CAZyme Information: MGYG000003992_02075

Basic Information

• Species: 43-108 sp001915545
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; 43-108; 43-108 sp001915545
• CAZyme ID: MGYG000003992_02075
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
385		43215.23	9.4613

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003992	3355495	MAG	United Kingdom	Europe

• Gene Location: Start: 4965; End: 6122 Strand: -

Full Sequence      

MKYYIIAGEASGDLHASNLMKALIAEDSVAEFRFYGGDKMQAVGGTLVRHYRNLAYMGFI
PVVMHLRTILSNMSRCKKDIVAWNPDVVILVDYPGFNLSIAEYISANTSIPVYYYISPKI
WAWKEYRIKTIRKCVSEMFSILPFEVDFYRRHDYPIHYVGNPCVDAVQEYLDKSASDTFT
DFTRTNGLSSKPVIALLAGSRKQEIKDNLPQMIEAASAFRDYQLVVAGAPGIDKDYYGQF
IPESADVKLVFGQTYRILRHSTAALVTSGTATLETAILSVPQVVCYYIRAGKLISFLRKL
FLHVPYISLANLILNKEAVTELVADRMNVDNLRSELKMILPGGSRLDGMRADYSALHKIL
GPAGASTKAARIMVKLLTERNKTKK

Enzyme Prediction     

No EC number prediction in MGYG000003992_02075.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	4	360	1.6e-108	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK00025	lpxB	8.84e-97	1	382	2	380	lipid-A-disaccharide synthase; Reviewed
COG0763	LpxB	4.29e-93	1	377	2	379	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
pfam02684	LpxB	1.66e-72	4	345	2	344	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
TIGR00215	lpxB	6.25e-63	5	373	10	383	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
PRK14089	PRK14089	2.23e-47	1	332	2	309	lipid-A-disaccharide synthase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QQY38221.1	6.05e-178	1	377	1	377
ABR39591.1	6.05e-178	1	377	1	377
QUT59470.1	1.22e-177	1	377	1	377
QQY41518.1	1.22e-177	1	377	1	377
QEW38059.1	7.01e-177	1	377	1	377

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8S_A	7.82e-35	5	376	11	380	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]
5W8N_A	2.08e-34	5	376	11	380	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q1D393	5.86e-63	5	377	9	378	Lipid-A-disaccharide synthase OS=Myxococcus xanthus (strain DK1622) OX=246197 GN=lpxB PE=3 SV=1
Q2LVL8	1.16e-62	5	377	8	378	Lipid-A-disaccharide synthase OS=Syntrophus aciditrophicus (strain SB) OX=56780 GN=lpxB PE=3 SV=1
Q39T49	3.56e-57	5	380	11	383	Lipid-A-disaccharide synthase OS=Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15) OX=269799 GN=lpxB PE=3 SV=1
Q74AT9	2.73e-56	5	377	11	380	Lipid-A-disaccharide synthase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) OX=243231 GN=lpxB PE=3 SV=1
Q6ALW0	2.20e-55	5	377	14	386	Lipid-A-disaccharide synthase OS=Desulfotalea psychrophila (strain LSv54 / DSM 12343) OX=177439 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000056	0.000001	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000003992_02075.