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CAZyme Information: MGYG000003565_00964

You are here: Home > Sequence: MGYG000003565_00964

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species UBA3388 sp004551865
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; P3; UBA3388; UBA3388 sp004551865
CAZyme ID MGYG000003565_00964
CAZy Family GH29
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
447 MGYG000003565_37|CGC1 50304.73 5.8545
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003565 1967680 MAG Fiji Oceania
Gene Location Start: 37511;  End: 38854  Strand: -

Full Sequence      Download help

MRIGLNKFFA  VVAALIAFCP  TAEAQIVSDS  SIEYVPTKEN  IASRQEFADA  GFGIFLHWGI60
YSMFAQGEWY  LNRQGVLHEE  YAKAAGGFYP  AGFDAKEWVS  AFKKAGAKYI  CFTTRHHDGF120
SMFATKHSPY  NIVEATPWGK  DVLKELADEC  HRQGIRLHLY  YSLVDWGRDD  YPMGRTGQTT180
GKDKSKADWN  SYCKFMTDQL  TELLTNYGEI  GAIWFDGVWD  HDTDATVFDW  QMRPIYDHIH240
SLQPSCLVAN  NHHLNVSNGE  DIQVFERDLP  GENKGGYSGN  MDISVLPLET  CETMNGIWGY300
RITDQNYKSL  DEIVRLLVGA  AGKGANLLLN  IGPQADGRLP  EIALQRLEQV  GTWLAKYGET360
IYATTAGDLP  VQSWGATTRK  GDRLFVHVWD  DSLRELFLPI  DAKVKSAKDF  ASGEKVKYDR420
CSHGVHLTLP  QKSDTTSPER  VIELQLR447

Enzyme Prediction      help

EC 3.2.1.63

CAZyme Signature Domains help

Created with Snap2244678911113415617820122324526829031233535737940242428362GH29
Family Start End Evalue family coverage
GH29 28 362 1e-100 0.9335260115606936

CDD Domains      download full data without filtering help

Created with Snap2244678911113415617820122324526829031233535737940242434359Alpha_L_fucos34391Alpha_L_fucos57366AfuC94171GHL6
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
pfam01120 Alpha_L_fucos 1.00e-133 34 359 6 333
Alpha-L-fucosidase.
smart00812 Alpha_L_fucos 1.33e-101 34 391 7 373
Alpha-L-fucosidase. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 encompasses alpha-L-fucosidases, which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis.
COG3669 AfuC 7.92e-44 57 366 1 324
Alpha-L-fucosidase [Carbohydrate transport and metabolism].
pfam14871 GHL6 1.41e-06 94 171 1 76
Hypothetical glycosyl hydrolase 6. GHL6 is a family of hypothetical glycoside hydrolases.

CAZyme Hits      help

Created with Snap2244678911113415617820122324526829031233535737940242415445QCD36455.1|GH2934446AVM53983.1|GH291446ADV45083.1|GH291447QJR62590.1|GH291447QJR66848.1|GH29
Hit ID E-Value Query Start Query End Hit Start Hit End
QCD36455.1 6.36e-193 15 445 8 431
AVM53983.1 3.41e-186 34 446 23 432
ADV45083.1 5.55e-186 1 446 1 432
QJR62590.1 1.08e-185 1 447 1 440
QJR66848.1 1.08e-185 1 447 1 440

