dbCAN-seq: a database of CAZyme sequence and annotation

Basic Information help

Species

Agathobacter faecis

Lineage

Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Agathobacter; Agathobacter faecis

CAZyme ID

MGYG000003694_01226

CAZy Family

GH53

CAZyme Description

HTH-type transcriptional repressor PurR

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
621	MGYG000003694_4\|CGC4	71710.04	4.6313

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003694	3443393	Isolate	China	Asia

Gene Location

Start: 212480; End: 214345 Strand: +

Enzyme Prediction help

No EC number prediction in MGYG000003694_01226.

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd06267	PBP1_LacI_sugar_binding-like	3.49e-51	68	279	57	264	ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. Ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. In most cases, ligands are monosaccharide including lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. The LacI family of proteins consists of transcriptional regulators related to the lac repressor. In this case, the domain sugar binding changes the DNA binding activity of the repressor domain.
COG1609	PurR	1.21e-49	67	288	115	333	DNA-binding transcriptional regulator, LacI/PurR family [Transcription].
cd01949	GGDEF	5.50e-41	468	614	1	154	Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.
COG2199	GGDEF	1.06e-40	454	611	7	172	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants [Signal transduction mechanisms].
cd19975	PBP1_CcpA-like	9.80e-38	68	283	57	269	ligand-binding domain of putative DNA transcription regulators highly similar to that of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation. This group includes the ligand-binding domain of uncharacterized DNA transcription repressors highly similar to that of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation (CCR), a process in which enzymes necessary for the metabolism of alternative sugars are inhibited in the presence of glucose. In gram-positive bacteria, CCR is controlled by HPr, a phosphoenolpyruvate:sugar phsophotrasnferase system (PTS) and a transcriptional regulator CcpA. Moreover, CcpA can regulate sporulation and antibiotic resistance as well as play a role in virulence development of certain pathogens such as the group A streptococcus. The ligand binding domain of CcpA is a member of the LacI-GalR family of bacterial transcription regulators.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
CBK91062.1	2.11e-196	1	617	1	618
ACR74768.1	1.17e-195	1	617	1	618
CBK94002.1	6.55e-195	1	617	1	618
AWS42710.1	3.55e-15	72	283	595	802
AQZ65622.1	1.18e-12	71	244	573	744

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4ZVE_A	8.08e-19	470	607	2	147	Crystalstructure of GGDEF domain of the E. coli DosC - form I (apo-form) [Escherichia coli K-12],4ZVF_A Crystal structure of GGDEF domain of the E. coli DosC - form II (GTP-alpha-S-bound) [Escherichia coli K-12],4ZVG_A Crystal structure of GGDEF domain of the E. coli DosC - form III [Escherichia coli K-12],4ZVG_B Crystal structure of GGDEF domain of the E. coli DosC - form III [Escherichia coli K-12],4ZVH_A Crystal structure of GGDEF domain of the E. coli DosC - form IV [Escherichia coli K-12],4ZVH_B Crystal structure of GGDEF domain of the E. coli DosC - form IV [Escherichia coli K-12]
6ZXB_A	1.10e-18	444	610	108	284	ChainA, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXB_B Chain B, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)']
6ZXC_A	1.60e-18	444	610	133	309	ChainA, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXC_B Chain B, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXC_C Chain C, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXC_D Chain D, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)']
3I5C_A	1.78e-18	445	610	8	186	Crystalstructure of a fusion protein containing the leucine zipper of GCN4 and the GGDEF domain of WspR from Pseudomonas aeruginosa [Saccharomyces cerevisiae],3I5C_B Crystal structure of a fusion protein containing the leucine zipper of GCN4 and the GGDEF domain of WspR from Pseudomonas aeruginosa [Saccharomyces cerevisiae]
6ZXM_A	2.90e-18	444	610	133	309	ChainA, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_B Chain B, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_C Chain C, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_D Chain D, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_E Chain E, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_F Chain F, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)']

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
B7VMG4	1.69e-19	68	271	117	316	HTH-type transcriptional repressor PurR OS=Vibrio atlanticus (strain LGP32) OX=575788 GN=purR PE=3 SV=1
Q6LQB9	2.27e-19	95	271	140	316	HTH-type transcriptional repressor PurR OS=Photobacterium profundum (strain SS9) OX=298386 GN=purR PE=3 SV=2
Q8DAQ5	7.48e-19	68	271	117	316	HTH-type transcriptional repressor PurR OS=Vibrio vulnificus (strain CMCP6) OX=216895 GN=purR PE=3 SV=1
Q7MJ57	7.48e-19	68	271	117	316	HTH-type transcriptional repressor PurR OS=Vibrio vulnificus (strain YJ016) OX=196600 GN=purR PE=3 SV=1
P0ACN8	2.69e-18	48	268	104	320	HTH-type transcriptional repressor CytR OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) OX=199310 GN=cytR PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000054	0.000002	0.000000	0.000000	0.000000	0.000000

TMHMM Annotations help

There is no transmembrane helices in MGYG000003694_01226.

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