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CAZyme Information: MGYG000003649_01270

You are here: Home > Sequence: MGYG000003649_01270

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species UBA1711 sp900771365
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; P3; UBA1711; UBA1711 sp900771365
CAZyme ID MGYG000003649_01270
CAZy Family GH2
CAZyme Description Beta-galactosidase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
952 107577.69 6.0577
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003649 3060385 MAG Fiji Oceania
Gene Location Start: 3155;  End: 6013  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000003649_01270.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH2 58 627 2e-113 0.6462765957446809

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd09019 galactose_mutarotase_like 2.40e-168 619 948 2 326
galactose mutarotase_like. Galactose mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose. Beta-D-galactose is produced by the degradation of lactose, a disaccharide composed of beta-D-glucose and beta-D-galactose. This epimerization reaction is the first step in the four-step Leloir pathway, which converts galactose into metabolically important glucose. This epimerization step is followed by the phosophorylation of alpha-D-galactose by galactokinase, an enzyme which can only act on the alpha anomer. A glutamate and a histidine residue of the galactose mutarotase have been shown to be critical for catalysis, the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. Galactose mutarotase is a member of the aldose-1-epimerase superfamily.
TIGR02636 galM_Leloir 1.52e-121 614 948 2 335
galactose mutarotase. Members of this protein family act as galactose mutarotase (D-galactose 1-epimerase) and participate in the Leloir pathway for galactose/glucose interconversion. All members of the seed alignment for this model are found in gene clusters with other enzymes of the Leloir pathway. This enzyme family belongs to the aldose 1-epimerase family, described by pfam01263. However, the enzyme described as aldose 1-epimerase itself (EC 5.1.3.3) is called broadly specific for D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose. The restricted genome context for genes in this family suggests members should act primarily on D-galactose.
PRK11055 galM 2.93e-112 617 948 10 339
galactose-1-epimerase; Provisional
PLN00194 PLN00194 3.29e-100 613 950 6 337
aldose 1-epimerase; Provisional
pfam01263 Aldose_epim 4.68e-89 617 947 1 300
Aldose 1-epimerase.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
BAR50306.1 2.12e-285 34 611 25 602
AEW20877.1 6.02e-285 34 611 25 602
BAR53131.1 6.02e-285 34 611 25 602
QUR50130.1 1.22e-274 34 611 25 603
ABR42251.1 9.88e-274 34 611 25 603

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
7SF2_A 1.25e-234 34 606 9 582
ChainA, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_B Chain B, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_C Chain C, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_D Chain D, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_E Chain E, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_F Chain F, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838]
1SNZ_A 1.49e-75 627 951 31 344
Crystalstructure of apo human galactose mutarotase [Homo sapiens],1SNZ_B Crystal structure of apo human galactose mutarotase [Homo sapiens],1SO0_A Crystal structure of human galactose mutarotase complexed with galactose [Homo sapiens],1SO0_B Crystal structure of human galactose mutarotase complexed with galactose [Homo sapiens],1SO0_C Crystal structure of human galactose mutarotase complexed with galactose [Homo sapiens],1SO0_D Crystal structure of human galactose mutarotase complexed with galactose [Homo sapiens]
4RNL_A 7.05e-73 626 949 33 341
Thecrystal structure of a possible galactose mutarotase from Streptomyces platensis subsp. rosaceus [Streptomyces platensis],4RNL_B The crystal structure of a possible galactose mutarotase from Streptomyces platensis subsp. rosaceus [Streptomyces platensis],4RNL_C The crystal structure of a possible galactose mutarotase from Streptomyces platensis subsp. rosaceus [Streptomyces platensis],4RNL_D The crystal structure of a possible galactose mutarotase from Streptomyces platensis subsp. rosaceus [Streptomyces platensis]
1LUR_A 5.02e-52 621 949 17 336
CrystalStructure of the GalM/aldose Epimerase Homologue from C. elegans, Northeast Structural Genomics Target WR66 [Caenorhabditis elegans],1LUR_B Crystal Structure of the GalM/aldose Epimerase Homologue from C. elegans, Northeast Structural Genomics Target WR66 [Caenorhabditis elegans]
1L7J_A 9.53e-44 617 950 13 338
ChainA, galactose mutarotase [Lactococcus lactis],1L7J_B Chain B, galactose mutarotase [Lactococcus lactis],1L7K_A Chain A, galactose mutarotase [Lactococcus lactis],1L7K_B Chain B, galactose mutarotase [Lactococcus lactis],1MMU_A Chain A, Aldose 1-epimerase [Lactococcus lactis],1MMU_B Chain B, Aldose 1-epimerase [Lactococcus lactis],1MMX_A Chain A, Aldose 1-epimerase [Lactococcus lactis],1MMX_B Chain B, Aldose 1-epimerase [Lactococcus lactis],1MMY_A Chain A, Aldose 1-epimerase [Lactococcus lactis],1MMY_B Chain B, Aldose 1-epimerase [Lactococcus lactis],1MMZ_A Chain A, Aldose 1-epimerase [Lactococcus lactis],1MMZ_B Chain B, Aldose 1-epimerase [Lactococcus lactis],1MN0_A Chain A, Aldose 1-epimerase [Lactococcus lactis],1MN0_B Chain B, Aldose 1-epimerase [Lactococcus lactis]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P05149 2.66e-81 612 948 33 377
Aldose 1-epimerase OS=Acinetobacter calcoaceticus OX=471 GN=mro PE=1 SV=1
Q66HG4 2.15e-79 616 951 19 342
Galactose mutarotase OS=Rattus norvegicus OX=10116 GN=Galm PE=1 SV=1
Q8K157 1.11e-78 616 951 19 342
Galactose mutarotase OS=Mus musculus OX=10090 GN=Galm PE=1 SV=1
Q9GKX6 2.96e-77 627 951 29 342
Galactose mutarotase OS=Sus scrofa OX=9823 GN=GALM PE=2 SV=1
Q5EA79 1.08e-75 627 951 29 342
Galactose mutarotase OS=Bos taurus OX=9913 GN=GALM PE=2 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000344 0.999031 0.000164 0.000170 0.000149 0.000137

TMHMM  Annotations      download full data without filtering help

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