CAZyme Information: MGYG000004049_00295

Basic Information

• Lineage: Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Acutalibacteraceae; UMGS1484
• CAZyme ID: MGYG000004049_00295
• CAZy Family: GH125
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
426		48322.94	5.9828

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000004049	1758425	MAG	United Kingdom	Europe

• Gene Location: Start: 21073; End: 22353 Strand: -

Full Sequence      

MYLEEIKKEAQSIALRLKKSALPKAAEVFEKCFPVTAETTVKTASKDDTFLITGDIPAMW
LRDSTAQVICYLPLAKKSASAADFIEGLCKRQFKCICHDPYANAYNEREDGGHCNDDDNC
DDPLIWERKYEVDSLCYAVKLSYDFYKATGRTAHFNGTFFEGAKKILTLFEKEQYHKEKS
DYKFIRPNTAEHDTMPKNGEGNPVGFTGMTWSGFRPSDDRCFYNYLIPSNMFAAVELLHL
AEIFEKIAKDGRLSQKCRTLSAEIRQGIKNFGCVVHEKFGKMYAYETDGLGNYILSDDAN
VPSLLSAPYLGFCSKNDPVYEATRDFVLSKDNPFYFEGKYAKGVGSPHTPKNYVWHIALS
MQGLTAKDKDEKLSLLKMLVSTTDGTDLMHEGFDVNDPSKYTRPWFAWSCSLFCEFVMHC
LDEGVI

Enzyme Prediction     

No EC number prediction in MGYG000004049_00295.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH125	24	418	2.6e-166	0.9925373134328358

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG3538	COG3538	0.0	23	422	25	424	Meiotically up-regulated gene 157 (Mug157) protein (function unknown) [Function unknown].
pfam06824	Glyco_hydro_125	0.0	23	418	2	416	Metal-independent alpha-mannosidase (GH125). This family, which contains bacterial and fungal glycoside hydrolases, is also known as GH125. They function as metal-independent alpha-mannosidases, with specificity for alpha-1,6-linked non-reducing terminal mannose residues. Structurally this family is part of the 6 hairpin glycosidase superfamily.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QNF27513.1	2.67e-164	24	418	25	419
ASN07283.1	2.33e-163	24	418	17	411
QZN88343.1	2.18e-162	23	425	26	427
ASK62216.1	1.20e-160	24	418	25	419
QGH33695.1	6.47e-159	23	424	25	426

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6RQK_A	3.72e-151	24	417	27	419	Crystalstructure of GH125 1,6-alpha-mannosidase from Clostridium perfringens in complex with mannoimidazole [Clostridium perfringens str. 13],6RQK_B Crystal structure of GH125 1,6-alpha-mannosidase from Clostridium perfringens in complex with mannoimidazole [Clostridium perfringens str. 13]
3QT3_A	5.70e-151	24	417	27	419	Analysisof a New Family of Widely Distributed Metal-independent alpha-Mannosidases Provides Unique Insight into the Processing of N-linked Glycans, Clostridium perfringens CPE0426 apo-structure [Clostridium perfringens],3QT9_A Analysis of a new family of widely distributed metal-independent alpha mannosidases provides unique insight into the processing of N-linked glycans, Clostridium perfringens CPE0426 complexed with alpha-1,6-linked 1-thio-alpha-mannobiose [Clostridium perfringens]
5M7I_A	2.13e-150	24	417	27	419	Crystalstructure of GH125 1,6-alpha-mannosidase mutant from Clostridium perfringens in complex with 1,6-alpha-mannobiose [Clostridium perfringens str. 13],5M7Y_A Crystal structure of GH125 1,6-alpha-mannosidase mutant from Clostridium perfringens in complex with 1,6-alpha-mannotriose [Clostridium perfringens str. 13]
2NVP_A	3.70e-146	24	417	27	419	X-RayCrystal Structure of Protein CPF_0428 from Clostridium perfringens. Northeast Structural Genomics Consortium Target CpR63. [Clostridium perfringens]
3QPF_A	1.52e-135	1	422	2	424	Analysisof a New Family of Widely Distributed Metal-independent alpha-Mannosidases Provides Unique Insight into the Processing of N-linked Glycans, Streptococcus pneumoniae SP_2144 apo-structure [Streptococcus pneumoniae],3QPF_B Analysis of a New Family of Widely Distributed Metal-independent alpha-Mannosidases Provides Unique Insight into the Processing of N-linked Glycans, Streptococcus pneumoniae SP_2144 apo-structure [Streptococcus pneumoniae],3QRY_A Analysis of a new family of widely distributed metal-independent alpha mannosidases provides unique insight into the processing of N-linked glycans, Streptococcus pneumoniae SP_2144 1-deoxymannojirimycin complex [Streptococcus pneumoniae],3QRY_B Analysis of a new family of widely distributed metal-independent alpha mannosidases provides unique insight into the processing of N-linked glycans, Streptococcus pneumoniae SP_2144 1-deoxymannojirimycin complex [Streptococcus pneumoniae],3QSP_A Analysis of a new family of widely distributed metal-independent alpha mannosidases provides unique insight into the processing of N-linked glycans, Streptococcus pneumoniae SP_2144 non-productive substrate complex with alpha-1,6-mannobiose [Streptococcus pneumoniae],3QSP_B Analysis of a new family of widely distributed metal-independent alpha mannosidases provides unique insight into the processing of N-linked glycans, Streptococcus pneumoniae SP_2144 non-productive substrate complex with alpha-1,6-mannobiose [Streptococcus pneumoniae]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q10449	1.53e-90	26	423	81	499	Meiotically up-regulated gene 157 protein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=mug157 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000070	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000004049_00295.