CAZyme Information: MGYG000003951_00206

Basic Information

• Species: UMGS1611 sp900553435
• Lineage: Bacteria; Firmicutes; Bacilli; RF39; UBA660; UMGS1611; UMGS1611 sp900553435
• CAZyme ID: MGYG000003951_00206
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
921		102481.66	5.7481

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003951	941238	MAG	United Kingdom	Europe

• Gene Location: Start: 1121; End: 3886 Strand: -

Full Sequence      

MAYKVRRVNKITRAAKNAKEKVKNKARSAKDAYNREKKKKSFWYYFWTILIGFFILLFLL
FIVFAIYIIFSAPAFDPDNLYQKEASVIYDKDGKQIASLGSEKREKVAYEDLPEVLLDAI
IATEDSRYFQHNGFDLPRFMKASAGQLLGNSDAGGASTLTMQVVKNNFTSTESSGFAGIV
RKFTDIYMSIFKVEKNYTKEEIIEFYVNAPYLGSGSYGVEQASQTFFGKSVKDLSLVEAA
TIAGLFQAPGAYDPYVYPEKAQERRDQVLSLMERHGYITSEEKEIAEEIPVESYLNTSGS
ANPSLNKYQGFVDTVVQEVIDKTGNNPYDASMEIYTTMDRSKQDAINDLYAGKTYTFVDN
KVQLGITAIDNETGAIVAVGAGRNKTKELSFNYATMTDKHPGSTAKPIFDYGPGFECEKW
STYTPFFDEPTTYSGGDSINNWDRSYQGMLTLKDALSRSRNTTALQAFRETSNECKVKFV
KALGIRAEFGEDDVLHEAHSIGAFTGASPTELAAAYSAFANGGYYTEPYSYTKIVYKDSG
KEVEVKPKKERAMSAETAYLITNVLVSATSHNRVYSTQVATKTGTSSYEEEALRKHNVPS
SAIQSSWVSFYSPGISVTFWYGYDKLSSDYYLTMDSASYQRGLIQDALTAGLVEENGKFT
RPSSIVSSEVELETIPALKSSEYTPASLRGTFLFIKGSEPTETSTRFSKLNNVTNLNVSK
TGNTAKISWSKVKTPDFADKSYLQNYFKTGYKSYATKYYNKRISYNNAYMGNFGYDVYVK
VNGSLRKIGFTTNNSYTFDIPSGTTAVVVKTAYSKFKTNASSGVEKSLQGATIDITVNGD
GKTLKVGDTFIDEDPPVSIDADGTTIDPTEYEVTISEIKRSDGKVVTIDTLTEEAGTYTI
TYKITYNSNTYTETKTIEVTE

Enzyme Prediction     

No EC number prediction in MGYG000003951_00206.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	92	273	1.5e-54	0.9943502824858758

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	2.33e-131	65	712	35	661	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	2.97e-87	65	704	24	768	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
pfam00912	Transgly	2.65e-67	92	273	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
COG4953	PbpC	2.89e-56	65	587	14	513	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	1.06e-47	88	548	50	609	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QGQ46655.1	1.06e-143	68	730	62	722
QNF30636.1	2.57e-143	68	730	62	723
APH04640.1	2.00e-142	68	730	57	714
QNG61477.1	2.97e-140	71	710	63	694
AYA76804.1	7.94e-140	67	719	58	711

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3DWK_A	1.71e-87	88	668	10	605	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
2OLU_A	9.18e-85	71	668	2	614	StructuralInsight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Apoenzyme [Staphylococcus aureus],2OLV_A Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus],2OLV_B Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus]
3ZG8_B	3.35e-58	192	652	2	461	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3ZG7_B	5.91e-55	192	652	2	461	CrystalStructure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the apo form [Listeria monocytogenes]
3UDF_A	2.61e-42	88	536	23	559	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P39793	2.69e-126	71	709	62	700	Penicillin-binding protein 1A/1B OS=Bacillus subtilis (strain 168) OX=224308 GN=ponA PE=1 SV=1
Q00573	2.29e-95	66	625	33	602	Penicillin-binding protein 1A (Fragment) OS=Streptococcus oralis OX=1303 GN=ponA PE=3 SV=1
Q04707	6.41e-92	67	625	34	601	Penicillin-binding protein 1A OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=ponA PE=1 SV=2
Q8DR59	1.72e-91	67	625	34	601	Penicillin-binding protein 1A OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=pbpA PE=1 SV=1
P38050	3.28e-80	76	684	39	630	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999768	0.000247	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
43	65