You are browsing environment: HUMAN GUT
CAZyme Information: MGYG000003687_00980
You are here: Home > Sequence: MGYG000003687_00980
Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Paenibacillus polymyxa | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes; Bacilli; Paenibacillales; Paenibacillaceae; Paenibacillus; Paenibacillus polymyxa | |||||||||||
| CAZyme ID | MGYG000003687_00980 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | D-alanine--poly(phosphoribitol) ligase subunit 1 | |||||||||||
| CAZyme Property |
|
|||||||||||
| Genome Property |
|
|||||||||||
| Gene Location | Start: 65656; End: 70845 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd05930 | A_NRPS | 0.0 | 119 | 599 | 1 | 444 | The adenylation domain of nonribosomal peptide synthetases (NRPS). The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. |
| cd12116 | A_NRPS_Ta1_like | 0.0 | 119 | 599 | 1 | 470 | The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity. |
| COG3321 | PksD | 0.0 | 728 | 1321 | 3 | 582 | Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]. |
| cd17655 | A_NRPS_Bac | 1.90e-175 | 109 | 599 | 1 | 486 | bacitracin synthetase and related proteins. This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. |
| PRK12316 | PRK12316 | 4.77e-173 | 45 | 683 | 4490 | 5136 | peptide synthase; Provisional |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| BAY90071.1 | 1.97e-270 | 24 | 1243 | 496 | 1722 |
| BAY30132.1 | 3.05e-270 | 25 | 1243 | 498 | 1725 |
| BAZ00088.1 | 5.66e-270 | 25 | 1243 | 498 | 1723 |
| BAZ75991.1 | 5.66e-270 | 25 | 1243 | 498 | 1723 |
| AFY93865.1 | 1.51e-241 | 101 | 1234 | 326 | 1453 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 5ELP_A | 1.39e-254 | 722 | 1332 | 20 | 620 | Ketosynthasefrom module 1 of the bacillaene synthase from Bacillus amyloliquefaciens FZB42 [Bacillus amyloliquefaciens],5ELP_B Ketosynthase from module 1 of the bacillaene synthase from Bacillus amyloliquefaciens FZB42 [Bacillus amyloliquefaciens],5ELP_C Ketosynthase from module 1 of the bacillaene synthase from Bacillus amyloliquefaciens FZB42 [Bacillus amyloliquefaciens],5ELP_D Ketosynthase from module 1 of the bacillaene synthase from Bacillus amyloliquefaciens FZB42 [Bacillus amyloliquefaciens] |
| 6MHL_A | 6.27e-242 | 726 | 1330 | 22 | 613 | Crystalstructure of ketosynthase twelve from bacillaene polyketide synthase in Bacillus amyloliquefaciens [Bacillus amyloliquefaciens],6MHL_B Crystal structure of ketosynthase twelve from bacillaene polyketide synthase in Bacillus amyloliquefaciens [Bacillus amyloliquefaciens] |
| 5U89_A | 1.10e-153 | 84 | 694 | 3 | 610 | Crystalstructure of a cross-module fragment from the dimodular NRPS DhbF [Geobacillus sp. Y4.1MC1] |
| 5ENY_A | 7.87e-136 | 640 | 1329 | 67 | 764 | Ketosynthasefrom module 6 connected to acyl carrier protein from module 5 (unobservable) of the bacillaene synthase from Bacillus subtilis 168 [Bacillus subtilis subsp. subtilis str. 168],5ENY_B Ketosynthase from module 6 connected to acyl carrier protein from module 5 (unobservable) of the bacillaene synthase from Bacillus subtilis 168 [Bacillus subtilis subsp. subtilis str. 168],5ENY_C Ketosynthase from module 6 connected to acyl carrier protein from module 5 (unobservable) of the bacillaene synthase from Bacillus subtilis 168 [Bacillus subtilis subsp. subtilis str. 168],5ENY_D Ketosynthase from module 6 connected to acyl carrier protein from module 5 (unobservable) of the bacillaene synthase from Bacillus subtilis 168 [Bacillus subtilis subsp. subtilis str. 168],5ENY_E Ketosynthase from module 6 connected to acyl carrier protein from module 5 (unobservable) of the bacillaene synthase from Bacillus subtilis 168 [Bacillus subtilis subsp. subtilis str. 168],5ENY_F Ketosynthase from module 6 connected to acyl carrier protein from module 5 (unobservable) of the bacillaene synthase from Bacillus subtilis 168 [Bacillus subtilis subsp. subtilis str. 168],5ENY_G Ketosynthase from module 6 connected to acyl carrier protein from module 5 (unobservable) of the bacillaene synthase from Bacillus subtilis 168 [Bacillus subtilis subsp. subtilis str. 168],5ENY_H Ketosynthase from module 6 connected to acyl carrier protein from module 5 (unobservable) of the bacillaene synthase from Bacillus subtilis 168 [Bacillus subtilis subsp. subtilis str. 168] |
| 5ERF_A | 1.94e-130 | 728 | 1332 | 24 | 616 | Ketosynthasefrom module 6 of the bacillaene synthase from Bacillus subtilis 168 [Bacillus subtilis subsp. subtilis str. 168],5ERF_B Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168 [Bacillus subtilis subsp. subtilis str. 168] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P40806 | 0.0 | 2 | 1669 | 1051 | 2987 | Polyketide synthase PksJ OS=Bacillus subtilis (strain 168) OX=224308 GN=pksJ PE=1 SV=3 |
| O31782 | 0.0 | 1 | 1669 | 362 | 2316 | Polyketide synthase PksN OS=Bacillus subtilis (strain 168) OX=224308 GN=pksN PE=1 SV=3 |
| Q2T4N2 | 1.21e-303 | 21 | 1321 | 478 | 1825 | Polyketide synthase ThaH OS=Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264) OX=271848 GN=thaH PE=3 SV=1 |
| D4AU31 | 2.31e-191 | 81 | 1253 | 8 | 1145 | PKS-NRPS hybrid synthetase swnK OS=Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) OX=663331 GN=swnK PE=3 SV=1 |
| E9F8M3 | 6.59e-190 | 79 | 1247 | 8 | 1131 | PKS-NRPS hybrid synthetase swnK OS=Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) OX=655844 GN=swnK PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000062 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |