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CAZyme Information: MGYG000003042_01850

You are here: Home > Sequence: MGYG000003042_01850

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Gemmiger sp900545545
Lineage Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Ruminococcaceae; Gemmiger; Gemmiger sp900545545
CAZyme ID MGYG000003042_01850
CAZy Family GH36
CAZyme Description Alpha-galactosidase AgaA
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
736 MGYG000003042_12|CGC2 81677.01 5.6956
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003042 2618954 MAG Netherlands Europe
Gene Location Start: 63649;  End: 65859  Strand: -

Full Sequence      Download help

MSICFDESRG  TVHLTNGRIS  YVMQLLDGRY  LLHRYFGPAL  RRWRGTGVPQ  PAKRSYTTEY60
GDTHLYFDAL  PWEFPVAGRG  DYRRPAFSVT  GPSGTPVSEL  LFQGWRVLDK  KPGSDTLPVT120
FAAPGESETL  AVDCVDAVSG  AALTLYYTIF  ADADVIARRQ  RVTNPGTRPL  CLTSLQSVSL180
QLPAGSYDLL  TLYGCHAREA  QQSRAPLHQG  VQAVGSRYGS  SSPRHQPFWA  VLDPAATETA240
GSVYSCMLVY  SGNFNAVVEQ  DAFGAVRAQM  GLGDESFTWT  LAPGETFETP  EALLTYSGQG300
FNGMSHSFHT  VLRRHMLPPR  WQGVPRPVLL  NSWEGMYYDV  SLEKIETQAR  LAKELGMELF360
VLDDGWFRKG  NDSRSSMGDW  TCNTAKLPGG  IEAAADLVHG  LGLKFGLWFE  PEAVSRESDL420
YRAHPDWILQ  VPGLDPREGR  HEYLLDLSRA  EVRRYLLDVL  HRYLGTGKID  YIKWDMNRPL480
TDAASAALPA  HRQGEVPHRY  VLGLYEILRE  ITQSYPQVLF  EGCSSGGARL  DAGMLAYFAQ540
NWTSDNTDAR  DRTDIQAGFS  LLYPPEVLGA  HVSITPNHQT  GRTTPLETRF  AVARLFNLGY600
ELDLTRCTPE  ERAAIAAQVA  TAKAQRNWLM  QGTFWRHPVT  RPGDRMTSVV  SADQSCCLAV660
IFRTLYDPLG  EQAAFQFCGL  DPAREYRDAA  TGEIYGGDEL  MEAGLTLPPC  KQDFAAHSVL720
LCAEEETEYG  HSTADQ736

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap367311014718422025729433136840444147851555258862566269912706GH36
Family Start End Evalue family coverage
GH36 12 706 1.4e-242 0.9956395348837209

CDD Domains      download full data without filtering help

Created with Snap367311014718422025729433136840444147851555258862566269912713GalA286632Melibiase325612GH3629282Glyco_hydro_36N649721Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3345 GalA 2.75e-167 12 713 4 673
Alpha-galactosidase [Carbohydrate transport and metabolism].
pfam02065 Melibiase 4.19e-163 286 632 1 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
cd14791 GH36 6.38e-132 325 612 1 287
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 1.86e-82 29 282 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 1.19e-15 649 721 6 78
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap36731101471842202572943313684044414785155525886256626995718ATO44275.1|GH365718ATO55962.1|GH365718QEA53344.1|GH363720SON66029.1|GH363720ASN13389.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
ATO44275.1 1.10e-233 5 718 4 719
ATO55962.1 6.29e-233 5 718 4 719
QEA53344.1 5.07e-232 5 718 4 719
SON66029.1 1.53e-225 3 720 2 718
ASN13389.1 1.53e-225 3 720 2 718

PDB Hits      download full data without filtering help

Created with Snap367311014718422025729433136840444147851555258862566269917144FNR_A17144FNQ_A17144FNP_A17144FNU_A17144FNT_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
4FNR_A 4.59e-200 1 714 1 717
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNQ_A 1.84e-199 1 714 1 717
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNP_A 4.16e-198 1 714 1 717
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]
4FNU_A 4.16e-198 1 714 1 717
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]
4FNT_A 5.88e-198 1 714 1 717
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap36731101471842202572943313684044414785155525886256626991714sp|Q9ALJ4|AGAA_GEOSE3716sp|G1UB44|MELA_LACAC3714sp|P43467|AGAL1_PEDPE1717sp|G4T4R7|AGASK_RUMGN1722sp|P43469|AGAL2_PEDPE
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9ALJ4 2.52e-199 1 714 1 717
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G1UB44 5.38e-185 3 716 6 723
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 6.30e-181 3 714 4 720
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
G4T4R7 5.28e-171 1 717 1 713
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
P43469 2.05e-169 1 722 1 717
Alpha-galactosidase 2 OS=Pediococcus pentosaceus OX=1255 GN=agaS PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000063 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003042_01850.