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CAZyme Information: MGYG000003993_01410

You are here: Home > Sequence: MGYG000003993_01410

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Alistipes sp900550925
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Alistipes sp900550925
CAZyme ID MGYG000003993_01410
CAZy Family GH18
CAZyme Description Chitinase A1
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
339 MGYG000003993_7|CGC2 37429.73 6.0373
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003993 1895769 MAG United Kingdom Europe
Gene Location Start: 65642;  End: 66661  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000003993_01410.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH18 45 334 3.3e-67 0.8817567567567568

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06548 GH18_chitinase 6.27e-89 49 322 26 322
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
pfam00704 Glyco_hydro_18 1.64e-71 32 322 2 307
Glycosyl hydrolases family 18.
smart00636 Glyco_18 1.49e-70 45 322 22 334
Glyco_18 domain.
cd02872 GH18_chitolectin_chitotriosidase 3.85e-66 45 327 24 346
This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.
COG3325 ChiA 4.46e-51 20 332 29 432
Chitinase, GH18 family [Carbohydrate transport and metabolism].

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
ADV45176.1 9.31e-124 1 339 1 342
QIK56154.1 3.93e-123 3 339 2 348
QIK61506.1 3.19e-122 3 339 2 348
ATP56025.1 3.69e-122 5 339 9 342
SCD19272.1 1.78e-120 26 337 31 342

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
6TSB_AAA 5.08e-52 31 317 37 332
ChainAAA, Peroxiredoxin [Clostridioides difficile 630]
6T9M_AAA 8.03e-52 31 317 56 351
ChainAAA, Peroxiredoxin [Clostridioides difficile 630]
6INX_A 2.64e-49 49 336 27 342
Structuralinsights into a novel glycoside hydrolase family 18 N-acetylglucosaminidase from Paenibacillus barengoltzii [Paenibacillus barengoltzii]
3QOK_A 5.95e-47 49 329 54 410
ChainA, Putative chitinase II [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
4NZC_A 7.32e-47 45 324 30 385
Crystalstructure of Chitinase D from Serratia proteamaculans at 1.45 Angstrom resolution [Serratia proteamaculans 568],4Q22_A Crystal structure of Chitinase D from Serratia proteamaculans in complex with N-acetyl glucosamine at 1.93 Angstrom resolution [Serratia proteamaculans 568]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P20533 1.54e-43 18 332 93 447
Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1
P36362 6.61e-36 39 326 43 379
Endochitinase OS=Manduca sexta OX=7130 PE=2 SV=1
Q13231 1.00e-31 45 326 47 367
Chitotriosidase-1 OS=Homo sapiens OX=9606 GN=CHIT1 PE=1 SV=1
Q9W092 3.22e-31 29 329 40 396
Probable chitinase 2 OS=Drosophila melanogaster OX=7227 GN=Cht2 PE=1 SV=1
Q95M17 7.36e-31 45 330 47 373
Acidic mammalian chitinase OS=Bos taurus OX=9913 GN=CHIA PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as LIPO

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000000 0.000056 0.999994 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003993_01410.