CAZyme Information: MGYG000003689_00117

Basic Information

• Species: Faecalicoccus sp900546545
• Lineage: Bacteria; Firmicutes; Bacilli; Erysipelotrichales; Erysipelotrichaceae; Faecalicoccus; Faecalicoccus sp900546545
• CAZyme ID: MGYG000003689_00117
• CAZy Family: GH23
• CAZyme Description: DNA mismatch repair protein MutS

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
3088		346863.7	4.5977

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003689	2478315	Isolate	China	Asia

• Gene Location: Start: 114828; End: 124094 Strand: +

Full Sequence      

MASKLQEYRRMSEEAQRQLTGSLERWQSFLATASRLYKYPYHEQVMIHAQRPDATACAEF
DVWNNTMRRYVRRGSKGIALIDTSGDRERLRYVFDVSDTGTRPNSRSLNLWELREEHIPA
VSSMLEKNYGVPAGESLAVQLEAVASQLAREYWEDNRRDILGILEDSFLEEYDEFNVGVA
FRNAAEVSISYSLMLRCGLEPENYFEHEDFMSVFDFNTPETAGALGTAVSGINQQVLREI
GATIRNYEREQIAERSMAYENDVQAERGLSDPGHQTERAGGYTHREVRADAETVPEGASP
DSVEPTGAVGAVVSAPSGDRRDGAPETGRADAADGEAGRRDGRTEAQGPAEMGGHDEYAE
GAGRGDHSERAGVQLTADELEPPEELNNGYPAGTEFEQLSLNLFLSEQEQISQIDEADRT
TEVLSAFSFAQTEIDDMLRFGSNTSHAREHIADAFQKQKPIEEIAALLQREFHGGYGIRG
EHGDYAAWYDGDGIHLHKGREARYAADSQVITWEAAAERIGQMLEEGSFASNVELAEAGG
RVRSELAQSLLYLKHDLSEEANRVGYFSSMDDLPAGYPDATAALAEKMEDNAFADTLRGE
FLAFLNDYAENRGLLRFHYHRMDELWQGIRDISAERRVYPDGPADLAEPQGFITEDEISE
ALAGGSSVAGGKGRIYAFFTADHTIKEKADFLKQEYGIGGRSHALSGADHSSEDHSAKGI
RLTKGGCAPVELNWTKVAERVDSLIRKDRYLTPKEQELYQQNLRRNSIYNTYNEVKHDHP
DDMVLFQVGDFFELYGEDARQASELLDIRLTTRNIPGVGHVEMCGVPSHALDGYVEQLRA
HFDVTISAASEDSKERSVYTLRAFAQEIDLSRYDVGYGAMGNGVTVWNRKETEHGDYKTI
AHIDPDRTVKFYDDSLPDAIKEQIQRFADTSEMTISATQDASVFSVPPAGKEPVLEAEPA
AVPKPVTADEISDALIRWNGSFESKSRVNDYMLAHGRERGAAVWLKDEFGGADIFSVVTN
HGTLELPWAKVQRQLGILVNDGRFFTEADRMLAQAEQIAAQSEVEPYERFAVIETDEGYG
IWDDLHDGLYVDEDGVTADFDSEWVAENYLLELKEKIAQREAAEWEYVERSKYEAQTEGN
DAVDVPPGIASPEKAEPAEMESESHFQDDNDLIGAELTLDGRRFAVDDVRDGRASLRDIT
FQDGTGFPIFRNEPVETVRGILFPEKTTVPQVNLEAELTEAELALMRPQLDAAGIDYLVA
