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CAZyme Information: MGYG000004128_00930

You are here: Home > Sequence: MGYG000004128_00930

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species UMGS1253 sp900550065
Lineage Bacteria; Firmicutes_A; Clostridia; Monoglobales_A; UMGS1253; UMGS1253; UMGS1253 sp900550065
CAZyme ID MGYG000004128_00930
CAZy Family PL21
CAZyme Description Heparin and heparin-sulfate lyase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
759 85697.03 4.7338
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000004128 2239270 MAG United Kingdom Europe
Gene Location Start: 10971;  End: 13250  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000004128_00930.

CAZyme Signature Domains help

Family Start End Evalue family coverage
PL21 395 459 1.8e-26 0.9444444444444444

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
pfam07940 Hepar_II_III 0.001 401 455 31 85
Heparinase II/III-like protein. This family features sequences that are similar to a region of the Flavobacterium heparinum proteins heparinase II and heparinase III. The former is known to degrade heparin and heparin sulphate, whereas the latter predominantly degrades heparin sulphate. Both are secreted into the periplasmic space upon induction with heparin.
pfam18675 HepII_C 0.002 679 751 9 82
Heparinase II C-terminal domain. Heparinase II (HepII) is an 85-kDa dimeric enzyme that depolymerizes both heparin and heparan sulfate glycosaminoglycans. The protein is composed of three domains: an N-terminal alpha-helical domain, a central two-layered beta-sheet domain, and a C-terminal domain forming a two-layered beta-sheet. The C-terminal domain contains nine beta-strands packed together in a manner resembling a beta-barrel.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
BCI63941.1 7.06e-177 17 756 35 790
BCI63940.1 1.20e-167 25 757 47 793
BBH20141.1 1.26e-165 13 751 228 952
QDG70382.1 5.31e-143 4 746 190 948
QOU74174.1 2.68e-142 4 746 170 928

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
2FUQ_A 5.66e-137 6 751 9 741
ChainA, heparinase II protein [Pedobacter heparinus],2FUQ_B Chain B, heparinase II protein [Pedobacter heparinus]
3E80_A 5.99e-137 6 751 11 743
Structureof Heparinase II complexed with heparan sulfate degradation disaccharide product [Pedobacter heparinus],3E80_B Structure of Heparinase II complexed with heparan sulfate degradation disaccharide product [Pedobacter heparinus],3E80_C Structure of Heparinase II complexed with heparan sulfate degradation disaccharide product [Pedobacter heparinus]
3E7J_A 3.92e-134 6 751 11 743
ChainA, Heparinase II protein [Pedobacter heparinus],3E7J_B Chain B, Heparinase II protein [Pedobacter heparinus]
2FUT_A 9.68e-131 6 751 10 742
ChainA, heparinase II protein [Pedobacter heparinus],2FUT_B Chain B, heparinase II protein [Pedobacter heparinus]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
C6XZB6 6.18e-136 6 751 34 766
Heparin and heparin-sulfate lyase OS=Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3) OX=485917 GN=hepB PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000079 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000004128_00930.