CAZyme Information: MGYG000003417_00606

Basic Information

• Species: Firm-11 sp004556545
• Lineage: Bacteria; Firmicutes_A; Clostridia_A; Christensenellales; CAG-74; Firm-11; Firm-11 sp004556545
• CAZyme ID: MGYG000003417_00606
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
920		101122.17	4.9107

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003417	3316884	MAG	Fiji	Oceania

• Gene Location: Start: 11022; End: 13784 Strand: +

Full Sequence      

MFHTHASNDPAQQMQDPYTHTDDPAYQMPENDDSSREGRKKFSIFRPRLSKPNLLISICV
NTLRLFALVIVLGGLALAGAVMGIAKGYMETAPNLDLALLSDQDKTSFLYDTEGNVITDY
KGTENRVMVSIAAMPENLCNAFVAVEDARFYTHNGIDVKRIIGSFVTNFTTGSQQGGSTI
TQQLIKNTVLSSEQSYKRKIQEAYLAMQLESRYTKAQILECYLNTIYLGENYYGVEVAAQ
GYFGKSLSELTLRECAMLAGLTNNPYYYNPRRNFYIRQSETTDYRKLTNNRTDYVLRCMY
ENEFITQAQYQEALNTATANVLETSTTEGDGMYQYAHYVEYAVSDIVDCFLKLNNLEDTS
ENRAKMENELRTGGYRVTLAIDTQIQEIVEDTLDTWTSWPSLRDPSDKVYRTRNNDGTYT
EIEQPQAAAVVLDYRTGELKAIVGSRHRPTQRKTLNRAVNMKMPIGSTIKPIAVYAPAIE
LGASPASVVYNMPIPIKGWTGSDGKDTWPRNYNTGSYAGPETLRNAIRKSNNVSAAQTLM
TMVGVDRSVDFLLRMGVDSDHIDATPYGLSLGSSGITPLQLTVAYGVLANAGVYQQPISF
LGISDSDGNVVYDSHAQQERRQVFRPSTAWMTIDMMKGVISNGTGSAAKIKGQTVAGKTG
TNSDQRGVTFSGMTGWYVSAIWVGHDNYKPLSSKSTGNGSAAPIWQSYMSKIHQAKGLSD
RDIIEATPDQLGIVSATTCAVSGQLATDACRNDSMGYGTVTDYWYEPTVPTVYCQMHQSM
TVCADTGMLATEYCPHTTVKGVVVIPNGHPLSDYVNDPEYGPVIAEYLGTASDYNYCTLH
QDGYSVDNGSYGYNGDLVSDAQQLLQTAYDFMSQLDASSAHYQNVQAAASNLENLLAAGG
ASTADIANAMAQITQAMAGF

Enzyme Prediction     

No EC number prediction in MGYG000003417_00606.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	114	299	1.3e-65	0.9830508474576272

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	1.23e-179	125	714	1	530	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	5.82e-169	45	738	1	622	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	1.32e-143	63	778	9	772	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	3.27e-107	124	713	145	683	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam00912	Transgly	8.26e-78	113	300	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QTE72383.1	0.0	43	919	100	990
QTE73372.1	0.0	43	919	100	990
QUC66968.1	0.0	43	919	100	995
QUA52775.1	0.0	30	919	76	988
QTE69475.1	0.0	10	919	43	958

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7U4H_A	7.64e-75	89	818	2	865	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
4OON_A	1.20e-69	109	746	23	750	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	1.94e-63	109	714	23	717	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3DWK_A	3.96e-56	109	717	10	593	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
5FGZ_A	5.45e-53	124	710	154	691	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q0TNZ8	5.06e-106	63	782	28	729	Penicillin-binding protein 1A OS=Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) OX=195103 GN=pbpA PE=3 SV=1
A7GHV1	2.51e-104	63	805	17	730	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1
A5I6G4	1.96e-103	63	805	17	730	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1
A7FY32	1.96e-103	63	805	17	730	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
Q0SRL7	3.03e-103	89	777	54	724	Penicillin-binding protein 1A OS=Clostridium perfringens (strain SM101 / Type A) OX=289380 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999850	0.000141	0.000001	0.000000	0.000000	0.000009

TMHMM  Annotations     

start	end
63	85