NAGYNRRTISFSSQHYREVQDMLDALPEELEQPRFTVELTSDAFEEPFIIRDNSVPEGRD
GQYYDVGGIYQTFRSQQEAQKYADRLNGKEPFEQPQMTSETKAIYPGEQTGLPYDIVTER
LRAEPEHTPPEPEVSPDDAINANPVSVQIGGEWQTFPNAGAAEQAMYEEYRAQTHRNAQN
FRITDSDLGAGGAKTKYQANISAIRLLKQLEAEGLQASPDQQEVLSRYVGWGGLADAFDP
EKENWRAEYAELKELLTPEEYEAARASTLNAHYTSPTVIHAIYEALENMGFESGNILEPS
MGVGNFFGCLPESMQNSRLYGVELDSITGRIAKQLYPKADITVAGFETTDRRDFYDIAIG
NVPFGQYQVNDRAYNRLGFSIHDYFFAKTLDQVRPGGVIAFVTSRYTMDKQSPEVRRYIA
QRAELLGAIRLPNNAFKANAGTDVVSDIIFLQKRDCPIEIEPDWVHLGRNEDGFAINSYF
VEHPEMILGRQSSESTQYGRQDFTVEPIEGLELADQLHDAVKYIRGTYQAAELPELGDDE
ALSGSIPADPNVKNYSYTVVDGEVYYRQNSLMSRPALNATASERVKGLVGLRDCLHHLID
LQMDAMTPDSAIRQAQAELNTLYDSFTSKYGLINSRANALAFQDDSSYYLLCTLEELDEE
KQLKRKADIFTKRTIKPHEVVTSVDTPSEALALSISEKACVDLEYMQQLTGMDESSLVDG
LQGVIFRDPVKNEWQTADEYLSGNVRQKLREAEQAASADPAYLPNVEALRSSQPKDLDAS
EIEVRLGATWIDQKYIQQFMEETFEPPYYLRRSIQVHFSPFTAEWSISGKSQPSYNDINA
YMTYGTERANAYRILEDTLNLRDVRIYDTVTDPDGKERRVLNSKETTLAQQKQQAIKDAF
SEWIWKDPDRRQELVMRYNELFNSNRPREYDGSHITFSGMNPEIHLREHQLNAVAHILYG
GNTLLAHEVGAGKTFEMVAAAMESKRLGLCHKPMFVVPNHLTEQWASEFLRLYPSANILA
ATKKDFELKNRKKFCARIATGDYDAIIIGHSQFERIPVSMERQERLLREQIEEVTEGIEE
LKNSRAERFTIKSMERTKKGLETKLKKLLESGRKDDVVTFEELGVDRLYVDEAHAFKNLF
LYTKMRNVAGLSTTDAQKSSDMLLKCRYIDELTGGKGVVFATGTPVSNSMTELYTMMRYL
QHDTLQKKGLAHFDCWASTFGETTTAIELAPEGTGYRARTRFAKFFNLPELMTLFKEVAD
IKTSDQLHLPVPEAVYHNVVAQPTEIQQAMVQELSERAAKVHAGAVDASVDNMLRITTDG
RKLGLDQRIINPDLPDDPSSKVNMCVDNIYRIWDEGQADKLTQLVFCDLSTPKTGAPAAK
AAKAVGGNLDNPELHAVAGAVKDDPPEPEFTVYDDIREKLVARGIPREQIAFIHEANTEA
RKKELFAKVRSGQVRVLMGSTFKMGAGMNVQDRLVALHDLDAPWRPGDLEQRSGRIIRQG
NRNKQVHIFRYVTEATFDAYLWQTLENKQKFISQIMTSKSPVRSCEDIDETALSYAEIKA
LCAGDERIKEKMDLDVDVARLKLMKANHQSQQYRLEDNILRHFPEQIEQNKGFIAGFQAD
MQTLAEHPHPQDGFAGMTVRGDVLTDKENAGAALVDAMKEVKGLEPVPIGSYRGFQMSLT
LEDFGKQYVLTLKGKMSHRVELGKDPRGNLIRIDNALAGMETRLARVQEKLDSLYAQMET
AKAELGKPFPQEQELKEKSARLAQLNIELNIDDRTPMEAMAEIADSEPEVRPAVSAKSER
PSVLAKLHAPLPQRDSHPKQNETEKEVR

