dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000003395_00497

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Basic Information help

Species

Superficieibacter sp900766525

Lineage

Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Superficieibacter; Superficieibacter sp900766525

CAZyme ID

MGYG000003395_00497

CAZy Family

GH23

CAZyme Description

Membrane-bound lytic murein transglycosylase F

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
512		57400.43	6.2597

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003395	5080781	MAG	United States	North America

Gene Location

Start: 141675; End: 143213 Strand: +

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000003395_00497.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH23	291	434	8e-22	0.837037037037037

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG4623	MltF	0.0	28	492	8	471	Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms].
PRK10859	PRK10859	0.0	1	482	1	482	membrane-bound lytic murein transglycosylase MltF.
cd13403	MLTF-like	2.16e-77	295	452	1	160	membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins. This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.
cd01009	PBP2_YfhD_N	1.36e-66	43	267	1	223	The solute binding domain of YfhD proteins, a member of the type 2 periplasmic binding fold protein superfamily. This subfamily includes the solute binding domain YfhD_N. These domains are found in the YfhD proteins that are predicted to function as lytic transglycosylases that cleave the glycosidic bond between N-acetylmuramic acid and N-acetylglucosamin in peptidoglycan, while the YfhD_N domain might act as an auxiliary or regulatory subunit. In addition to periplasmic solute binding domain, they have an SLT domain, typically found in soluble lytic transglycosylases, and a C-terminal low complexity domain. The YfhD proteins might have been recruited to create localized cell wall openings required for transport of large substrates such as DNA. They belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
smart00062	PBPb	7.85e-40	44	266	1	219	Bacterial periplasmic substrate-binding proteins. bacterial proteins, eukaryotic ones are in PBPe

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QGH38164.1	4.88e-259	1	482	1	482
QGH29182.1	4.88e-259	1	482	1	482
QLA07883.1	8.02e-259	1	492	1	492
QLO90161.1	8.02e-259	1	492	1	492
QCU06977.1	8.02e-259	1	492	1	492

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OZ9_A	2.48e-92	39	447	7	417	Crystalstructure of MltF from Pseudomonas aeruginosa complexed with isoleucine [Pseudomonas aeruginosa PAO1]
4OWD_A	3.05e-92	39	447	14	424	Crystalstructure of MltF from Pseudomonas aeruginosa complexed with cysteine [Pseudomonas aeruginosa PAO1],4OXV_A Crystal structure of MltF from Pseudomonas aeruginosa complexed with valine [Pseudomonas aeruginosa PADK2_CF510],4P0G_A Crystal structure of MltF from Pseudomonas aeruginosa complexed with bulgecin and muropeptide [Pseudomonas aeruginosa PAO1],4P11_A Native crystal structure of MltF Pseudomonas aeruginosa [Pseudomonas aeruginosa PAO1]
4OYV_A	8.53e-92	39	447	14	424	Crystalstructure of MltF from Pseudomonas aeruginosa complexed with leucine [Pseudomonas aeruginosa PAO1]
5AA4_B	1.92e-91	43	468	4	434	Crystalstructure of MltF from Pseudomonas aeruginosa in complex with cell-wall tetrapeptide [Pseudomonas aeruginosa BWHPSA013],5AA4_D Crystal structure of MltF from Pseudomonas aeruginosa in complex with cell-wall tetrapeptide [Pseudomonas aeruginosa BWHPSA013]
5AA4_A	1.92e-91	43	468	4	434	Crystalstructure of MltF from Pseudomonas aeruginosa in complex with cell-wall tetrapeptide [Pseudomonas aeruginosa BWHPSA013],5AA4_C Crystal structure of MltF from Pseudomonas aeruginosa in complex with cell-wall tetrapeptide [Pseudomonas aeruginosa BWHPSA013]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
B1LP71	3.30e-257	1	500	1	498	Membrane-bound lytic murein transglycosylase F OS=Escherichia coli (strain SMS-3-5 / SECEC) OX=439855 GN=mltF PE=3 SV=1
B2TXX1	6.64e-257	1	500	1	498	Membrane-bound lytic murein transglycosylase F OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) OX=344609 GN=mltF PE=3 SV=1
B1XB33	6.64e-257	1	500	1	498	Membrane-bound lytic murein transglycosylase F OS=Escherichia coli (strain K12 / DH10B) OX=316385 GN=mltF PE=3 SV=2
B1IVR9	6.64e-257	1	500	1	498	Membrane-bound lytic murein transglycosylase F OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) OX=481805 GN=mltF PE=3 SV=1
B3Y154	6.64e-257	1	500	1	498	Membrane-bound lytic murein transglycosylase F OS=Escherichia coli O111:H- OX=168927 GN=mltF PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999018	0.000138	0.000119	0.000001	0.000001	0.000758

TMHMM Annotations download full data without filtering help

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