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CAZyme Information: MGYG000003715_01430
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Muricomes sp900604355 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Muricomes; Muricomes sp900604355 | |||||||||||
| CAZyme ID | MGYG000003715_01430 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Tyrocidine synthase 3 | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 52; End: 9009 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK12467 | PRK12467 | 0.0 | 1 | 1971 | 632 | 2606 | peptide synthase; Provisional |
| PRK05691 | PRK05691 | 0.0 | 232 | 2563 | 388 | 2779 | peptide synthase; Validated |
| PRK12316 | PRK12316 | 0.0 | 564 | 2560 | 1624 | 3623 | peptide synthase; Provisional |
| PRK12316 | PRK12316 | 0.0 | 6 | 1971 | 2124 | 4062 | peptide synthase; Provisional |
| cd12114 | A_NRPS_TlmIV_like | 0.0 | 965 | 1440 | 1 | 477 | The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QND46664.1 | 8.21e-227 | 14 | 2563 | 59 | 2666 |
| BAY90071.1 | 9.97e-157 | 1 | 2561 | 696 | 3285 |
| BAZ75991.1 | 1.32e-156 | 1 | 2561 | 697 | 3294 |
| BAZ00088.1 | 1.32e-156 | 1 | 2561 | 697 | 3294 |
| BAY30132.1 | 6.83e-156 | 1 | 2561 | 697 | 3296 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 7LY7_A | 9.46e-291 | 1550 | 2561 | 9 | 1018 | ChainA, BmdB, Bacillamide NRPS [Thermoactinomyces vulgaris] |
| 7LY4_E | 9.79e-291 | 1550 | 2561 | 9 | 1018 | ChainE, BmdB, bacillamide NRPS [Thermoactinomyces vulgaris] |
| 6MFZ_A | 4.30e-198 | 952 | 2566 | 202 | 1804 | Crystalstructure of dimodular LgrA in a condensation state [Brevibacillus parabrevis],6MFZ_B Crystal structure of dimodular LgrA in a condensation state [Brevibacillus parabrevis] |
| 6MFY_A | 5.76e-183 | 952 | 2479 | 202 | 1716 | Crystalstructure of a 5-domain construct of LgrA in the substrate donation state [Brevibacillus parabrevis],6MG0_A Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis],6MG0_B Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis] |
| 6LTA_A | 1.18e-140 | 1537 | 2535 | 42 | 1072 | ChainA, Nonribosomal peptide synthetase [Streptomyces sp. Sp080513GE-23],6LTB_A Chain A, Nonribosomal peptide synthetase [Streptomyces sp. Sp080513GE-23],6LTC_A Chain A, Nonribosomal peptide synthetase [Streptomyces sp. Sp080513GE-23],6LTD_A Chain A, Nonribosomal peptide synthetase [Streptomyces sp. Sp080513GE-23],6LTD_B Chain B, Nonribosomal peptide synthetase [Streptomyces sp. Sp080513GE-23] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| O68006 | 0.0 | 9 | 2543 | 158 | 2669 | Bacitracin synthase 1 OS=Bacillus licheniformis OX=1402 GN=bacA PE=3 SV=1 |
| P0C064 | 1.51e-302 | 29 | 2543 | 1647 | 4142 | Gramicidin S synthase 2 OS=Brevibacillus brevis OX=1393 GN=grsB PE=1 SV=2 |
| O30409 | 2.32e-298 | 29 | 2543 | 1641 | 4128 | Tyrocidine synthase 3 OS=Brevibacillus parabrevis OX=54914 GN=tycC PE=1 SV=1 |
| P0C063 | 1.97e-295 | 29 | 2543 | 1647 | 4143 | Gramicidin S synthase 2 OS=Aneurinibacillus migulanus OX=47500 GN=grsB PE=3 SV=2 |
| O30408 | 9.14e-288 | 27 | 2552 | 606 | 3103 | Tyrocidine synthase 2 OS=Brevibacillus parabrevis OX=54914 GN=tycB PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000053 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |