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CAZyme Information: MGYG000004224_00713

You are here: Home > Sequence: MGYG000004224_00713

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; UBA1390; UBA1390;
CAZyme ID MGYG000004224_00713
CAZy Family GH43
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
791 89307.87 5.2048
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000004224 2221068 MAG United Kingdom Europe
Gene Location Start: 10342;  End: 12717  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000004224_00713.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH43 467 736 7e-98 0.9924812030075187

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd08981 GH43_Bt1873-like 2.32e-169 464 746 1 280
Glycosyl hydrolase family 43 protein such as Bacteroides thetaiotaomicron BT_1873. This glycosyl hydrolase family 43 (GH43) subfamily includes Bacteroides thetaiotaomicron VPI-5482 endo-arabinase (Bt1873;BT_1873), as well as uncharacterized enzymes similar to those with beta-1,4-xylosidase (xylan 1,4-beta-xylosidase; EC 3.2.1.37), beta-1,3-xylosidase (EC 3.2.1.-), alpha-L-arabinofuranosidase (EC 3.2.1.55), arabinanase (EC 3.2.1.99), xylanase (EC 3.2.1.8), endo-alpha-L-arabinanase and galactan 1,3-beta-galactosidase (EC 3.2.1.145) activities. These are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many of the GH43 enzymes in this family may display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.
cd08175 G1PDH 1.18e-107 32 446 1 339
Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner. Glycerol-1-phosphate dehydrogenase (G1PDH) plays a role in the synthesis of phosphoglycerolipids in Gram-positive bacterial species. It catalyzes the reversibly reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in a NADH-dependent manner. Its activity requires a Ni++ ion. In Bacillus subtilis, it has been described as AraM gene in L-arabinose (ara) operon. AraM protein forms homodimer.
COG0371 GldA 1.49e-68 35 410 11 359
Glycerol dehydrogenase or related enzyme, iron-containing ADH family [Energy production and conversion].
pfam13685 Fe-ADH_2 1.50e-62 36 309 1 251
Iron-containing alcohol dehydrogenase.
cd08549 G1PDH_related 5.46e-55 35 384 4 322
Glycerol-1-phosphate dehydrogenase and related proteins. This family contains bacterial and archeal glycerol-1-phosphate dehydrogenase-like oxidoreductases. These proteins have similarity with glycerol-1-phosphate dehydrogenase (G1PDH) which plays a role in the synthesis of phosphoglycerolipids in gram-positive bacterial species. It catalyzes the reversibly reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in a NADH-dependent manner. Its activity requires Ni++ ion. It also contains archaeal Sn-glycerol-1-phosphate dehydrogenase (Gro1PDH) that plays an important role in the formation of the enantiomeric configuration of the glycerophosphate backbone (sn-glycerol-1-phosphate) of archaeal ether lipids.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
AFH64775.1 6.94e-114 462 748 2 280
AEI44682.1 6.94e-114 462 748 2 280
QMV44079.1 1.29e-107 462 746 3 279
BCZ48739.1 4.27e-103 465 748 4 285
ASN19388.1 6.21e-103 462 745 3 285

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
5C0P_A 5.72e-63 458 735 15 280
Thecrystal structure of endo-arabinase from Bacteroides thetaiotaomicron VPI-5482 [Bacteroides thetaiotaomicron VPI-5482]
5FB3_A 1.23e-22 35 319 13 271
Structureof glycerophosphate dehydrogenase in complex with NADPH [Pyrobaculum calidifontis JCM 11548],5FB3_B Structure of glycerophosphate dehydrogenase in complex with NADPH [Pyrobaculum calidifontis JCM 11548],5FB3_C Structure of glycerophosphate dehydrogenase in complex with NADPH [Pyrobaculum calidifontis JCM 11548],5FB3_D Structure of glycerophosphate dehydrogenase in complex with NADPH [Pyrobaculum calidifontis JCM 11548],5FB3_E Structure of glycerophosphate dehydrogenase in complex with NADPH [Pyrobaculum calidifontis JCM 11548],5FB3_F Structure of glycerophosphate dehydrogenase in complex with NADPH [Pyrobaculum calidifontis JCM 11548]
4RGQ_A 1.13e-21 118 408 103 368
Crystalstructure of the Methanocaldococcus jannaschii G1PDH with NADPH and DHAP [Methanocaldococcus jannaschii DSM 2661],4RGQ_B Crystal structure of the Methanocaldococcus jannaschii G1PDH with NADPH and DHAP [Methanocaldococcus jannaschii DSM 2661],4RGQ_C Crystal structure of the Methanocaldococcus jannaschii G1PDH with NADPH and DHAP [Methanocaldococcus jannaschii DSM 2661],4RGQ_D Crystal structure of the Methanocaldococcus jannaschii G1PDH with NADPH and DHAP [Methanocaldococcus jannaschii DSM 2661],4RGV_A Crystal structure of the Methanocaldococcus jannaschii G1PDH [Methanocaldococcus jannaschii DSM 2661],4RGV_B Crystal structure of the Methanocaldococcus jannaschii G1PDH [Methanocaldococcus jannaschii DSM 2661]
4RFL_A 1.18e-21 118 408 106 371
Crystalstructure of G1PDH with NADPH from Methanocaldococcus jannaschii [Methanocaldococcus jannaschii DSM 2661],4RFL_B Crystal structure of G1PDH with NADPH from Methanocaldococcus jannaschii [Methanocaldococcus jannaschii DSM 2661],4RFL_C Crystal structure of G1PDH with NADPH from Methanocaldococcus jannaschii [Methanocaldococcus jannaschii DSM 2661],4RFL_D Crystal structure of G1PDH with NADPH from Methanocaldococcus jannaschii [Methanocaldococcus jannaschii DSM 2661]
4QQS_A 7.74e-17 471 702 17 234
Crystalstructure of a thermostable family-43 glycoside hydrolase [Halothermothrix orenii H 168],4QQS_B Crystal structure of a thermostable family-43 glycoside hydrolase [Halothermothrix orenii H 168]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9KBR3 6.18e-51 22 444 15 394
Glycerol-1-phosphate dehydrogenase [NAD(P)+] OS=Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) OX=272558 GN=egsA PE=3 SV=1
Q65GC3 6.08e-44 22 446 15 384
Glycerol-1-phosphate dehydrogenase [NAD(P)+] OS=Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) OX=279010 GN=egsA PE=3 SV=1
Q5WL08 1.91e-41 32 451 22 385
Glycerol-1-phosphate dehydrogenase [NAD(P)+] OS=Alkalihalobacillus clausii (strain KSM-K16) OX=66692 GN=egsA PE=3 SV=1
B3EYN8 4.38e-41 10 392 3 401
Glycerol-1-phosphate dehydrogenase [NAD(P)+] OS=Geobacillus stearothermophilus OX=1422 GN=egsA PE=3 SV=2
A7Z7G4 2.65e-39 32 344 24 329
Glycerol-1-phosphate dehydrogenase [NAD(P)+] OS=Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42) OX=326423 GN=egsA PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000065 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000004224_00713.