CAZyme Information: MGYG000003273_00118

Basic Information

• Lineage: Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; RUG11200
• CAZyme ID: MGYG000003273_00118
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
655		73264.79	4.3048

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003273	1524353	MAG	El Salvador	South America

• Gene Location: Start: 2067; End: 4034 Strand: -

Full Sequence      

MTWQRKVEEIFIALALEDKYEKFEIMEFYLNNIYFANGYYGIEAASKGYFDCSVTKLDLS
QIAFLCAIPNSPTRYDPVVNIKNTLSRRDRILDQMLEQGFITQDECDSAKAEEIKLNMAK
KIDTDVPNSIVTYITYCSTRAIMQKQGFVFRNDFENDDDKTAYENSYNETYSACQQQLYT
KGYRIYTSIDLKIQKKLQKAVDDNLSKFTDTKDDGIYDMQGAGVCIDNESGRIVAIVGGR
SQKISGYGLNRAYQSYRQPGSAIKPILVYTPAFENGYTPDTKVVDEPIKNGPKNSGGSYA
GTVTMRRAVEKSINTIAWKLYDELIPHNCLKHLVDMNFYKITYDDDYLPASLGGVTYGAT
PVEMASAYAAIENDGVFTTPTCILKVDDAYGHTMIDDNLERKVVYEENAARMMTDVMKGV
LTNGTAAGHEINNMDCAGKTGTTNDKKDGWFVGYTPYYTTSVWCGCDNPKTIDDLWGSSY
PLDIWYDFMTDVHEGLEYKEFTPYEIVSQDDNDSYGGGNHHKDDNNNDSDDDNDEDDSED
NTKAPDENSSKEPDKTKKPQKTDKPKDDASKKPGDKPGNPGKTDEPVSTPSVEPTNEPVT
KEPQTQAPVTDEPADNDAKETPSVTPDTKEPQEEKPQQSSQPESSNEEGAVGEGK

Enzyme Prediction     

No EC number prediction in MGYG000003273_00118.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	2	95	7.8e-32	0.5254237288135594

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	7.06e-145	2	495	72	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	6.01e-136	2	503	147	607	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	6.72e-110	2	503	137	729	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
COG4953	PbpC	3.69e-51	6	489	131	558	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	2.11e-48	2	519	136	816	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BCK01696.1	7.80e-201	1	504	206	706
BBF44496.1	2.83e-200	2	504	160	659
BCN28959.1	1.66e-199	2	505	170	670
BCJ92608.1	1.55e-196	1	505	180	681
CBL14325.1	8.51e-196	2	510	146	652

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3ZG8_B	3.18e-68	16	468	3	434	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3ZG7_B	1.21e-62	16	468	3	434	CrystalStructure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the apo form [Listeria monocytogenes]
3UDF_A	1.77e-52	2	495	109	718	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
7U4H_A	1.98e-51	4	501	110	769	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
4OON_A	6.95e-47	2	489	109	719	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P40750	5.00e-79	2	485	146	616	Penicillin-binding protein 4 OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpD PE=1 SV=2
A5I6G4	3.82e-63	4	500	152	651	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1
A7FY32	3.82e-63	4	500	152	651	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
A7GHV1	5.06e-63	4	500	152	651	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1
P38050	1.79e-61	2	494	137	599	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000038	0.000010	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000003273_00118.