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CAZyme Information: MGYG000003566_01525
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | F082 sp900769945 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; F082; F082; F082 sp900769945 | |||||||||||
| CAZyme ID | MGYG000003566_01525 | |||||||||||
| CAZy Family | GH23 | |||||||||||
| CAZyme Description | Membrane-bound lytic murein transglycosylase C | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 6596; End: 7777 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH23 | 236 | 388 | 4.3e-22 | 0.8074074074074075 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd16893 | LT_MltC_MltE | 4.94e-73 | 226 | 386 | 3 | 162 | membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins. MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda |
| PRK11671 | mltC | 4.64e-51 | 50 | 381 | 23 | 349 | membrane-bound lytic murein transglycosylase MltC. |
| cd16896 | LT_Slt70-like | 7.76e-36 | 222 | 390 | 4 | 146 | uncharacterized lytic transglycosylase subfamily with similarity to Slt70. Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. |
| cd13401 | Slt70-like | 1.49e-32 | 222 | 383 | 6 | 144 | 70kDa soluble lytic transglycosylase (Slt70) and similar proteins. Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda. |
| pfam01464 | SLT | 3.08e-27 | 228 | 344 | 3 | 106 | Transglycosylase SLT domain. This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| BCG64024.1 | 3.15e-52 | 44 | 388 | 42 | 399 |
| QQD25248.1 | 1.54e-51 | 18 | 389 | 23 | 368 |
| BBN58488.1 | 5.69e-51 | 68 | 382 | 83 | 386 |
| QQD22621.1 | 8.38e-51 | 18 | 389 | 23 | 368 |
| ALS34875.1 | 2.91e-49 | 13 | 393 | 16 | 403 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4C5F_A | 5.80e-34 | 67 | 390 | 26 | 340 | Structureof Lytic Transglycosylase MltC from Escherichia coli at 2.3 A resolution. [Escherichia coli],4C5F_B Structure of Lytic Transglycosylase MltC from Escherichia coli at 2.3 A resolution. [Escherichia coli] |
| 4CFO_A | 1.55e-33 | 67 | 390 | 26 | 340 | Structureof Lytic Transglycosylase MltC from Escherichia coli in complex with tetrasaccharide at 2.9 A resolution. [Escherichia coli],4CFO_B Structure of Lytic Transglycosylase MltC from Escherichia coli in complex with tetrasaccharide at 2.9 A resolution. [Escherichia coli],4CFP_A Crystal structure of MltC in complex with tetrasaccharide at 2.15 A resolution [Escherichia coli],4CFP_B Crystal structure of MltC in complex with tetrasaccharide at 2.15 A resolution [Escherichia coli],4CHX_A Crystal structure of MltC in complex with disaccharide pentapeptide DHl89 [Escherichia coli],4CHX_B Crystal structure of MltC in complex with disaccharide pentapeptide DHl89 [Escherichia coli] |
| 6GI4_B | 8.28e-17 | 218 | 368 | 18 | 165 | Structureof Lytic Transglycosylase MltE mutant S75A from E.coli [Escherichia coli] |
| 2Y8P_A | 1.55e-16 | 218 | 368 | 18 | 165 | CrystalStructure of an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase (MltE) from Escherichia coli [Escherichia coli K-12],2Y8P_B Crystal Structure of an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase (MltE) from Escherichia coli [Escherichia coli K-12] |
| 6GHZ_A | 1.55e-16 | 218 | 368 | 18 | 165 | Structureof Lytic Transglycosylase MltE mutant Y192F from E.coli [Escherichia coli K-12],6GHZ_B Structure of Lytic Transglycosylase MltE mutant Y192F from E.coli [Escherichia coli K-12] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q4QMD8 | 7.31e-43 | 75 | 389 | 52 | 354 | Membrane-bound lytic murein transglycosylase C OS=Haemophilus influenzae (strain 86-028NP) OX=281310 GN=mltC PE=3 SV=1 |
| A5UHR5 | 7.31e-43 | 75 | 389 | 52 | 354 | Membrane-bound lytic murein transglycosylase C OS=Haemophilus influenzae (strain PittGG) OX=374931 GN=mltC PE=3 SV=1 |
| P44049 | 7.31e-43 | 75 | 389 | 52 | 354 | Membrane-bound lytic murein transglycosylase C OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) OX=71421 GN=mltC PE=3 SV=1 |
| A5UDW4 | 5.43e-42 | 75 | 389 | 52 | 354 | Membrane-bound lytic murein transglycosylase C OS=Haemophilus influenzae (strain PittEE) OX=374930 GN=mltC PE=3 SV=1 |
| Q65VT8 | 1.52e-40 | 67 | 390 | 44 | 355 | Membrane-bound lytic murein transglycosylase C OS=Mannheimia succiniciproducens (strain MBEL55E) OX=221988 GN=mltC PE=3 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.001203 | 0.804990 | 0.192922 | 0.000309 | 0.000292 | 0.000268 |