CAZyme Information: MGYG000003813_00121

Basic Information

• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae; Porphyromonas
• CAZyme ID: MGYG000003813_00121
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
373		42125.22	9.9734

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003813	1684285	MAG	Canada	North America

• Gene Location: Start: 21116; End: 22237 Strand: -

Full Sequence      

MRYFLVAGEASGDLHAGELIKSLRKVDPDAVFAFMGGAAMEKAAACKPVLHYSAIAYMGF
LSVLKHYGTIRKAARQVQQQMLHFAPDCLIVVDSSGFNLRYILPFATKKLPQTKRFYYIA
PKVWAWQSKRIRKIRKYCHLVLSILPFEENYFRSRSVPCCYVGNPTREELLPEYLNSRDP
IRGMDHKELIALLPGSRRQEIRNNLQQMVRVANSFPSYHFTIAAAPGIEDNFYYPFLEKN
ITIVRDSTYSLLAKARAALVTSGTATLETALIGTPQVVVYRLNGLRIVNILFRILMHIPY
FSLVNLIAGRKVVAELLAADASVQRITSELDKLLQPSAERALIDGYNEVYRALGTKQASS
EAAKCIFCYRLRG

Enzyme Prediction     

No EC number prediction in MGYG000003813_00121.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	4	352	2.3e-102	0.9858757062146892

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0763	LpxB	2.23e-99	1	367	2	376	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
PRK00025	lpxB	9.92e-97	1	366	2	371	lipid-A-disaccharide synthase; Reviewed
pfam02684	LpxB	2.04e-75	4	366	2	370	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
TIGR00215	lpxB	3.04e-62	5	364	10	380	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
PRK14089	PRK14089	2.95e-51	1	307	1	286	lipid-A-disaccharide synthase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QUI91423.1	1.63e-106	1	366	1	369
QUI89478.1	1.63e-106	1	366	1	369
ATS09476.1	3.27e-106	1	366	1	369
ALO28862.1	4.63e-106	1	366	1	369
ATS02318.1	6.56e-106	1	366	1	369

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8S_A	1.13e-32	5	366	11	377	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]
5W8N_A	3.01e-32	5	366	11	377	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
B3E4H8	4.36e-54	2	351	8	353	Lipid-A-disaccharide synthase OS=Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) OX=398767 GN=lpxB PE=3 SV=1
Q1D393	7.98e-50	2	366	6	374	Lipid-A-disaccharide synthase OS=Myxococcus xanthus (strain DK1622) OX=246197 GN=lpxB PE=3 SV=1
Q39T49	2.25e-49	2	363	8	373	Lipid-A-disaccharide synthase OS=Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15) OX=269799 GN=lpxB PE=3 SV=1
A3QG90	1.62e-48	3	366	9	375	Lipid-A-disaccharide synthase OS=Shewanella loihica (strain ATCC BAA-1088 / PV-4) OX=323850 GN=lpxB PE=3 SV=1
Q74AT9	1.70e-48	2	363	8	373	Lipid-A-disaccharide synthase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) OX=243231 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000056	0.000002	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000003813_00121.