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CAZyme Information: MGYG000003520_00608

You are here: Home > Sequence: MGYG000003520_00608

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species RC9 sp900769145
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; UBA932; RC9; RC9 sp900769145
CAZyme ID MGYG000003520_00608
CAZy Family GH43
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
810 90858.38 5.8343
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003520 2768956 MAG Fiji Oceania
Gene Location Start: 38335;  End: 40767  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000003520_00608.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH43 488 744 1.8e-40 0.8669354838709677

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd16027 SGSH 5.01e-134 46 459 1 373
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase). N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
cd08986 GH43-like 6.08e-107 489 747 1 252
Glycosyl hydrolase family 43 protein; uncharacterized. This glycosyl hydrolase family 43 (GH43)-like subfamily includes uncharacterized enzymes similar to those with beta-1,4-xylosidase (xylan 1,4-beta-xylosidase; EC 3.2.1.37), beta-1,3-xylosidase (EC 3.2.1.-), alpha-L-arabinofuranosidase (EC 3.2.1.55), arabinanase (EC 3.2.1.99), xylanase (EC 3.2.1.8), endo-alpha-L-arabinanase and galactan 1,3-beta-galactosidase (EC 3.2.1.145) activities. These are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many of the enzymes in this family display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.
cd16031 G6S_like 6.42e-76 44 456 1 428
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS). N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
cd16033 sulfatase_like 6.20e-66 46 463 1 411
uncharacterized sulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16022 sulfatase_like 1.60e-62 46 329 1 236
sulfatase. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
CAD72594.1 3.10e-161 22 801 724 1607
AWW33023.1 1.86e-135 477 801 31 373
QDU39553.1 4.31e-135 44 801 29 1022
AGA79989.1 2.92e-134 479 801 33 373
QXD22573.1 3.81e-134 476 801 67 402

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
4MHX_A 2.07e-37 47 464 24 478
ChainA, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MHX_B Chain B, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_A Chain A, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_B Chain B, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_C Chain C, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_D Chain D, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_E Chain E, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_F Chain F, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_G Chain G, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_H Chain H, N-sulphoglucosamine sulphohydrolase [Homo sapiens]
7STT_A 4.16e-34 45 460 6 435
ChainA, N-acetylgalactosamine-6-sulfatase [Pedobacter yulinensis],7STU_A Chain A, N-acetylgalactosamine-6-sulfatase [Pedobacter yulinensis],7STV_A Chain A, N-acetylgalactosamine-6-sulfatase [Pedobacter yulinensis]
5G2V_A 9.72e-30 39 487 22 526
Structureof BT4656 in complex with its substrate D-Glucosamine-2-N, 6-O-disulfate. [Bacteroides thetaiotaomicron VPI-5482]
1E1Z_P 1.64e-25 46 455 3 449
Crystalstructure of an Arylsulfatase A mutant C69S [Homo sapiens]
1E3C_P 1.64e-25 46 455 3 449
Crystalstructure of an Arylsulfatase A mutant C69S soaked in synthetic substrate [Homo sapiens]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
T2KN71 2.33e-56 44 463 45 448
Ulvan-active sulfatase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_22010 PE=1 SV=1
P51688 1.01e-36 47 464 24 478
N-sulphoglucosamine sulphohydrolase OS=Homo sapiens OX=9606 GN=SGSH PE=1 SV=1
T2KN90 1.81e-36 44 478 48 510
Ulvan-active sulfatase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_22210 PE=1 SV=1
Q89YS5 4.95e-29 36 487 43 550
N-acetylglucosamine-6-O-sulfatase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) OX=226186 GN=BT_4656 PE=1 SV=1
P15289 4.47e-24 46 455 21 467
Arylsulfatase A OS=Homo sapiens OX=9606 GN=ARSA PE=1 SV=3

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.001022 0.997375 0.000270 0.000843 0.000255 0.000202

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003520_00608.