PDB Hits      download full data without filtering help

Created with Snap22446789111134156178201223245268290312335357379402424454166GN6_A384474PCS_A384472WVS_A384472WVT_A384474WSJ_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
6GN6_A 2.44e-78 45 416 32 407
Alpha-L-fucosidaseisoenzyme 1 from Paenibacillus thiaminolyticus [Paenibacillus thiaminolyticus],6GN6_B Alpha-L-fucosidase isoenzyme 1 from Paenibacillus thiaminolyticus [Paenibacillus thiaminolyticus],6GN6_C Alpha-L-fucosidase isoenzyme 1 from Paenibacillus thiaminolyticus [Paenibacillus thiaminolyticus],6GN6_D Alpha-L-fucosidase isoenzyme 1 from Paenibacillus thiaminolyticus [Paenibacillus thiaminolyticus],6GN6_E Alpha-L-fucosidase isoenzyme 1 from Paenibacillus thiaminolyticus [Paenibacillus thiaminolyticus],6GN6_F Alpha-L-fucosidase isoenzyme 1 from Paenibacillus thiaminolyticus [Paenibacillus thiaminolyticus]
4PCS_A 8.55e-49 38 447 13 436
Crystalstructure of a bacterial fucosidase with iminosugar (2S,3S,4R,5S)-3,4-dihydroxy-2-[2'-phenyl]ethynyl-5-methylpyrrolidine [Bacteroides thetaiotaomicron VPI-5482],4PCS_B Crystal structure of a bacterial fucosidase with iminosugar (2S,3S,4R,5S)-3,4-dihydroxy-2-[2'-phenyl]ethynyl-5-methylpyrrolidine [Bacteroides thetaiotaomicron VPI-5482],4PCS_C Crystal structure of a bacterial fucosidase with iminosugar (2S,3S,4R,5S)-3,4-dihydroxy-2-[2'-phenyl]ethynyl-5-methylpyrrolidine [Bacteroides thetaiotaomicron VPI-5482],4PCS_D Crystal structure of a bacterial fucosidase with iminosugar (2S,3S,4R,5S)-3,4-dihydroxy-2-[2'-phenyl]ethynyl-5-methylpyrrolidine [Bacteroides thetaiotaomicron VPI-5482],4PCT_A Crystal structure of a bacterial fucosidase with iminocyclitol (2S,3S,4R,5S)-3,4-dihydroxy-2-ethynyl-5-methylpyrrolidine [Bacteroides thetaiotaomicron VPI-5482],4PCT_B Crystal structure of a bacterial fucosidase with iminocyclitol (2S,3S,4R,5S)-3,4-dihydroxy-2-ethynyl-5-methylpyrrolidine [Bacteroides thetaiotaomicron VPI-5482],4PCT_C Crystal structure of a bacterial fucosidase with iminocyclitol (2S,3S,4R,5S)-3,4-dihydroxy-2-ethynyl-5-methylpyrrolidine [Bacteroides thetaiotaomicron VPI-5482],4PCT_D Crystal structure of a bacterial fucosidase with iminocyclitol (2S,3S,4R,5S)-3,4-dihydroxy-2-ethynyl-5-methylpyrrolidine [Bacteroides thetaiotaomicron VPI-5482]
2WVS_A 9.29e-49 38 447 17 440
Crystalstructure of an alpha-L-fucosidase GH29 trapped covalent intermediate from Bacteroides thetaiotaomicron in complex with 2- fluoro-fucosyl fluoride using an E288Q mutant [Bacteroides thetaiotaomicron VPI-5482],2WVS_B Crystal structure of an alpha-L-fucosidase GH29 trapped covalent intermediate from Bacteroides thetaiotaomicron in complex with 2- fluoro-fucosyl fluoride using an E288Q mutant [Bacteroides thetaiotaomicron VPI-5482],2WVS_C Crystal structure of an alpha-L-fucosidase GH29 trapped covalent intermediate from Bacteroides thetaiotaomicron in complex with 2- fluoro-fucosyl fluoride using an E288Q mutant [Bacteroides thetaiotaomicron VPI-5482],2WVS_D Crystal structure of an alpha-L-fucosidase GH29 trapped covalent intermediate from Bacteroides thetaiotaomicron in complex with 2- fluoro-fucosyl fluoride using an E288Q mutant [Bacteroides thetaiotaomicron VPI-5482]
2WVT_A 9.29e-49 38 447 17 440
Crystalstructure of an alpha-L-fucosidase GH29 from Bacteroides thetaiotaomicron in complex with a novel iminosugar fucosidase inhibitor [Bacteroides thetaiotaomicron VPI-5482],2WVT_B Crystal structure of an alpha-L-fucosidase GH29 from Bacteroides thetaiotaomicron in complex with a novel iminosugar fucosidase inhibitor [Bacteroides thetaiotaomicron VPI-5482],2WVU_A Crystal structure of a Michaelis complex of alpha-L-fucosidase GH29 from Bacteroides thetaiotaomicron with the synthetic substrate 4- nitrophenyl-alpha-L-fucose [Bacteroides thetaiotaomicron VPI-5482],2WVU_B Crystal structure of a Michaelis complex of alpha-L-fucosidase GH29 from Bacteroides thetaiotaomicron with the synthetic substrate 4- nitrophenyl-alpha-L-fucose [Bacteroides thetaiotaomicron VPI-5482],2WVU_C Crystal structure of a Michaelis complex of alpha-L-fucosidase GH29 from Bacteroides thetaiotaomicron with the synthetic substrate 4- nitrophenyl-alpha-L-fucose [Bacteroides thetaiotaomicron VPI-5482],2WVU_D Crystal structure of a Michaelis complex of alpha-L-fucosidase GH29 from Bacteroides thetaiotaomicron with the synthetic substrate 4- nitrophenyl-alpha-L-fucose [Bacteroides thetaiotaomicron VPI-5482]
4WSJ_A 9.68e-49 38 447 13 436
Crystalstructure of a bacterial fucodiase in complex with 1-((1R,2R,3R,4R,5R,6R)-2,3,4-trihydroxy-5-methyl-7-azabicyclo[4.1.0]heptan-7-yl)ethan-1-one [Bacteroides thetaiotaomicron VPI-5482],4WSJ_B Crystal structure of a bacterial fucodiase in complex with 1-((1R,2R,3R,4R,5R,6R)-2,3,4-trihydroxy-5-methyl-7-azabicyclo[4.1.0]heptan-7-yl)ethan-1-one [Bacteroides thetaiotaomicron VPI-5482],4WSJ_C Crystal structure of a bacterial fucodiase in complex with 1-((1R,2R,3R,4R,5R,6R)-2,3,4-trihydroxy-5-methyl-7-azabicyclo[4.1.0]heptan-7-yl)ethan-1-one [Bacteroides thetaiotaomicron VPI-5482],4WSJ_D Crystal structure of a bacterial fucodiase in complex with 1-((1R,2R,3R,4R,5R,6R)-2,3,4-trihydroxy-5-methyl-7-azabicyclo[4.1.0]heptan-7-yl)ethan-1-one [Bacteroides thetaiotaomicron VPI-5482]

