CAZyme Information: MGYG000003642_00794

Basic Information

• Species: RUG572 sp900771305
• Lineage: Bacteria; Verrucomicrobiota; Kiritimatiellae; RFP12; UBA1067; RUG572; RUG572 sp900771305
• CAZyme ID: MGYG000003642_00794
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
750	MGYG000003642_145|CGC1	81375.16	8.6185

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003642	3810265	MAG	Fiji	Oceania

• Gene Location: Start: 14060; End: 16312 Strand: -

Full Sequence      

MSPRFKFAAKRVSFVGACVLALSALVVLVSWALIDPRLDAAERYPGGTVLRDNAGRVLRV
SLGADDVDCRPYYVASTNDWVVKALIASEDRRFFEHWGVDLPSVLRACIQNVTSMRRISG
ASTITMQASRLISPHPRTLAWKYVEAFRALKTECVHDKLWIISQYLNRAPFGSNLVGVEA
AANGWFGKKTRDLGIGEAALLAGMVQSPSRFRPDRNLGRALKRREYVLARMRDLGMIDPG
QYEGARSSQPRILRGPRPFEEPFFCDWAMRRVERLGTPGGDFRTTLDADVQAHAKRAVAN
ASAKGLSAAAVVLRVASGEVVAMACSGDYFSSEAGQVNVAIAPRPAGSTLKTFLTAVAMD
RGLVTPDELLSDVPRAYQGYNPQNFDTTHRGLVTVADALVLSLNLPFVQMLQRVGVSNFG
TMLRSLGCRNMDAPDESFGLGMAIGNVHVSLLEVVGAYGCIARGGVMREPCALVKEVEQQ
KMMEGVRLLSEGSCWLISDILSGDERSAAALGHVADVKTSRFAWKTGTSAAFRDAWTVAW
NPEYVVGVWCGHKSGGFGDSSVVGMLAAAPYAWELARSLYPADDGPWYGAPPEEVVTRSV
CIESGLPANPDCPATKKGRALRGRSSSALCPIHQRGLDGELVTKSDALIAAFRGIEHKAR
QLAIRKPENGAVFRLLRDVPGQKIVFRVVGNVEGGRLWWFVDGRNAGETRGPQPFVWNPD
LGPHRISCSSEDGITASVDITVTEGEAPEL

Enzyme Prediction     

No EC number prediction in MGYG000003642_00794.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	76	232	2.9e-48	0.8870056497175142

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02073	PBP_1c	2.12e-156	45	742	9	726	penicillin-binding protein 1C. This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG4953	PbpC	6.38e-153	17	742	8	731	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
COG0744	MrcB	1.16e-119	12	619	21	661	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	2.17e-115	81	551	14	500	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
PRK11240	PRK11240	9.58e-93	68	743	69	772	penicillin-binding protein 1C; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AXA36662.1	3.01e-115	31	742	62	856
QTX32363.1	3.68e-105	16	743	4	712
QVL36238.1	7.63e-104	22	742	10	711
ADE56317.1	8.27e-104	29	749	27	726
ACL69723.1	1.33e-103	1	742	1	768

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2OQO_A	1.29e-32	81	245	32	197	Crystalstructure of a peptidoglycan glycosyltransferase from a class A PBP: insight into bacterial cell wall synthesis [Aquifex aeolicus VF5],3D3H_A Crystal structure of a complex of the peptidoglycan glycosyltransferase domain from Aquifex aeolicus and neryl moenomycin A [Aquifex aeolicus],3NB7_A Crystal structure of Aquifex Aeolicus Peptidoglycan Glycosyltransferase in complex with Decarboxylated Neryl Moenomycin [Aquifex aeolicus]
3NB6_A	4.47e-32	81	245	32	197	Crystalstructure of Aquifex aeolicus peptidoglycan glycosyltransferase in complex with Methylphosphoryl Neryl Moenomycin [Aquifex aeolicus]
3UDF_A	4.46e-29	82	470	52	544	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
4OON_A	1.15e-27	82	551	52	694	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
5FGZ_A	1.37e-27	79	600	166	711	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P76577	1.08e-68	64	639	59	627	Penicillin-binding protein 1C OS=Escherichia coli (strain K12) OX=83333 GN=pbpC PE=1 SV=1
P38050	1.08e-45	81	552	79	570	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
O66874	5.89e-40	33	598	30	686	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
P70997	6.45e-39	14	630	21	657	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
P39793	5.06e-35	36	617	64	680	Penicillin-binding protein 1A/1B OS=Bacillus subtilis (strain 168) OX=224308 GN=ponA PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000041	0.000004	0.000000	0.000000	0.000000	0.000001

TMHMM  Annotations     

start	end
12	34