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CAZyme Information: MGYG000003370_00337

You are here: Home > Sequence: MGYG000003370_00337

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Streptococcus mitis_AC
Lineage Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus mitis_AC
CAZyme ID MGYG000003370_00337
CAZy Family CBM40
CAZyme Description Sialidase B
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
697 MGYG000003370_3|CGC1 77713.07 6.4498
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003370 1846494 MAG United States North America
Gene Location Start: 16261;  End: 18354  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

EC 4.2.2.15 3.2.1.18

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH33 232 676 4.5e-76 0.9415204678362573
CBM40 44 225 3.1e-64 0.9720670391061452

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG4409 NanH 0.0 1 697 1 728
Neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis].
pfam02973 Sialidase 1.97e-72 42 227 1 188
Sialidase, N-terminal domain.
cd15482 Sialidase_non-viral 1.06e-53 230 684 1 338
Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
pfam13088 BNR_2 2.18e-13 459 666 82 280
BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.
pfam13385 Laminin_G_3 7.18e-07 95 221 39 151
Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
BBP09272.1 0.0 1 697 1 697
ARD35268.1 0.0 1 697 1 697
AZT87744.1 0.0 1 697 1 697
AFC95267.1 0.0 1 697 1 697
ACO22908.1 0.0 1 697 1 697

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
2VW0_A 0.0 1 697 1 697
Crystalstructure of the NanB sialidase from Streptococcus pneumoniae [Streptococcus pneumoniae],2VW1_A Crystal structure of the NanB sialidase from Streptococcus pneumoniae [Streptococcus pneumoniae],2VW2_A Crystal structure of the NanB sialidase from Streptococcus pneumoniae [Streptococcus pneumoniae],4FOQ_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-aminoethanesulfonic acid [Streptococcus pneumoniae],4FOV_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 3-Cyclohexyl-1-propylsulfonic acid [Streptococcus pneumoniae],4FOW_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 3-ammoniopropane-1-sulfonate [Streptococcus pneumoniae],4FOY_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-(Benzylammonio)ethanesulfonate [Streptococcus pneumoniae],4FP2_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2[(Cyclohexylmethyl)ammonio]sulfonate [Streptococcus pneumoniae],4FP3_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(Furan-2-ylmethyl)ammonio]sulfonate [Streptococcus pneumoniae],4FPC_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPE_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Methoxybenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPF_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Chlorobenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPG_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Hydroxybenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPH_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Fluorobenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPJ_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Methoxybenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPK_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-methylbenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPL_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3,4-dichlorobenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPO_B Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-chloro-4-methoxybenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPY_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Bromobenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FQ4_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Fluoro-3-methylbenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae]
4XE9_A 0.0 39 696 1 658
Crystalstructure of the NanB sialidase from Streptococcus pneumoniae in complex with Optactin [Streptococcus pneumoniae TIGR4],4XHB_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with pentanediol and CHES [Streptococcus pneumoniae TIGR4],4XHX_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin and 2-[(3-Chlorobenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae TIGR4],4XIK_A Crystal structure of NanB sialidase from streptococcus pneumoniae in complex with DMSO [Streptococcus pneumoniae TIGR4],4XIL_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 7.4 in PBS with MPD as the cryoprotectant [Streptococcus pneumoniae TIGR4],4XIO_A Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 8.0 with MPD as the cryoprotectant [Streptococcus pneumoniae TIGR4],4XJ8_A Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 5.0 in 50mM sodium Acetate with DMSO [Streptococcus pneumoniae TIGR4],4XJ9_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 5.0 in 50mM Sodium Acetate with DMSO as the cryoprotectant [Streptococcus pneumoniae TIGR4],4XJA_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 5-acetamido-2,3-difluoro-3-hydroxy-6-[1,2,3-trihydroxypropyl]oxane-2-carboxylic acid [Streptococcus pneumoniae TIGR4],4XJU_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 4-acetamido-2-fluoro-3-hydroxy-6-[1,2-dihydroxyethyl]-7,8-dioxabicyclo[3.2.1]octane-1-carboxylic acid [Streptococcus pneumoniae TIGR4],4XJW_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 7.4 in PBS with DMSO as the cryoprotectant [Streptococcus pneumoniae TIGR4],4XJZ_A Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 7.4 in PBS with DMSO [Streptococcus pneumoniae TIGR4]
4XMA_A 0.0 39 696 1 658
Crystalstructure of the K499G mutant of NanB sialidase from streptococcus pneumoniae in complex with Optactin [Streptococcus pneumoniae TIGR4],4XMI_A Crystal structure of the K499G mutant of NanB sialidase from Streptococcus pneumoniae [Streptococcus pneumoniae TIGR4]
4XOG_A 0.0 37 696 1 660
CRYSTALSTRUCTURE OF THE NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH Optactin and DANA [Streptococcus pneumoniae TIGR4]
4XYX_A 0.0 40 697 1 658
NanBplus Optactamide [Streptococcus pneumoniae]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q54727 0.0 1 697 1 697
Sialidase B OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=nanB PE=1 SV=2
Q27701 3.06e-178 71 696 118 756
Anhydrosialidase OS=Macrobdella decora OX=6405 PE=1 SV=1
P29767 3.88e-50 68 669 220 809
Sialidase OS=Clostridium septicum OX=1504 PE=3 SV=1
P15698 1.62e-06 232 360 41 145
Sialidase OS=Paeniclostridium sordellii OX=1505 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000310 0.998968 0.000231 0.000166 0.000162 0.000144

TMHMM  Annotations      download full data without filtering help

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