Swiss-Prot Hits      download full data without filtering help

Created with Snap2244678911113415617820122324526829031233535737940242431433sp|P10901|FUCO_DICDI30428sp|Q6AYS4|FUCO2_RAT31428sp|Q99KR8|FUCO2_MOUSE30364sp|Q9BTY2|FUCO2_HUMAN30364sp|Q5RFI5|FUCO2_PONAB
Hit ID E-Value Query Start Query End Hit Start Hit End Description
P10901 2.66e-34 31 433 18 431
Alpha-L-fucosidase OS=Dictyostelium discoideum OX=44689 GN=alfA PE=3 SV=1
Q6AYS4 2.40e-33 30 428 22 424
Plasma alpha-L-fucosidase OS=Rattus norvegicus OX=10116 GN=Fuca2 PE=2 SV=1
Q99KR8 2.46e-33 31 428 25 426
Plasma alpha-L-fucosidase OS=Mus musculus OX=10090 GN=Fuca2 PE=1 SV=1
Q9BTY2 8.64e-32 30 364 30 370
Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA2 PE=1 SV=2
Q5RFI5 2.17e-31 30 364 28 368
Plasma alpha-L-fucosidase OS=Pongo abelii OX=9601 GN=FUCA2 PE=2 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000333 0.998835 0.000272 0.000204 0.000177 0.000160

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003565_00964.