CAZyme Information: MGYG000003115_02642

Basic Information

• Species: Franconibacter helveticus
• Lineage: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Franconibacter; Franconibacter helveticus
• CAZyme ID: MGYG000003115_02642
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
382		42572.83	8.1717

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003115	3134352	MAG	United States	North America

• Gene Location: Start: 329; End: 1477 Strand: +

Full Sequence      

MSAARPLTIALVAGETSGDILGAGLIRALKAKMPDARFVGVAGPRMQEQGCEAWYDMEEL
AVMGIVEVLGRLRRLLHIRADLTRRFTELKPDVFVGIDAPDFNITLEGNLKKQGIRTIHY
VSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDRFNVPCRFIGHTMADAMPLDPDKNA
ARETLGIAREARCLALLPGSRSAEVEMLSADFLKTAQLLRKVYPELEVVVPLVNAKRREQ
FERIKAEVAPDLPAHLLDGHAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTF
WLAKRLVKTEFVSLPNLLAGRELVKELLQEECEPQKLAAALQPLLADGKQSHEMHDTFRK
LHEQIRCNADEQAALAVLELAR

Enzyme Prediction     

No EC number prediction in MGYG000003115_02642.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	9	366	5.1e-143	0.9943502824858758

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR00215	lpxB	0.0	1	380	1	385	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
COG0763	LpxB	0.0	6	382	1	380	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
PRK00025	lpxB	0.0	6	382	1	376	lipid-A-disaccharide synthase; Reviewed
pfam02684	LpxB	0.0	9	377	1	374	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
PRK01021	lpxB	5.31e-48	11	328	231	551	lipid-A-disaccharide synthase; Reviewed

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ALB61731.1	1.82e-255	5	382	3	380
AHB71684.1	8.63e-254	5	382	3	380
ALX79773.1	8.63e-254	5	382	3	380
ALB51685.1	1.23e-253	5	382	3	380
AGE87496.1	1.23e-253	5	382	3	380

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8N_A	3.69e-243	1	382	1	382	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]
5W8S_A	3.03e-242	1	382	1	382	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
B5F8U3	1.70e-250	1	382	1	382	Lipid-A-disaccharide synthase OS=Salmonella agona (strain SL483) OX=454166 GN=lpxB PE=3 SV=1
A9N0T2	4.88e-250	1	382	1	382	Lipid-A-disaccharide synthase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) OX=1016998 GN=lpxB PE=3 SV=1
B5R421	6.93e-250	1	382	1	382	Lipid-A-disaccharide synthase OS=Salmonella enteritidis PT4 (strain P125109) OX=550537 GN=lpxB PE=3 SV=1
Q57T26	6.93e-250	1	382	1	382	Lipid-A-disaccharide synthase OS=Salmonella choleraesuis (strain SC-B67) OX=321314 GN=lpxB PE=3 SV=1
B5FJ29	6.93e-250	1	382	1	382	Lipid-A-disaccharide synthase OS=Salmonella dublin (strain CT_02021853) OX=439851 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000038	0.000010	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000003115_02642.