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CAZyme Information: MGYG000003378_00170

You are here: Home > Sequence: MGYG000003378_00170

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Chimaeribacter arupi
Lineage Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Chimaeribacter; Chimaeribacter arupi
CAZyme ID MGYG000003378_00170
CAZy Family GH18
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
693 MGYG000003378_6|CGC1 75449.3 4.304
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003378 4918955 MAG United States North America
Gene Location Start: 4299;  End: 6380  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.14

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH18 53 469 2.9e-62 0.9391891891891891

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3325 ChiA 5.09e-116 18 484 3 441
Chitinase, GH18 family [Carbohydrate transport and metabolism].
cd06548 GH18_chitinase 1.85e-96 54 467 1 322
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
smart00636 Glyco_18 4.25e-69 53 467 1 334
Glyco_18 domain.
pfam00704 Glyco_hydro_18 1.53e-58 53 467 1 307
Glycosyl hydrolases family 18.
cd02872 GH18_chitolectin_chitotriosidase 2.54e-37 57 467 4 341
This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QCR37228.1 0.0 1 693 1 703
AEX53502.1 0.0 1 687 1 685
QQN33273.1 0.0 1 687 1 690
AYA08536.1 0.0 1 687 1 686
AZP52421.1 0.0 1 687 1 686

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
6OGD_C 1.55e-113 32 497 130 619
Cryo-EMstructure of YenTcA in its prepore state [Yersinia entomophaga],6OGD_F Cryo-EM structure of YenTcA in its prepore state [Yersinia entomophaga],6OGD_I Cryo-EM structure of YenTcA in its prepore state [Yersinia entomophaga],6OGD_L Cryo-EM structure of YenTcA in its prepore state [Yersinia entomophaga],6OGD_O Cryo-EM structure of YenTcA in its prepore state [Yersinia entomophaga]
4DWS_D 4.29e-112 32 497 43 532
CrystalStructure of a chitinase from the Yersinia entomophaga toxin complex [Yersinia entomophaga]
4DWS_B 6.60e-111 32 497 43 532
CrystalStructure of a chitinase from the Yersinia entomophaga toxin complex [Yersinia entomophaga]
4A5Q_A 9.28e-111 13 515 33 535
Crystalstructure of the chitinase Chi1 fitted into the 3D structure of the Yersinia entomophaga toxin complex [Yersinia entomophaga],4A5Q_B Crystal structure of the chitinase Chi1 fitted into the 3D structure of the Yersinia entomophaga toxin complex [Yersinia entomophaga],4A5Q_C Crystal structure of the chitinase Chi1 fitted into the 3D structure of the Yersinia entomophaga toxin complex [Yersinia entomophaga],4A5Q_D Crystal structure of the chitinase Chi1 fitted into the 3D structure of the Yersinia entomophaga toxin complex [Yersinia entomophaga],4A5Q_E Crystal structure of the chitinase Chi1 fitted into the 3D structure of the Yersinia entomophaga toxin complex [Yersinia entomophaga]
3OA5_A 2.08e-110 13 515 61 563
Thestructure of chi1, a chitinase from Yersinia entomophaga [Yersinia entomophaga],3OA5_B The structure of chi1, a chitinase from Yersinia entomophaga [Yersinia entomophaga]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
B6A879 8.51e-113 32 497 130 619
Chitinase 2 OS=Yersinia entomophaga OX=935293 GN=chi2 PE=1 SV=1
B6A876 4.52e-110 13 515 29 531
Chitinase 1 OS=Yersinia entomophaga OX=935293 GN=chi1 PE=1 SV=1
P32823 1.33e-45 44 677 149 811
Chitinase A OS=Pseudoalteromonas piscicida OX=43662 GN=chiA PE=1 SV=1
P20533 2.42e-39 49 479 41 451
Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1
P07254 2.19e-36 44 482 149 559
Chitinase A OS=Serratia marcescens OX=615 GN=chiA PE=1 SV=3

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000063 0.000006 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003378_00170.