CAZyme Information: MGYG000003051_01136

Basic Information

• Species: Collinsella sp900542965
• Lineage: Bacteria; Actinobacteriota; Coriobacteriia; Coriobacteriales; Coriobacteriaceae; Collinsella; Collinsella sp900542965
• CAZyme ID: MGYG000003051_01136
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
574		60969.52	4.3053

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003051	2082654	MAG	Netherlands	Europe

• Gene Location: Start: 23509; End: 25233 Strand: -

Full Sequence      

MREAYIAVKMEDMYSKDEILMMYLNTIYYGHGAYGIEAAAETYLSKSAADLTLSEAALLI
GLPNSPSQYDPTVNPDLALSRRNKVLDNMLRLGHITQEEHDAAQAEPITLNVTEISGSGV
DVYSQPYFVAYVKQLLEQEFSTDVLFKGGLTVKTTIDPTMQQVAENAVREQLDTLSLDGL
DMGMVVVDPKTGYIKCMVGGYDYNADENHVNHATAKRPVGSTFKAFTLATAIQNGMNPNV
TLNCNSPLKAKGTTTEVQNYANHSYGNITLKQATAYSSNTGYIQVAEAVGNSKIISLVKK
LGIDPAKDNIEDVPVMTLGTGSISPLEMAAAYATFANGGYYRQPIAITEIDSRTGSVLYQ
HTDNPSQVLTEGEAAAVTDVLSGVMQGGGTGAAGALSVNQPYAGKTGTTDNTTNLWFCGY
TPQLACALWTGYSAGEIPIQKYGTDLLGDSTNLPVFKRFMNTVLTGTEREEFATGTAPTY
KNNSVWKFYGTNNSKKTENDDKDKNEDEEETTTTTTTTTTTTETTGGDTTGGTGTTGGST
GGSTGGSTGGDGGTPTPTPTPTPDPSPTPDDTVG

Enzyme Prediction     

No EC number prediction in MGYG000003051_01136.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	1	89	1e-33	0.4971751412429379

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	2.47e-150	2	464	78	529	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	4.68e-141	2	472	153	605	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	2.05e-117	2	473	143	728	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
PRK09506	mrcB	2.23e-59	2	460	287	743	bifunctional glycosyl transferase/transpeptidase; Reviewed
COG4953	PbpC	2.98e-56	1	431	132	534	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QIA33680.1	0.0	2	537	160	695
AZH69246.1	0.0	2	537	160	695
ATP53936.1	0.0	2	496	160	654
AEB07395.1	5.11e-203	2	490	160	648
QWT17307.1	5.04e-187	2	488	160	646

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3ZG8_B	3.30e-56	9	432	2	432	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3ZG7_B	2.93e-51	9	432	2	432	CrystalStructure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the apo form [Listeria monocytogenes]
4OON_A	7.64e-50	3	464	116	723	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	9.92e-49	3	467	116	719	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
5FGZ_A	3.48e-47	3	460	233	690	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P70997	9.31e-70	3	432	151	581	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
O66874	2.91e-62	2	472	139	676	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
P38050	3.53e-56	2	432	143	570	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
A0R7G2	2.92e-55	2	476	211	696	Penicillin-binding protein 1A OS=Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) OX=246196 GN=ponA1 PE=3 SV=1
Q00573	1.80e-52	2	439	150	607	Penicillin-binding protein 1A (Fragment) OS=Streptococcus oralis OX=1303 GN=ponA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000084	0.000001	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000003051_01136.