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CAZyme Information: MGYG000003792_01939

You are here: Home > Sequence: MGYG000003792_01939

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species
Lineage Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Brevibacteriaceae; Brevibacterium;
CAZyme ID MGYG000003792_01939
CAZy Family GT20
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
726 81301.67 5.9178
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003792 2144916 MAG Canada North America
Gene Location Start: 56;  End: 2236  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

EC 2.4.1.15

CAZyme Signature Domains help

Family Start End Evalue family coverage
GT20 10 452 3.2e-170 0.9284210526315789

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK14501 PRK14501 0.0 15 713 26 720
putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional
TIGR02400 trehalose_OtsA 0.0 12 453 18 456
alpha,alpha-trehalose-phosphate synthase [UDP-forming]. This enzyme catalyzes the key, penultimate step in biosynthesis of trehalose, a compatible solute made as an osmoprotectant in some species in all three domains of life. The gene symbol OtsA stands for osmotically regulated trehalose synthesis A. Trehalose helps protect against both osmotic and thermal stresses, and is made from two glucose subunits. This model excludes glucosylglycerol-phosphate synthase, an enzyme of an analogous osmoprotectant system in many cyanobacterial strains. This model does not identify archaeal examples, as they are more divergent than glucosylglycerol-phosphate synthase. Sequences that score in the gray zone between the trusted and noise cutoffs include a number of yeast multidomain proteins in which the N-terminal domain may be functionally equivalent to this family. The gray zone also includes the OtsA of Cornyebacterium glutamicum (and related species), shown to be responsible for synthesis of only trace amounts of trehalose while the majority is synthesized by the TreYZ pathway; the significance of OtsA in this species is unclear (see Wolf, et al., ). [Cellular processes, Adaptations to atypical conditions]
cd03788 GT20_TPS 0.0 12 452 23 463
trehalose-6-phosphate synthase. Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.
COG0380 OtsA 5.31e-172 12 457 39 483
Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism].
pfam00982 Glyco_transf_20 4.77e-166 12 453 26 470
Glycosyltransferase family 20. Members of this family belong to glycosyl transferase family 20. OtsA (Trehalose-6-phosphate synthase) is homologous to regions in the subunits of yeast trehalose-6-phosphate synthase/phosphate complex,.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QIN30508.1 2.62e-262 1 720 20 791
AWB95830.1 3.06e-257 12 721 40 738
QEO16281.1 9.01e-254 12 720 19 716
QAY73693.1 1.66e-251 12 713 39 729
SDS09838.1 2.62e-251 12 713 39 729

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
5JIJ_A 7.34e-168 11 463 33 486
ChainA, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5JIO_A Chain A, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5K41_A Chain A, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5K42_A Chain A, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5K44_A Chain A, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5K5C_A Chain A, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5L3K_A Chain A, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5L3K_B Chain B, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5L3K_C Chain C, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5L3K_D Chain D, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5L3K_E Chain E, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5L3K_F Chain F, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5L3K_G Chain G, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile],5L3K_H Chain H, Alpha,alpha-trehalose-phosphate synthase [Mycolicibacterium thermoresistibile]
5HUT_A 7.25e-90 12 451 27 467
Structureof Candida albicans trehalose-6-phosphate synthase in complex with UDP-glucose [Candida albicans SC5314],5HUT_B Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP-glucose [Candida albicans SC5314],5HUU_A Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and glucose-6-phosphate [Candida albicans SC5314],5HUU_B Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and glucose-6-phosphate [Candida albicans SC5314],5HVL_A Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and validoxylamine A [Candida albicans SC5314],5HVL_B Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and validoxylamine A [Candida albicans SC5314]
5HUV_A 3.92e-89 12 451 27 467
Structureof Candida albicans trehalose-6-phosphate synthase E341R/E346R in complex with UDP-glucose [Candida albicans SC5314],5HUV_B Structure of Candida albicans trehalose-6-phosphate synthase E341R/E346R in complex with UDP-glucose [Candida albicans SC5314]
5HVM_A 9.56e-85 15 478 38 500
Structureof Aspergillus fumigatus trehalose-6-phosphate synthase A in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293],5HVM_B Structure of Aspergillus fumigatus trehalose-6-phosphate synthase A in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293]
6JBI_A 4.98e-84 11 451 22 462
Structureof Tps1 apo structure [Pyricularia oryzae 70-15],6JBI_B Structure of Tps1 apo structure [Pyricularia oryzae 70-15],6JBR_A Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_B Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_D Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_F Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_H Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_K Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_M Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_O Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBW_A Structure of Tps1/UDP complex [Pyricularia oryzae 70-15],6JBW_B Structure of Tps1/UDP complex [Pyricularia oryzae 70-15]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
A0R4M9 7.64e-169 12 451 37 477
Trehalose-6-phosphate synthase OS=Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) OX=246196 GN=otsA PE=1 SV=1
A3Q6H9 4.37e-168 13 456 38 482
Trehalose-6-phosphate synthase OS=Mycobacterium sp. (strain JLS) OX=164757 GN=otsA PE=3 SV=1
Q1B321 7.60e-168 11 453 36 479
Trehalose-6-phosphate synthase OS=Mycobacterium sp. (strain MCS) OX=164756 GN=otsA PE=3 SV=1
A1UM30 7.60e-168 11 453 36 479
Trehalose-6-phosphate synthase OS=Mycobacterium sp. (strain KMS) OX=189918 GN=otsA PE=3 SV=1
A1TFL3 1.84e-166 12 451 37 483
Trehalose-6-phosphate synthase OS=Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1) OX=350058 GN=otsA PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000068 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003792_01939.