CAZyme Information: MGYG000003764_00191

Basic Information

• Lineage: Bacteria; Campylobacterota; Campylobacteria; Campylobacterales; Campylobacteraceae; Campylobacter_B
• CAZyme ID: MGYG000003764_00191
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
943		106880.59	9.4907

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003764	1086320	MAG	Canada	North America

• Gene Location: Start: 1373; End: 4204 Strand: +

Full Sequence      

MKINSKQNLDASAISSVKFGVNSVKNQNLISTKFYVNLGKNQNLTHANSRANLTNPHKNF
TRKIARFFAKFTLILCLICAINFAIFLLLDYLFPLNLDALYRLQSEFLYDKNGREIAARL
AGDEIWRVDTDEIPPLLKKSAIYFEDRYFYEHFGVNFLSIIRASAHNLTHKNKIGASTIT
MQVARMMEPKKRSYSNKIIEIFRAFELEYHFSKDEILKFYFNLAPYGGNIEGAKMASRIY
FNRDLNELSIAQTALLSVVPKNPNANRLDRKSNIKRLKNRALKELFTHKIIDKSAYERGL
AEKNENRRYEIANLAPHYAQMAFKNGISHSNLDLNLQIPLTNLLKNHVNRLQNRGVKNAS
AIIIDNQKMSVVAYVGSHDLGAFLGENDGVASPKNVGSTLKPFIYANAIDAGLITPKSRL
IDTELHFGRYVPQNYLRDYNGEISASDALNFSLNIPATKLNLALGKNSIYETLKSSGIAL
NSKEFYGDSIALGAVEISLIDLALMYSAFSNKGAILPLEIAGEKRAKFVANLEIDSISEN
LMQKIDDNFMFWSKEFVKKNDFKQVEIGGKLSANSDLNFNQNLSMNANFQTSAQVYFLDK
FRNLDEEKQVNFNVDNLFKTMPQFNFVPNLVQKIDDLNKNLDLNFTPRWVEKFHQISPKF
YGNANQNFVQILSPQSAFITTKMLENANRAYLGSAWESANKPKIALKTGTSAGNRDLYAV
AFSKNFTIVVWMGNFNGAKTDGLTGSVSSAIVALEMFDEIAKNYDLGEFVSQDGVVMREV
CVDAFLGAGEAEKLDKNAKNLDENLNKNGLQCKKKAVDFYVKPIKRECDFYTQEELFFML
KNGLIDTQTLLKSVCASKFKNIRPLIAFPFDKEKIIAYDDETIVKFQCFSVFGDEIYMKI
EDRYEKLKNGAVKKLKMRVGSHKIGCLDEMSNFSESSYEVVKF

Enzyme Prediction     

No EC number prediction in MGYG000003764_00191.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	126	280	2.8e-46	0.8700564971751412

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02073	PBP_1c	6.16e-134	108	764	14	547	penicillin-binding protein 1C. This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG4953	PbpC	2.64e-131	73	795	3	598	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
COG0744	MrcB	2.21e-85	60	753	11	586	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	6.52e-79	128	762	5	526	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
PRK11240	PRK11240	1.67e-72	73	518	10	462	penicillin-binding protein 1C; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QKF71374.1	1.56e-219	66	943	2	723
QKF92081.1	2.91e-219	79	943	16	722
EAU00146.2	4.46e-216	80	940	17	722
ALF47642.1	3.33e-215	70	940	5	720
QKF61237.1	6.65e-215	80	940	15	720

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3DWK_A	6.35e-29	108	513	10	452	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
2OLU_A	4.39e-28	108	513	19	461	StructuralInsight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Apoenzyme [Staphylococcus aureus],2OLV_A Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus],2OLV_B Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus]
5FGZ_A	1.59e-22	122	518	153	580	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	1.65e-22	122	518	174	601	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]
3UDF_A	9.74e-21	115	513	29	539	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P76577	3.33e-52	123	513	60	459	Penicillin-binding protein 1C OS=Escherichia coli (strain K12) OX=83333 GN=pbpC PE=1 SV=1
P38050	6.30e-31	105	513	48	474	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
Q89AR2	2.73e-29	122	513	154	574	Penicillin-binding protein 1B OS=Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) OX=224915 GN=mrcB PE=3 SV=1
P70997	1.20e-28	104	513	53	484	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
Q9KUC0	2.87e-28	131	518	186	601	Penicillin-binding protein 1B OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=mrcB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000024	0.000009	0.000001	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
67	89