CAZyme Information: MGYG000003878_01406

Basic Information

• Species: Prevotella oris
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Prevotella; Prevotella oris
• CAZyme ID: MGYG000003878_01406
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
625		71101.89	8.0668

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003878	2959023	MAG	United States	North America

• Gene Location: Start: 18741; End: 20618 Strand: -

Full Sequence      

MLQKPIEWVIAVKLERNYTKEEIIALYLNYFDFLHNAVGIKTAANTYFNKEANDLNVVES
AMLIGLCKNPSLFNPVRFPDRARNRRNVVLGQMLKAGYLSKAEFEEYCAMPIALNFHRTD
HKDGNATYFREFLRQYMMAEKPDRANYPSWNRVQYTLDSIAWENNPLYGWCNKNFKKDGK
PYNIYTDGLKIYTTIDSRMQQYAEESVYGHVAKFLQPAFNKANRNKKNAPFSGSLTLSQV
RSILNRNMFQSERYRNMKAAGASDAEIRAAFNRPVDMTIFTYHGDIDTVMTPMDSIKYYK
GFLRAGFMSMDPKTGAVKAYVGGLDYNHFMYDMVTGGRRQVGSTIKPFLYALAMENGFSP
CDLVPNVQKTYMVAGRAWTPRNASHARYGQMVTLKWGLAQSNNWISAYLMSKLNPQQFVS
TLHEFGIDNPDIHPSMSLCLGPCDVSVAEMVSAYSTFANHGIRTAPMFVSRIEDNEGNVI
ASFQPRMNEVISVESANKMLVLLQGVVDGGTASRLRYKYHMEGEICGKTGTTNKNSDAWF
MGFTPQLVTGIWVGGEDRDIHFDNISMGQGATMALPIWAYFMKKIYRDKSLNYSSNATFE
LPDGFDPCSKQDADNDEFQIDEVYE

Enzyme Prediction     

No EC number prediction in MGYG000003878_01406.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	3	93	1.6e-31	0.5084745762711864

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG5009	MrcA	2.77e-124	7	604	144	732	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	1.86e-120	7	588	79	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	1.41e-111	2	590	149	601	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	1.22e-72	1	583	137	782	penicillin-binding protein 1a; Provisional
TIGR02073	PBP_1c	1.98e-49	2	578	105	536	penicillin-binding protein 1C. This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
VEH15485.1	0.0	1	625	146	770
BCS86470.1	0.0	1	625	129	753
QUB46651.1	0.0	1	625	146	770
ALO48822.1	0.0	1	625	146	770
EFC70376.1	0.0	1	625	146	770

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3UDF_A	2.45e-63	3	582	112	712	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
4OON_A	1.70e-59	7	592	116	729	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3ZG8_B	1.17e-48	13	559	2	436	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3ZG7_B	5.01e-43	13	559	2	436	CrystalStructure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the apo form [Listeria monocytogenes]
5U2G_A	4.07e-41	1	589	111	761	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O66874	1.50e-68	7	602	140	679	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
O87626	7.73e-65	7	582	145	701	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
O87579	1.13e-60	7	583	145	703	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
P0A0Z5	2.94e-60	7	589	145	709	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) OX=122587 GN=mrcA PE=3 SV=1
P0A0Z6	2.94e-60	7	589	145	709	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup B (strain MC58) OX=122586 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000050	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000003878_01406.