CAZyme Information: MGYG000004187_00864

Basic Information

• Lineage: Bacteria; Proteobacteria; Gammaproteobacteria; Burkholderiales; Burkholderiaceae; Sutterella
• CAZyme ID: MGYG000004187_00864
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1C

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
636	MGYG000004187_102|CGC1	69014.9	9.2491

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000004187	2011841	MAG	United Kingdom	Europe

• Gene Location: Start: 3528; End: 5438 Strand: -

Full Sequence      

MLWALRYDMHYTKDEILTAYLSVTPYGGNVEGIEAASLVYFGKHASQLTAAESIALSVVP
QNPVKRHPVTGTDFDRARLAAGRKAIEEGFVSPRLRPAVEGPLKARSARELPFEAPHFTR
LVEGVRPAPVLKTTLSLSIQNAMEKILSESVARLRPYGVENGAMLVVDSRDMSVLAQVGS
VDFFASDIAGEVDGTRAPRSPGSTLKPFIYGLALDQGLIHSRSILLDARKSFRGYEPGNA
DKKFRGPLPAVEALNDSRNVPAVTLAGALRPDLYDFLREAGVPLKHPREHYGLSIVLGGA
EASAEDLARLYGTLGNGGLLRPLVRLQDEEPAAARPMLSPEAAWIVRRMLADGGETLKVE
GVPVPLLWKTGTSNGFRDAWTAGYAGRWIIVVWLGNFNGRPDPWLQGALVAQPVFRSAAV
RLLTDRAFAMSGEELKRFEAQPRNVVSEPVCRSTGDLALDAQGRVRCTDTVNAWFIPGVS
PIRDTGFLKEILIDEATGLRACKEGEGTKRIFVESWPSEYQERFLEAGVIKAPLPDWKPE
CRPEGAVSGTPPAILSPRAGTRYYTGTAGLKQAGIALKASLAPDARLVYWFAGDRFIGAA
KAGGTVVWQADPGTHRVSAVDDLGRRSQRTVTVRQP

Enzyme Prediction     

No EC number prediction in MGYG000004187_00864.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	1	73	2.1e-19	0.4067796610169492

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02073	PBP_1c	4.47e-173	1	633	111	726	penicillin-binding protein 1C. This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG4953	PbpC	1.09e-154	1	633	135	731	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
PRK11240	PRK11240	2.87e-91	2	624	139	762	penicillin-binding protein 1C; Provisional
COG0744	MrcB	1.50e-71	1	425	155	599	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	2.00e-69	1	417	80	523	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QDA55368.1	9.95e-200	4	635	181	811
BBF22797.1	7.72e-197	1	635	143	801
QQS90091.1	1.53e-191	4	635	215	861
QCC84882.1	4.20e-162	1	634	171	792
QTO41888.1	2.33e-161	1	634	147	768

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2JE5_A	2.89e-16	4	455	135	662	StructuralAnd Mechanistic Basis Of Penicillin Binding Protein Inhibition By Lactivicins [Streptococcus pneumoniae R6],2JE5_B Structural And Mechanistic Basis Of Penicillin Binding Protein Inhibition By Lactivicins [Streptococcus pneumoniae R6]
4OON_A	1.65e-15	1	455	117	747	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	1.57e-12	4	415	120	708	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
2JCH_A	6.70e-11	131	455	62	405	Structuraland mechanistic basis of penicillin binding protein inhibition by lactivicins [Streptococcus pneumoniae R6]
2XD1_A	7.28e-11	131	455	93	436	ACTIVESITE RESTRUCTURING REGULATES LIGAND RECOGNITION IN CLASS A PENICILLIN-BINDING PROTEINS [Streptococcus pneumoniae R6],2XD1_B ACTIVE SITE RESTRUCTURING REGULATES LIGAND RECOGNITION IN CLASS A PENICILLIN-BINDING PROTEINS [Streptococcus pneumoniae R6]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P76577	6.03e-83	2	625	141	761	Penicillin-binding protein 1C OS=Escherichia coli (strain K12) OX=83333 GN=pbpC PE=1 SV=1
P38050	8.72e-25	4	463	148	635	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
Q9KUC0	2.75e-22	4	415	261	707	Penicillin-binding protein 1B OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=mrcB PE=3 SV=1
P70997	6.53e-20	3	395	154	580	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
Q891X1	1.32e-19	1	481	162	706	Penicillin-binding protein 1A OS=Clostridium tetani (strain Massachusetts / E88) OX=212717 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000055	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000004187_00864.