CAZyme Information: MGYG000003132_00174

Basic Information

• Species: Dysgonomonas sp900556485
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae; Dysgonomonas; Dysgonomonas sp900556485
• CAZyme ID: MGYG000003132_00174
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
378		43363.38	7.1457

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003132	2983269	MAG	United States	North America

• Gene Location: Start: 188321; End: 189457 Strand: -

Full Sequence      

MKYFLVAGEASGDLHGSNLMAALKKQDPNAEFCFLGGDLMQAQGGRLVKHYREMAFMGFI
PVLLNLRTILRNMKMCQEEIIKFQPDVLILIDYPGFNLKVAKYIKTHTQIPVYYYISPKV
WAWKEYRVKSFKKYVDVMLSILPFEVDFYKKHNYHIDYVGNPVVDAVAQFRDENKGDTQE
KFIEENNLENKPIIALLAGSRQQEIKDNLPAMLESIESFTDYQPVIAGAPAIELDYYKKY
IGDKPCKIVFGQTYRLLEYSEAALVTSGTATLETALFRVPQVVCYETPIPHIVYWVFKNL
LHTKYISLVNLIADKVVVQELFAKFFSVDSIKNEADKLLNDSEYRNNMLSDYDKIINILG
KPGASDHAATIIIEKLKK

Enzyme Prediction     

No EC number prediction in MGYG000003132_00174.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	4	358	1.3e-117	0.9858757062146892

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK00025	lpxB	4.76e-116	1	378	2	377	lipid-A-disaccharide synthase; Reviewed
COG0763	LpxB	1.27e-103	1	378	2	381	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
pfam02684	LpxB	2.54e-77	4	321	2	321	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
TIGR00215	lpxB	2.24e-63	5	321	10	327	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
PRK14089	PRK14089	4.14e-49	1	372	1	344	lipid-A-disaccharide synthase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QIK59046.1	2.81e-212	1	376	1	376
QIK53577.1	6.58e-211	1	376	1	376
ABR44355.1	2.35e-175	1	376	1	375
QRO15504.1	2.35e-175	1	376	1	375
QCY57761.1	2.35e-175	1	376	1	375

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8S_A	1.83e-37	5	321	11	327	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]
5W8N_A	3.54e-37	5	321	11	327	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q1D393	1.11e-64	2	376	6	378	Lipid-A-disaccharide synthase OS=Myxococcus xanthus (strain DK1622) OX=246197 GN=lpxB PE=3 SV=1
Q2LVL8	8.72e-60	5	378	8	380	Lipid-A-disaccharide synthase OS=Syntrophus aciditrophicus (strain SB) OX=56780 GN=lpxB PE=3 SV=1
B6J161	6.10e-58	5	372	8	370	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain CbuG_Q212) OX=434923 GN=lpxB PE=3 SV=1
A9KC41	8.58e-58	5	372	8	370	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain Dugway 5J108-111) OX=434922 GN=lpxB PE=3 SV=1
B6J9H1	8.58e-58	5	372	8	370	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain CbuK_Q154) OX=434924 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000039	0.000007	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000003132_00174.