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CAZyme Information: MGYG000003806_01445
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Actinobacteriota; Actinomycetia; Mycobacteriales; Mycobacteriaceae; Corynebacterium; | |||||||||||
| CAZyme ID | MGYG000003806_01445 | |||||||||||
| CAZy Family | GT53 | |||||||||||
| CAZyme Description | putative arabinosyltransferase C | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 3845; End: 7189 Strand: - | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GT53 | 15 | 1107 | 0 | 0.9952335557673975 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam04602 | Arabinose_trans | 0.0 | 200 | 657 | 1 | 458 | Mycobacterial cell wall arabinan synthesis protein. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. |
| pfam14896 | Arabino_trans_C | 1.33e-179 | 707 | 1107 | 1 | 384 | EmbC C-terminal domain. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate. |
| pfam17689 | Arabino_trans_N | 9.47e-54 | 39 | 196 | 1 | 155 | Arabinosyltransferase concanavalin like domain. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. |
| COG1807 | ArnT | 7.04e-07 | 241 | 651 | 1 | 406 | 4-amino-4-deoxy-L-arabinose transferase or related glycosyltransferase of PMT family [Cell wall/membrane/envelope biogenesis]. |
| pfam11188 | DUF2975 | 0.007 | 192 | 261 | 8 | 73 | Protein of unknown function (DUF2975). This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QQU95999.1 | 0.0 | 1 | 1112 | 1 | 1112 |
| ACP31699.1 | 0.0 | 1 | 1114 | 1 | 1114 |
| QQU94079.1 | 0.0 | 1 | 1114 | 1 | 1114 |
| QRP59852.1 | 0.0 | 1 | 1114 | 1 | 1114 |
| QQA79138.1 | 0.0 | 1 | 1114 | 1 | 1114 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 7BVE_A | 7.77e-261 | 13 | 1108 | 13 | 1073 | Cryo-EMstructure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155],7BVE_B Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155] |
| 7BVH_A | 1.91e-260 | 13 | 1108 | 26 | 1086 | Crystalstructure of arabinosyltransferase EmbC2-AcpM2 complex from Mycobacterium smegmatis complexed with di-arabinose [Mycolicibacterium smegmatis MC2 155],7BVH_B Crystal structure of arabinosyltransferase EmbC2-AcpM2 complex from Mycobacterium smegmatis complexed with di-arabinose [Mycolicibacterium smegmatis MC2 155] |
| 7BWR_A | 7.85e-238 | 16 | 1110 | 27 | 1082 | Mycobacteriumsmegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric 'active state' [Mycolicibacterium smegmatis MC2 155],7BWR_B Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric 'active state' [Mycolicibacterium smegmatis MC2 155],7BX8_A Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric 'resting state' [Mycolicibacterium smegmatis MC2 155],7BX8_B Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric 'resting state' [Mycolicibacterium smegmatis MC2 155] |
| 6X0O_A | 1.27e-237 | 16 | 1110 | 27 | 1082 | Single-ParticleCryo-EM Structure of Arabinosyltransferase EmbB from Mycobacterium smegmatis [Mycolicibacterium smegmatis MC2 155] |
| 7BVC_B | 1.35e-237 | 16 | 1110 | 27 | 1082 | Cryo-EMstructure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155],7BVG_B Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with di-arabinose. [Mycolicibacterium smegmatis MC2 155] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q50393 | 2.18e-257 | 13 | 1108 | 13 | 1073 | Probable arabinosyltransferase C OS=Mycolicibacterium smegmatis OX=1772 GN=embC PE=3 SV=2 |
| Q7TVN4 | 1.06e-244 | 16 | 1107 | 30 | 1092 | Probable arabinosyltransferase C OS=Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) OX=233413 GN=embC PE=3 SV=1 |
| P9WNL5 | 5.91e-244 | 16 | 1107 | 30 | 1092 | Probable arabinosyltransferase C OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=embC PE=1 SV=1 |
| P9WNL4 | 8.34e-244 | 16 | 1107 | 30 | 1092 | Probable arabinosyltransferase C OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=embC PE=3 SV=1 |
| Q9CDA7 | 7.78e-241 | 16 | 1107 | 12 | 1069 | Probable arabinosyltransferase C OS=Mycobacterium leprae (strain TN) OX=272631 GN=embC PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.999991 | 0.000042 | 0.000000 | 0.000000 | 0.000000 | 0.000005 |
TMHMM Annotations download full data without filtering help
| start | end |
|---|---|
| 13 | 35 |
| 206 | 224 |
| 244 | 261 |
| 312 | 334 |
| 351 | 368 |
| 406 | 428 |
| 441 | 463 |
| 510 | 527 |
| 540 | 557 |
| 561 | 583 |
| 596 | 618 |
| 640 | 662 |
| 683 | 705 |