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CAZyme Information: MGYG000003717_01096

You are here: Home > Sequence: MGYG000003717_01096

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species
Lineage Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus;
CAZyme ID MGYG000003717_01096
CAZy Family GH73
CAZyme Description Putative endo-beta-N-acetylglucosaminidase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
750 MGYG000003717_21|CGC1 86395.22 8.4365
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003717 1753680 MAG Canada North America
Gene Location Start: 22797;  End: 25049  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.-

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH73 633 743 7.2e-27 0.96875

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG4193 LytD 5.52e-45 582 750 58 236
Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism].
COG5263 COG5263 7.25e-28 175 473 6 312
Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism].
smart00047 LYZ2 1.81e-23 626 750 7 147
Lysozyme subfamily 2. Eubacterial enzymes distantly related to eukaryotic lysozymes.
pfam17890 WW_like 9.35e-23 544 596 1 53
Peptidoglycan hydrolase LytB WW-like domain. Structural analysis revealed that the catalytic domain of LytB consists of three structurally independent modules: SH3b, WW domain-like, and the glycoside hydrolase family 73 (GH73). This entry is the WW like domain found in endo-beta-N-acetylglucosaminidase LytB from Streptococcus pneumoniae. Functional analysis show that the deletion of both SH3b and WW modules almost completely abolished the activity of LytB. Furthermore, it was shown that the SH3b and WW modules are indispensable for LytB in cell separation.
pfam18342 LytB_WW 1.29e-22 481 540 4 63
Endo-beta-N-acetylglucosaminidase LytB WW domain. This domain has can be found in endo-beta-N-acetylglucosaminidase LytB (EC 3.2.1.96) of S. pneumoniae and other gram positive bacteria. Comparative analysis revealed that the second all-beta module derived from the WW-like segments is structurally similar to the chitin binding domain of S. marcescens chitinase ChiB, implying a peptide binding function for this module.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
AHZ47906.1 0.0 1 750 1 750
QQL01282.1 0.0 1 750 1 750
QXW60772.1 0.0 1 750 1 750
QLL98572.1 0.0 1 750 1 750
QLL95967.1 0.0 1 750 1 750

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
4Q2W_A 2.78e-118 477 750 16 290
CrystalStructure of pneumococcal peptidoglycan hydrolase LytB [Streptococcus pneumoniae TIGR4]
2WW5_A 1.25e-21 176 348 44 258
3D-structureof the modular autolysin LytC from Streptococcus pneumoniae at 1.6 A resolution [Streptococcus pneumoniae R6],2WWD_A 3D-structure of the modular autolysin LytC from Streptococcus pneumoniae in complex with pneummococcal peptidoglycan fragment [Streptococcus pneumoniae R6]
2WWC_A 1.25e-21 176 348 44 258
3D-structureof the modular autolysin LytC from Streptococcus pneumoniae in complex with synthetic peptidoglycan ligand [Streptococcus pneumoniae R6]
4PI7_A 1.23e-17 596 749 52 218
ChainA, Autolysin E [Staphylococcus aureus subsp. aureus Mu50],4PI9_A Chain A, Autolysin E [Staphylococcus aureus subsp. aureus Mu50],4PIA_A Chain A, Autolysin E [Staphylococcus aureus subsp. aureus Mu50]
4PI8_A 7.62e-17 596 749 52 218
ChainA, Autolysin E [Staphylococcus aureus subsp. aureus Mu50]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P59205 2.54e-154 176 750 30 658
Putative endo-beta-N-acetylglucosaminidase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=lytB PE=1 SV=1
P59206 3.57e-147 176 750 30 702
Putative endo-beta-N-acetylglucosaminidase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=lytB PE=1 SV=1
Q99V41 4.18e-13 594 747 1064 1236
Bifunctional autolysin OS=Staphylococcus aureus (strain N315) OX=158879 GN=atl PE=1 SV=1
Q931U5 4.18e-13 594 747 1064 1236
Bifunctional autolysin OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) OX=158878 GN=atl PE=1 SV=2
Q5HH31 4.19e-13 594 747 1072 1244
Bifunctional autolysin OS=Staphylococcus aureus (strain COL) OX=93062 GN=atl PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000522 0.886311 0.112203 0.000366 0.000306 0.000259

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003717_01096.