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CAZyme Information: MGYG000003810_00562
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Actinomycetaceae; Varibaculum; | |||||||||||
| CAZyme ID | MGYG000003810_00562 | |||||||||||
| CAZy Family | CBM32 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 53197; End: 60048 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH35 | 919 | 1254 | 2.9e-81 | 0.9837133550488599 |
| GH20 | 345 | 704 | 3.9e-74 | 0.973293768545994 |
| CBM32 | 54 | 186 | 3.9e-21 | 0.9274193548387096 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd06568 | GH20_SpHex_like | 4.81e-90 | 350 | 714 | 1 | 326 | A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the active site plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself. Proteins belonging to this subgroup lack the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. |
| cd06563 | GH20_chitobiase-like | 1.47e-79 | 350 | 715 | 1 | 355 | The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself. |
| pfam01301 | Glyco_hydro_35 | 7.52e-79 | 917 | 1255 | 1 | 315 | Glycosyl hydrolases family 35. |
| pfam00728 | Glyco_hydro_20 | 2.29e-71 | 350 | 704 | 1 | 345 | Glycosyl hydrolase family 20, catalytic domain. This domain has a TIM barrel fold. |
| COG3525 | Chb | 3.94e-59 | 193 | 726 | 122 | 637 | N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| AOZ72117.1 | 0.0 | 902 | 2196 | 61 | 1312 |
| QQM67568.1 | 0.0 | 902 | 2196 | 69 | 1345 |
| VEG55570.1 | 0.0 | 902 | 2175 | 70 | 1330 |
| QWW19060.1 | 0.0 | 902 | 2171 | 47 | 1303 |
| QGH69595.1 | 0.0 | 902 | 2167 | 68 | 1319 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6YXZ_JJJ | 7.87e-126 | 45 | 872 | 20 | 841 | ChainJJJ, Beta-N-acetylhexosaminidase [Bifidobacterium bifidum] |
| 6Z14_JJJ | 1.95e-125 | 45 | 872 | 20 | 841 | ChainJJJ, Beta-N-acetylhexosaminidase [Bifidobacterium bifidum] |
| 1HP4_A | 6.09e-64 | 195 | 739 | 21 | 511 | ChainA, Beta-n-acetylhexosaminidase [Streptomyces plicatus],1HP5_A Chain A, Beta-n-acetylhexosaminidase [Streptomyces plicatus],1JAK_A Chain A, Beta-N-acetylhexosaminidase [Streptomyces plicatus],1M01_A Chain A, Beta-N-acetylhexosaminidase [Streptomyces plicatus],5FCZ_A Chain A, B-N-acetylhexosaminidase [Streptomyces plicatus],5FD0_A Chain A, B-N-acetylhexosaminidase [Streptomyces plicatus] |
| 1M04_A | 2.78e-63 | 195 | 739 | 21 | 511 | ChainA, Beta-N-acetylhexosaminidase [Streptomyces plicatus] |
| 1M03_A | 6.90e-63 | 195 | 739 | 21 | 511 | ChainA, Beta-N-acetylhexosaminidase [Streptomyces plicatus] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q4WG05 | 1.41e-63 | 911 | 1269 | 42 | 401 | Probable beta-galactosidase E OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=lacE PE=3 SV=1 |
| B0XXE7 | 1.41e-63 | 911 | 1269 | 42 | 401 | Probable beta-galactosidase E OS=Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) OX=451804 GN=lacE PE=3 SV=1 |
| A1DJ58 | 3.33e-63 | 911 | 1269 | 42 | 401 | Probable beta-galactosidase E OS=Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) OX=331117 GN=lacE PE=3 SV=1 |
| Q700S9 | 5.82e-62 | 911 | 1269 | 46 | 401 | Beta-galactosidase A OS=Penicillium sp. OX=5081 GN=lacA PE=1 SV=1 |
| Q5BFC4 | 7.46e-62 | 911 | 1269 | 46 | 400 | Probable beta-galactosidase A OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=lacA PE=3 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000347 | 0.998868 | 0.000179 | 0.000236 | 0.000177 | 0.000154 |
