAPALDSCDKTLATTIDDEPYTLKNGQVLRNANKQYGGTTTLREGIKKSI
NVVAVKLSDEITQELGYEYCQKFGISTLVKDKTINGKVFDDSTSQTLALGGITEGVYNYE
MCAAYASIANGGVYNKPTLYSKVVDHDGNVLLDGTGESHTVIKDSTAYLLTSAMEDVVNS
GTGTACQLSNMPVAGKTGTTTSNKDLWFCGFTPYYTCSVWGGYDDNKECDYDTSFRFRLW
KGIMSRIHANLEEKDFKVPSSVEKKSICTITGKIAASGCPSITEYFAKDTLPSDTCSGHG
YSSGSKSKSTTDNDTSDDSTGNSGTTGNYSGNTGGNTGGNTGSDTTGGNTGGDTTGGNTG
GDTTGGNTGSDTTGGNTGGNTGGDTSQ

Enzyme Prediction     

No EC number prediction in MGYG000002992_01594.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	86	266	7.5e-65	0.9661016949152542

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	1.01e-175	95	730	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	1.38e-163	61	737	42	606	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	4.24e-158	24	779	2	771	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	1.26e-91	92	728	143	683	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
PRK11636	mrcA	9.64e-84	96	774	66	830	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QBF72703.1	0.0	1	785	1	789
QRO36088.1	0.0	1	785	1	789
QYX26035.1	0.0	1	785	1	789
QDW73412.1	0.0	1	780	1	780
QEK18344.1	0.0	1	779	1	771

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7U4H_A	7.72e-101	59	772	4	807	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
4OON_A	5.05e-72	77	772	23	768	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3ZG8_B	2.16e-68	186	714	2	443	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3ZG7_B	8.67e-64	186	714	2	443	CrystalStructure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the apo form [Listeria monocytogenes]
3DWK_A	1.51e-63	81	742	12	602	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
A5I6G4	6.60e-113	43	774	26	697	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1
A7FY32	6.60e-113	43	774	26	697	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
A7GHV1	1.20e-112	43	774	26	697	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1
Q891X1	4.27e-108	29	779	18	713	Penicillin-binding protein 1A OS=Clostridium tetani (strain Massachusetts / E88) OX=212717 GN=pbpA PE=3 SV=1
Q97GR5	9.61e-107	80	744	78	683	Penicillin-binding protein 1A OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) OX=272562 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999938	0.000085	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
26	48