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CAZyme Information: MGYG000002997_00613

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Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Lactococcus_A piscium_C
Lineage Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Lactococcus_A; Lactococcus_A piscium_C
CAZyme ID MGYG000002997_00613
CAZy Family GH25
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
367 MGYG000002997_5|CGC1 40271.12 4.9429
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002997 1565244 MAG United States North America
Gene Location Start: 93038;  End: 94141  Strand: -

Full Sequence      Download help

Enzyme Prediction      help


CAZyme Signature Domains help

Family Start End Evalue family coverage
GH25 33 209 1.6e-27 0.9887005649717514

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06415 GH25_Cpl1-like 1.11e-60 30 216 1 195
Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain, thus acting as an enzymatic antimicrobial agent (an enzybiotic) against streptococcal infections. Cpl-1 belongs to the CP family of lysozymes (CPL lysozymes) which includes the Cpl-7 lysin. Cpl-1 has a glycosyl hydrolase family 25 (GH25) catalytic domain with an irregular (beta/alpha)5-beta3 barrel and a C-terminal cell wall-anchoring module formed by six similar choline-binding repeats (ChBr's). The ChBr's facilitate the anchoring of Cpl-1 to the choline-containing teichoic acid of the pneumococcal cell wall. Other members of this domain family have an N-terminal CHAP (cysteine, histidine-dependent amidohydrolases/peptidases) domain similar to that of the firmicute CHAP lysins and associated with endopeptidase activity. The Cpl-7 lysin is also included here as is LysB of Lactococcus phage, and the Mur lysin of Lactobacillus phage.
pfam01183 Glyco_hydro_25 2.09e-21 33 210 1 180
Glycosyl hydrolases family 25.
smart00641 Glyco_25 1.87e-19 115 223 1 109
Glycosyl hydrolases family 25.
cd00118 LysM 1.19e-12 323 366 1 44
Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.
smart00257 LysM 6.86e-11 324 366 1 43
Lysin motif.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
CEN29120.1 1.07e-265 1 367 1 367
QIW51188.1 2.05e-235 1 365 1 365
QIW60345.1 2.91e-235 1 365 1 365
QIW51740.1 1.13e-232 1 365 1 365
QIW56379.1 8.84e-230 1 365 1 365

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1H09_A 1.46e-09 125 203 99 177
ChainA, LYSOZYME [Streptococcus phage Cp1]
1OBA_A 1.47e-09 125 203 100 178
ChainA, Lysozyme [Streptococcus phage Cp1]
2IXU_A 1.47e-09 125 203 100 178
ChainA, LYSOZYME [Streptococcus phage Cp1]
2IXV_A 1.47e-09 125 203 100 178
ChainA, LYSOZYME [Streptococcus phage Cp1],2J8F_A Chain A, LYSOZYME [Streptococcus phage Cp1],2J8G_A Chain A, LYSOZYME [Streptococcus phage Cp1]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q8HA43 9.99e-19 96 216 215 342
D-alanyl-L-alanine endopeptidase OS=Streptococcus phage B30 OX=209152 PE=1 SV=2
P19385 3.41e-09 98 203 73 178
Lysozyme OS=Streptococcus phage Cp-7 OX=10748 GN=CPL7 PE=1 SV=2
P19386 4.50e-09 100 203 75 178
Lysozyme OS=Streptococcus phage Cp-9 OX=10749 GN=CPL9 PE=3 SV=1
P15057 8.04e-09 125 203 100 178
Lysozyme OS=Streptococcus phage Cp-1 OX=10747 GN=CPL1 PE=1 SV=2

SignalP and Lipop Annotations help

This protein is predicted as SP

0.000257 0.998980 0.000195 0.000207 0.000189 0.000170

TMHMM  Annotations      download full data without filtering help

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