Enzyme Prediction     

No EC number prediction in MGYG000003689_00117.

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG4646	COG4646	1.13e-79	1736	2260	1	540	Adenine-specific DNA methylase, N12 class [Replication, recombination and repair].
COG4646	COG4646	1.37e-23	2390	2592	427	637	Adenine-specific DNA methylase, N12 class [Replication, recombination and repair].
pfam01624	MutS_I	5.31e-21	772	857	7	93	MutS domain I. This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam05188, pfam05192 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterized in.
PRK05399	PRK05399	4.01e-20	772	838	15	81	DNA mismatch repair protein MutS; Provisional
COG0249	MutS	3.89e-17	772	855	13	92	DNA mismatch repair ATPase MutS [Replication, recombination and repair].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ASV45029.1	0.0	1436	3066	1543	3228
QIW86704.1	0.0	1436	3060	1611	3284
QIW86628.1	0.0	1436	3060	1611	3284
AEY69616.1	0.0	1436	3025	1684	3330
AXF51455.1	0.0	1397	3010	1748	3398

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
1NG9_A	3.07e-09	772	838	17	83	ChainA, DNA mismatch repair protein MutS [Escherichia coli],1NG9_B Chain B, DNA mismatch repair protein MutS [Escherichia coli]
5AKB_A	3.07e-09	772	838	17	83	MutSin complex with the N-terminal domain of MutL - crystal form 1 [Escherichia coli K-12],5AKB_B MutS in complex with the N-terminal domain of MutL - crystal form 1 [Escherichia coli K-12],5AKB_E MutS in complex with the N-terminal domain of MutL - crystal form 1 [Escherichia coli K-12],5AKC_A MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_B MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_E MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_F MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_I MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKC_J MutS in complex with the N-terminal domain of MutL - crystal form 2 [Escherichia coli K-12],5AKD_A MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_B MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_E MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_F MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_I MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12],5AKD_J MutS in complex with the N-terminal domain of MutL - crystal form 3 [Escherichia coli K-12]
3K0S_A	3.07e-09	772	838	16	82	ChainA, DNA mismatch repair protein mutS [Escherichia coli K-12],3K0S_B Chain B, DNA mismatch repair protein mutS [Escherichia coli K-12]
1OH5_A	3.07e-09	772	838	17	83	THECRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A C:A MISMATCH [Escherichia coli],1OH5_B THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A C:A MISMATCH [Escherichia coli],1OH6_A THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN A:A MISMATCH [Escherichia coli],1OH6_B THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN A:A MISMATCH [Escherichia coli],1OH7_A THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A G:G MISMATCH [Escherichia coli],1OH7_B THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A G:G MISMATCH [Escherichia coli],1OH8_A THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN UNPAIRED THYMIDINE [Escherichia coli],1OH8_B THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN UNPAIRED THYMIDINE [Escherichia coli],1W7A_A ATP bound MutS [Escherichia coli],1W7A_B ATP bound MutS [Escherichia coli],2WTU_A Crystal structure of Escherichia coli MutS in complex with a 16 basepair oligo containing an A.A mismatch. [Escherichia coli],2WTU_B Crystal structure of Escherichia coli MutS in complex with a 16 basepair oligo containing an A.A mismatch. [Escherichia coli],3ZLJ_A CRYSTAL STRUCTURE OF FULL-LENGTH E.COLI DNA MISMATCH REPAIR PROTEIN MUTS D835R MUTANT IN COMPLEX WITH GT MISMATCHED DNA [Escherichia coli K-12],3ZLJ_B CRYSTAL STRUCTURE OF FULL-LENGTH E.COLI DNA MISMATCH REPAIR PROTEIN MUTS D835R MUTANT IN COMPLEX WITH GT MISMATCHED DNA [Escherichia coli K-12]
7OTO_A	3.08e-09	772	838	23	89	ChainA, DNA mismatch repair protein MutS [Escherichia coli K-12],7OTO_B Chain B, DNA mismatch repair protein MutS [Escherichia coli K-12],7OU0_A Chain A, DNA mismatch repair protein MutS [Escherichia coli K-12],7OU0_B Chain B, DNA mismatch repair protein MutS [Escherichia coli K-12],7OU4_A Chain A, DNA mismatch repair protein MutS [Escherichia coli],7OU4_B Chain B, DNA mismatch repair protein MutS [Escherichia coli]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q71TF8	5.25e-42	1454	2848	45	1617	Defense against restriction protein B OS=Escherichia phage P1 OX=2886926 GN=darB PE=3 SV=1
B8FJL5	3.04e-12	772	868	13	110	DNA mismatch repair protein MutS OS=Desulfatibacillum aliphaticivorans OX=218208 GN=mutS PE=3 SV=1
Q60BA1	5.11e-12	764	838	9	83	DNA mismatch repair protein MutS OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) OX=243233 GN=mutS PE=3 SV=1
Q24X61	5.13e-12	772	852	21	102	DNA mismatch repair protein MutS OS=Desulfitobacterium hafniense (strain Y51) OX=138119 GN=mutS PE=3 SV=1
Q1I659	6.71e-12	772	838	14	80	DNA mismatch repair protein MutS OS=Pseudomonas entomophila (strain L48) OX=384676 GN=mutS PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000048	0.000001	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000003689_00117.