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CAZyme Information: MGYG000004411_01253
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; TANB77; CAG-508; CAG-269; | |||||||||||
| CAZyme ID | MGYG000004411_01253 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Surfactin synthase subunit 1 | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 36093; End: 43559 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK12467 | PRK12467 | 0.0 | 9 | 2068 | 52 | 2160 | peptide synthase; Provisional |
| PRK05691 | PRK05691 | 0.0 | 13 | 2068 | 682 | 2772 | peptide synthase; Validated |
| PRK12316 | PRK12316 | 0.0 | 390 | 2068 | 1936 | 3619 | peptide synthase; Provisional |
| PRK12467 | PRK12467 | 5.49e-177 | 1045 | 2071 | 34 | 1097 | peptide synthase; Provisional |
| cd17643 | A_NRPS_Cytc1-like | 9.03e-173 | 471 | 950 | 1 | 450 | similar to adenylation domain of cytotrienin synthetase CytC1. This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QND46664.1 | 2.22e-217 | 202 | 2042 | 754 | 2632 |
| BAY30132.1 | 2.95e-154 | 192 | 1032 | 318 | 1177 |
| BAZ00088.1 | 1.47e-152 | 192 | 1032 | 318 | 1175 |
| BAZ75991.1 | 1.47e-152 | 192 | 1032 | 318 | 1175 |
| BAY90071.1 | 1.67e-150 | 192 | 1045 | 317 | 1187 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6MFZ_A | 5.12e-246 | 454 | 2075 | 202 | 1801 | Crystalstructure of dimodular LgrA in a condensation state [Brevibacillus parabrevis],6MFZ_B Crystal structure of dimodular LgrA in a condensation state [Brevibacillus parabrevis] |
| 6MFY_A | 3.35e-233 | 454 | 1987 | 202 | 1715 | Crystalstructure of a 5-domain construct of LgrA in the substrate donation state [Brevibacillus parabrevis],6MG0_A Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis],6MG0_B Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis] |
| 5U89_A | 8.24e-148 | 436 | 1483 | 4 | 1070 | Crystalstructure of a cross-module fragment from the dimodular NRPS DhbF [Geobacillus sp. Y4.1MC1] |
| 6MFW_A | 4.44e-135 | 454 | 1442 | 202 | 1168 | Crystalstructure of a 4-domain construct of LgrA in the substrate donation state [Brevibacillus parabrevis] |
| 6MFX_A | 1.48e-134 | 454 | 1442 | 202 | 1168 | Crystalstructure of a 4-domain construct of a mutant of LgrA in the substrate donation state [Brevibacillus parabrevis] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P27206 | 0.0 | 7 | 2076 | 6 | 2086 | Surfactin synthase subunit 1 OS=Bacillus subtilis (strain 168) OX=224308 GN=srfAA PE=1 SV=4 |
| O68008 | 0.0 | 2 | 2069 | 4 | 2061 | Bacitracin synthase 3 OS=Bacillus licheniformis OX=1402 GN=bacC PE=3 SV=1 |
| O68007 | 0.0 | 7 | 2077 | 76 | 2135 | Bacitracin synthase 2 OS=Bacillus licheniformis OX=1402 GN=bacB PE=3 SV=1 |
| P39845 | 0.0 | 3 | 2068 | 2 | 2074 | Plipastatin synthase subunit A OS=Bacillus subtilis (strain 168) OX=224308 GN=ppsA PE=1 SV=2 |
| O30409 | 7.81e-319 | 1 | 2068 | 2087 | 4143 | Tyrocidine synthase 3 OS=Brevibacillus parabrevis OX=54914 GN=tycC PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.999171 | 0.000842 | 0.000022 | 0.000002 | 0.000001 | 0.000003 |