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CAZyme Information: MGYG000003178_01779

You are here: Home > Sequence: MGYG000003178_01779

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Klebsiella quasivariicola
Lineage Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella; Klebsiella quasivariicola
CAZyme ID MGYG000003178_01779
CAZy Family GH23
CAZyme Description Membrane-bound lytic murein transglycosylase F
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
538 60961.66 6.9841
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003178 3011876 MAG United States North America
Gene Location Start: 1882;  End: 3498  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000003178_01779.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH23 322 475 2.2e-24 0.8444444444444444

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG4623 MltF 0.0 48 517 1 469
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms].
PRK10859 PRK10859 0.0 28 509 1 482
membrane-bound lytic murein transglycosylase MltF.
cd13403 MLTF-like 1.58e-80 322 479 1 160
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins. This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.
cd01009 PBP2_YfhD_N 1.34e-70 70 294 1 223
The solute binding domain of YfhD proteins, a member of the type 2 periplasmic binding fold protein superfamily. This subfamily includes the solute binding domain YfhD_N. These domains are found in the YfhD proteins that are predicted to function as lytic transglycosylases that cleave the glycosidic bond between N-acetylmuramic acid and N-acetylglucosamin in peptidoglycan, while the YfhD_N domain might act as an auxiliary or regulatory subunit. In addition to periplasmic solute binding domain, they have an SLT domain, typically found in soluble lytic transglycosylases, and a C-terminal low complexity domain. The YfhD proteins might have been recruited to create localized cell wall openings required for transport of large substrates such as DNA. They belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
smart00062 PBPb 7.25e-39 71 293 1 219
Bacterial periplasmic substrate-binding proteins. bacterial proteins, eukaryotic ones are in PBPe

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
ASV19049.1 0.0 1 538 1 538
QBL48267.1 0.0 1 538 1 538
QRF13755.1 0.0 1 538 1 538
QHW96046.1 0.0 1 538 1 538
QLP57151.1 0.0 1 538 1 538

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
4OWD_A 2.96e-93 57 474 5 424
Crystalstructure of MltF from Pseudomonas aeruginosa complexed with cysteine [Pseudomonas aeruginosa PAO1],4OXV_A Crystal structure of MltF from Pseudomonas aeruginosa complexed with valine [Pseudomonas aeruginosa PADK2_CF510],4P0G_A Crystal structure of MltF from Pseudomonas aeruginosa complexed with bulgecin and muropeptide [Pseudomonas aeruginosa PAO1],4P11_A Native crystal structure of MltF Pseudomonas aeruginosa [Pseudomonas aeruginosa PAO1]
4OZ9_A 6.72e-93 70 474 11 417
Crystalstructure of MltF from Pseudomonas aeruginosa complexed with isoleucine [Pseudomonas aeruginosa PAO1]
4OYV_A 3.26e-92 57 474 5 424
Crystalstructure of MltF from Pseudomonas aeruginosa complexed with leucine [Pseudomonas aeruginosa PAO1]
5AA4_A 3.70e-92 70 474 4 410
Crystalstructure of MltF from Pseudomonas aeruginosa in complex with cell-wall tetrapeptide [Pseudomonas aeruginosa BWHPSA013],5AA4_C Crystal structure of MltF from Pseudomonas aeruginosa in complex with cell-wall tetrapeptide [Pseudomonas aeruginosa BWHPSA013]
5AA4_B 3.70e-92 70 474 4 410
Crystalstructure of MltF from Pseudomonas aeruginosa in complex with cell-wall tetrapeptide [Pseudomonas aeruginosa BWHPSA013],5AA4_D Crystal structure of MltF from Pseudomonas aeruginosa in complex with cell-wall tetrapeptide [Pseudomonas aeruginosa BWHPSA013]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
A6TCH2 0.0 28 538 1 511
Membrane-bound lytic murein transglycosylase F OS=Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) OX=272620 GN=mltF PE=3 SV=2
B1LP71 6.83e-280 28 529 1 503
Membrane-bound lytic murein transglycosylase F OS=Escherichia coli (strain SMS-3-5 / SECEC) OX=439855 GN=mltF PE=3 SV=1
P0AGC6 3.94e-279 28 529 1 503
Membrane-bound lytic murein transglycosylase F OS=Shigella flexneri OX=623 GN=mltF PE=3 SV=2
B2TXX1 3.94e-279 28 529 1 503
Membrane-bound lytic murein transglycosylase F OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) OX=344609 GN=mltF PE=3 SV=1
B3Y154 3.94e-279 28 529 1 503
Membrane-bound lytic murein transglycosylase F OS=Escherichia coli O111:H- OX=168927 GN=mltF PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.999935 0.000098 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      download full data without filtering help

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33 55