dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000003655_01887

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Basic Information help

Species

Mitsuokella sp900552565

Lineage

Bacteria; Firmicutes_C; Negativicutes; Selenomonadales; Selenomonadaceae; Mitsuokella; Mitsuokella sp900552565

CAZyme ID

MGYG000003655_01887

CAZy Family

GT30

CAZyme Description

Tetraacyldisaccharide 4'-kinase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
829	MGYG000003655_83\|CGC2	93315.9	7.5962

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003655	2162021	MAG	United States	North America

Gene Location

Start: 56760; End: 59249 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000003655_01887.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GT30	33	215	2.7e-58	0.9830508474576272

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK05749	PRK05749	1.46e-133	22	415	23	409	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed
COG1519	KdtA	9.00e-121	22	422	22	415	3-deoxy-D-manno-octulosonic-acid transferase [Cell wall/membrane/envelope biogenesis].
pfam02606	LpxK	4.93e-99	473	823	4	318	Tetraacyldisaccharide-1-P 4'-kinase. This family consists of tetraacyldisaccharide-1-P 4'-kinase also known as Lipid-A 4'-kinase or Lipid A biosynthesis protein LpxK, EC:2.7.1.130. This enzyme catalyzes the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D -glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glu cosam inyl beta-phosphate <=> ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D- glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate. This enzyme is involved in the synthesis of lipid A portion of the bacterial lipopolysaccharide layer (LPS). The family contains a P-loop motif at the N-terminus.
PRK00652	lpxK	2.50e-79	474	824	19	325	tetraacyldisaccharide 4'-kinase; Reviewed
COG1663	LpxK	9.78e-75	473	807	19	318	Tetraacyldisaccharide-1-P 4'-kinase [Cell wall/membrane/envelope biogenesis].

CAZyme Hits help

Hit ID	Query Start	Query End	Hit Start	Hit End
BAL84301.1	1	829	1	829
AEC00854.1	1	826	1	825
QNH55247.1	1	828	1	835
AKT54066.1	1	827	1	834
ANR70603.1	1	828	1	835

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4EHX_A	3.78e-39	477	756	9	265	Crystalstructure of LpxK from Aquifex aeolicus at 1.9 angstrom resolution [Aquifex aeolicus VF5],4EHY_A Crystal structure of LpxK from Aquifex aeolicus in complex with ADP/Mg2+ at 2.2 angstrom resolution [Aquifex aeolicus VF5],4ITL_A Crystal structure of LpxK from Aquifex aeolicus in complex with AMP-PCP at 2.1 angstrom resolution [Aquifex aeolicus VF5],4ITM_A Crystal structure of 'apo' form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution [Aquifex aeolicus VF5],4ITN_A Crystal structure of 'compact P-loop' LpxK from Aquifex aeolicus in complex with chloride at 2.2 angstrom resolution [Aquifex aeolicus VF5],4LKV_A Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK [Aquifex aeolicus VF5],4LKV_B Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK [Aquifex aeolicus VF5],4LKV_C Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK [Aquifex aeolicus VF5],4LKV_D Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK [Aquifex aeolicus VF5]
4EHW_A	3.97e-39	477	756	11	267	Crystalstructure of LpxK from Aquifex aeolicus at 2.3 angstrom resolution [Aquifex aeolicus VF5]
2XCI_A	3.42e-31	40	392	30	344	Membrane-embeddedmonofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form [Aquifex aeolicus],2XCI_B Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form [Aquifex aeolicus],2XCI_C Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form [Aquifex aeolicus],2XCI_D Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form [Aquifex aeolicus],2XCU_A Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, complex with CMP [Aquifex aeolicus],2XCU_B Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, complex with CMP [Aquifex aeolicus],2XCU_C Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, complex with CMP [Aquifex aeolicus],2XCU_D Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, complex with CMP [Aquifex aeolicus]
4BFC_A	1.12e-15	229	427	33	231	ChainA, 3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE [Acinetobacter baumannii]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q2LVL1	7.11e-72	473	819	26	369	Tetraacyldisaccharide 4'-kinase OS=Syntrophus aciditrophicus (strain SB) OX=56780 GN=lpxK PE=3 SV=1
B8CZC3	2.55e-70	450	820	10	383	Tetraacyldisaccharide 4'-kinase OS=Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) OX=373903 GN=lpxK PE=3 SV=1
P0AC76	3.85e-65	22	437	23	425	3-deoxy-D-manno-octulosonic acid transferase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) OX=199310 GN=waaA PE=3 SV=1
P0AC77	3.85e-65	22	437	23	425	3-deoxy-D-manno-octulosonic acid transferase OS=Escherichia coli O157:H7 OX=83334 GN=waaA PE=3 SV=1
P0AC75	3.85e-65	22	437	23	425	3-deoxy-D-manno-octulosonic acid transferase OS=Escherichia coli (strain K12) OX=83333 GN=waaA PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000004	0.000040	0.000001	0.000000	0.000000	0.000001

TMHMM Annotations download full data without filtering help

start	end
3	25