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CAZyme Information: MGYG000003687_00489
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Paenibacillus polymyxa | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes; Bacilli; Paenibacillales; Paenibacillaceae; Paenibacillus; Paenibacillus polymyxa | |||||||||||
| CAZyme ID | MGYG000003687_00489 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Linear gramicidin synthase subunit A | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 9350; End: 12079 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd17655 | A_NRPS_Bac | 0.0 | 126 | 624 | 1 | 490 | bacitracin synthetase and related proteins. This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. |
| PRK12316 | PRK12316 | 0.0 | 71 | 871 | 460 | 1248 | peptide synthase; Provisional |
| PRK12467 | PRK12467 | 0.0 | 72 | 887 | 463 | 1284 | peptide synthase; Provisional |
| PRK12316 | PRK12316 | 0.0 | 57 | 888 | 2992 | 3804 | peptide synthase; Provisional |
| PRK12467 | PRK12467 | 0.0 | 66 | 875 | 1518 | 2334 | peptide synthase; Provisional |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QND46664.1 | 4.52e-135 | 78 | 876 | 965 | 1774 |
| BAZ00088.1 | 8.60e-125 | 61 | 705 | 518 | 1178 |
| BAZ75991.1 | 8.60e-125 | 61 | 705 | 518 | 1178 |
| AFZ04852.1 | 2.40e-124 | 13 | 884 | 478 | 1330 |
| BAY30132.1 | 2.25e-121 | 9 | 705 | 2595 | 3294 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6MFZ_A | 8.22e-160 | 41 | 713 | 1142 | 1805 | Crystalstructure of dimodular LgrA in a condensation state [Brevibacillus parabrevis],6MFZ_B Crystal structure of dimodular LgrA in a condensation state [Brevibacillus parabrevis] |
| 1AMU_A | 8.05e-137 | 103 | 660 | 20 | 563 | PhenylalanineActivating Domain Of Gramicidin Synthetase 1 In A Complex With Amp And Phenylalanine [Brevibacillus brevis],1AMU_B Phenylalanine Activating Domain Of Gramicidin Synthetase 1 In A Complex With Amp And Phenylalanine [Brevibacillus brevis] |
| 6P1J_A | 1.15e-134 | 55 | 620 | 399 | 964 | Thestructure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module [Eleftheria terrae],6P1J_B The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module [Eleftheria terrae] |
| 2VSQ_A | 2.24e-133 | 2 | 705 | 345 | 1039 | Structureof surfactin A synthetase C (SrfA-C), a nonribosomal peptide synthetase termination module [Bacillus subtilis] |
| 6MFY_A | 1.28e-132 | 41 | 624 | 1142 | 1716 | Crystalstructure of a 5-domain construct of LgrA in the substrate donation state [Brevibacillus parabrevis],6MG0_A Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis],6MG0_B Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q9R9I9 | 3.23e-244 | 50 | 875 | 190 | 1013 | Mycosubtilin synthase subunit C OS=Bacillus subtilis OX=1423 GN=mycC PE=3 SV=1 |
| P09095 | 1.81e-208 | 124 | 875 | 29 | 769 | Tyrocidine synthase 1 OS=Brevibacillus parabrevis OX=54914 GN=tycA PE=1 SV=2 |
| Q70LM7 | 4.79e-208 | 41 | 875 | 1139 | 1965 | Linear gramicidin synthase subunit A OS=Brevibacillus parabrevis OX=54914 GN=lgrA PE=1 SV=1 |
| P0C061 | 4.13e-206 | 103 | 870 | 20 | 774 | Gramicidin S synthase 1 OS=Aneurinibacillus migulanus OX=47500 GN=grsA PE=1 SV=1 |
| P0C062 | 1.80e-204 | 103 | 870 | 20 | 774 | Gramicidin S synthase 1 OS=Brevibacillus brevis OX=1393 GN=grsA PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000039 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |