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CAZyme Information: MGYG000003661_01261

You are here: Home > Sequence: MGYG000003661_01261

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Acetatifactor sp900554205
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Acetatifactor; Acetatifactor sp900554205
CAZyme ID MGYG000003661_01261
CAZy Family GT0
CAZyme Description UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronate 2-epimerase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
386 MGYG000003661_92|CGC1 43341.61 5.937
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003661 3177635 MAG Peru South America
Gene Location Start: 4277;  End: 5437  Strand: -

Full Sequence      Download help

MASFKNNGKL  KLLIIVGTRP  EIIRLAAVIK  KCRTYFDTIL  AHTGQNYDYN  LNGVFFHDLE60
LEDPEVYLNA  VGKDLGETMG  NIIAKSYELM  VEIQPDAVLV  LGDTNSCLSV  IGAKRLHIPI120
FHMEAGNRCK  DECLPEETNR  RIVDIISDVN  MAYSEHARRY  LADCGLPKER  TYVTGSPMAE180
VLHNNLARIE  ASDIHARLGL  EKGKYILLSA  HREENIDTDK  NFNSLFNAIN  KMAEKYDMPI240
LYSCHPRSKK  RLEASGFQLD  ARVVQHEPLG  FHDYNCLQMN  AFAVVSDSGT  LPEESSFFTS300
VGHPFPAICI  RTSTERPEAI  DKACFIIAGI  DENSLLQAVD  TAVEMNRAGD  YGIPVPDYVE360
ENVSTKVVKI  IQSYTGIVNK  MVWRKF386

Enzyme Prediction      help

No EC number prediction in MGYG000003661_01261.

CDD Domains      download full data without filtering help

Created with Snap19385777961151351541731932122312502702893083283473667385WecB11372GTB_UDP-GlcNAc_2-Epimerase33371Epimerase_2
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG0381 WecB 1.95e-139 7 385 1 382
UDP-N-acetylglucosamine 2-epimerase [Cell wall/membrane/envelope biogenesis].
cd03786 GTB_UDP-GlcNAc_2-Epimerase 1.05e-135 11 372 1 365
UDP-N-acetylglucosamine 2-epimerase and similar proteins. Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family (EC 5.1.3.14) are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues (UDP-ManNAc) for use in the biosynthesis of a variety of cell surface polysaccharides; The mammalian enzyme is bifunctional, catalyzing both the inversion of stereochemistry at C-2 and the hydrolysis of the UDP-sugar linkage to generate free ManNAc. It also catalyzes the phosphorylation of ManNAc to generate ManNAc 6-phosphate, a precursor to salic acids. In mammals, sialic acids are found at the termini of oligosaccharides in a large variety of cell surface glycoconjugates and are key mediators of cell-cell recognition events. Mutations in human members of this family have been associated with Sialuria, a rare disease caused by the disorders of sialic acid metabolism. This family belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
pfam02350 Epimerase_2 9.80e-91 33 371 5 335
UDP-N-acetylglucosamine 2-epimerase. This family consists of UDP-N-acetylglucosamine 2-epimerases EC:5.1.3.14 this enzyme catalyzes the production of UDP-ManNAc from UDP-GlcNAc. Note that some of the enzymes is this family are bifunctional, in these instances Pfam matches only the N-terminal half of the protein suggesting that the additional C-terminal part (when compared to mono-functional members of this family) is responsible for the UPD-N-acetylmannosamine kinase activity of these enzymes. This hypothesis is further supported by the assumption that the C-terminal part of rat Gne is the kinase domain.

CAZyme Hits      help

Created with Snap19385777961151351541731932122312502702893083283473664385AOP03843.1|GT04385AOP02687.1|GT04385AOP03732.1|GT04385AOP02662.1|GT04385AOP03614.1|GT0
Hit ID E-Value Query Start Query End Hit Start Hit End
AOP03843.1 9.59e-193 4 385 15 402
AOP02687.1 9.59e-193 4 385 15 402
AOP03732.1 9.59e-193 4 385 15 402
AOP02662.1 9.59e-193 4 385 15 402
AOP03614.1 9.59e-193 4 385 15 402

PDB Hits      download full data without filtering help

Created with Snap193857779611513515417319321223125027028930832834736613864HWG_A113474NEQ_A113475ENZ_A93503BEO_A93374FKZ_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
4HWG_A 9.15e-106 1 386 1 385
Structureof UDP-N-acetylglucosamine 2-epimerase from Rickettsia bellii [Rickettsia bellii RML369-C]
4NEQ_A 6.95e-54 11 347 2 342
Thestructure of UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii [Methanocaldococcus jannaschii DSM 2661],4NES_A Crystal structure of Methanocaldococcus jannaschii UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP [Methanocaldococcus jannaschii DSM 2661]
5ENZ_A 5.62e-32 11 347 3 336
S.aureus MnaA-UDP co-structure [Staphylococcus aureus],5ENZ_B S. aureus MnaA-UDP co-structure [Staphylococcus aureus]
3BEO_A 4.39e-30 9 350 8 347
AStructural Basis for the allosteric regulation of non-hydrolyzing UDP-GlcNAc 2-epimerases [Bacillus anthracis],3BEO_B A Structural Basis for the allosteric regulation of non-hydrolyzing UDP-GlcNAc 2-epimerases [Bacillus anthracis]
4FKZ_A 1.02e-29 9 337 3 328
Crystalstructure of Bacillus subtilis UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP [Bacillus subtilis subsp. subtilis str. 168],4FKZ_B Crystal structure of Bacillus subtilis UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP [Bacillus subtilis subsp. subtilis str. 168]

Swiss-Prot Hits      download full data without filtering help

Created with Snap193857779611513515417319321223125027028930832834736611347sp|Q6LZC4|WECB_METMP10347sp|Q58899|WECB_METJA10373sp|Q6M0B4|WECBH_METMP10343sp|G3XD61|WBPI_PSEAE10377sp|Q9X0C4|Y1034_THEMA
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q6LZC4 2.69e-55 11 347 3 341
UDP-N-acetylglucosamine 2-epimerase OS=Methanococcus maripaludis (strain S2 / LL) OX=267377 GN=wecB PE=1 SV=1
Q58899 1.47e-54 10 347 1 342
UDP-N-acetylglucosamine 2-epimerase OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) OX=243232 GN=wecB PE=1 SV=1
Q6M0B4 7.37e-52 10 373 1 356
UDP-N-acetylglucosamine 2-epimerase homolog OS=Methanococcus maripaludis (strain S2 / LL) OX=267377 GN=MMP0357 PE=1 SV=1
G3XD61 1.74e-39 10 343 1 327
UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronate 2-epimerase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=wbpI PE=1 SV=1
Q9X0C4 1.98e-31 10 377 2 370
Putative UDP-N-acetylglucosamine 2-epimerase OS=Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) OX=243274 GN=TM_1034 PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000047 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003661_01261.