CAZyme Information: MGYG000003058_00418

Basic Information

• Species: UBA7001 sp900553685
• Lineage: Bacteria; Firmicutes_A; Clostridia; TANB77; CAG-508; UBA7001; UBA7001 sp900553685
• CAZyme ID: MGYG000003058_00418
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
233	MGYG000003058_2|CGC2	26789.57	4.6696

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003058	1822100	MAG	United States	North America

• Gene Location: Start: 105147; End: 105848 Strand: -

Full Sequence      

MKKLLKRILIFIVTIGVIAGGVLTYQGYTMYKEAITETSISDKIEEIKDATEYYTEFETL
PDDYVHAVIAVEDRRFFEHNGIDLISIARAVIKDIQTMSLAEGGSTITQQLAKNTYFTQK
KEFTRKIAEVFMAFEFEKECSKEEIFELYVNTMYFGDGYYNIHDAAEGYFDKEVQDMSLY
ESTLLAGIPNAPSVYSPTKNPDLAKQRHAQVLSKMVKYKYITQEEADKILNEM

Enzyme Prediction     

No EC number prediction in MGYG000003058_00418.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	43	216	1.5e-61	0.9774011299435028

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam00912	Transgly	4.05e-78	44	216	5	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
COG0744	MrcB	5.25e-72	1	232	7	257	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	6.20e-67	1	232	1	247	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	8.20e-48	60	232	74	246	penicillin-binding protein 1a; Provisional
PRK13481	PRK13481	2.04e-40	2	233	5	232	glycosyltransferase; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
SET89048.1	5.00e-85	5	233	7	234
QUO38940.1	2.90e-83	1	230	4	232
QNM09777.1	1.88e-81	7	230	19	241
ADL05597.1	1.56e-79	19	233	2	215
ASB42272.1	1.25e-76	3	227	12	235

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3NB6_A	3.09e-45	53	232	21	200	Crystalstructure of Aquifex aeolicus peptidoglycan glycosyltransferase in complex with Methylphosphoryl Neryl Moenomycin [Aquifex aeolicus]
2OQO_A	1.23e-44	53	232	21	200	Crystalstructure of a peptidoglycan glycosyltransferase from a class A PBP: insight into bacterial cell wall synthesis [Aquifex aeolicus VF5],3D3H_A Crystal structure of a complex of the peptidoglycan glycosyltransferase domain from Aquifex aeolicus and neryl moenomycin A [Aquifex aeolicus],3NB7_A Crystal structure of Aquifex Aeolicus Peptidoglycan Glycosyltransferase in complex with Decarboxylated Neryl Moenomycin [Aquifex aeolicus]
3UDF_A	8.56e-40	23	232	10	219	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
4OON_A	1.91e-39	57	232	44	219	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
5U2G_A	1.89e-34	60	232	48	220	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O87579	7.13e-44	54	232	70	248	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
O05131	4.71e-43	54	232	70	248	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae OX=485 GN=mrcA PE=1 SV=3
P0A0Z5	4.71e-43	54	232	70	248	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) OX=122587 GN=mrcA PE=3 SV=1
Q5FAC7	4.71e-43	54	232	70	248	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) OX=242231 GN=mrcA PE=3 SV=3
P0A0Z6	4.71e-43	54	232	70	248	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup B (strain MC58) OX=122586 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.849388	0.127093	0.020180	0.000574	0.000392	0.002389

TMHMM  Annotations     

start	end
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