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CAZyme Information: MGYG000004443_01586
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Coprobacteraceae; ; | |||||||||||
| CAZyme ID | MGYG000004443_01586 | |||||||||||
| CAZy Family | GH101 | |||||||||||
| CAZyme Description | Endo-alpha-N-acetylgalactosaminidase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 7293; End: 10667 Strand: - | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH101 | 196 | 706 | 3.1e-111 | 0.801980198019802 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam12905 | Glyco_hydro_101 | 3.93e-91 | 415 | 677 | 1 | 273 | Endo-alpha-N-acetylgalactosaminidase. Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolize the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein Endo-alpha-N-acetylgalactosaminidase, where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor. |
| cd14244 | GH_101_like | 1.38e-84 | 427 | 695 | 1 | 293 | Endo-a-N-acetylgalactosaminidase and related glcyosyl hydrolases. This family contains the enzymatically active domain of cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins (EC:3.2.1.97). It has been classified as glycosyl hydrolase family 101 in the Cazy resource. Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae and other commensal human bacteria is largely determined by their ability to degrade host glycoproteins and to metabolize the resultant carbohydrates. |
| pfam18080 | Gal_mutarotas_3 | 2.31e-46 | 193 | 414 | 1 | 243 | Galactose mutarotase-like fold domain. This domain is found in endo-alpha-N-acetylgalactosaminidase present in Streptococcus pneumoniae. Endo-alpha-N-acetylgalactosaminidase is a cell surface-anchored glycoside hydrolase involved in the breakdown of mucin type O-linked glycans. The domain, known as domain 2, exhibits strong structural similarlity to the galactose mutarotase-like fold but lacks the active site residues. Domains, found in a number of glycoside hydrolases, structurally similar to domain 2 confer stability to the multidomain architectures. |
| pfam17974 | GalBD_like | 6.56e-16 | 964 | 1068 | 1 | 125 | Galactose-binding domain-like. Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase, phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va, membrane-anchored ephrin for the Eph family of receptor tyrosine kinases, and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1. The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. |
| pfam02018 | CBM_4_9 | 5.49e-08 | 820 | 949 | 1 | 128 | Carbohydrate binding domain. This family includes diverse carbohydrate binding domains. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| ATP57185.1 | 0.0 | 47 | 1120 | 72 | 1130 |
| AZN39795.1 | 8.53e-275 | 47 | 1123 | 48 | 1150 |
| QHW33475.1 | 3.66e-258 | 58 | 1123 | 68 | 1210 |
| AQT69519.1 | 4.11e-218 | 189 | 1068 | 47 | 927 |
| ATD58436.1 | 1.27e-216 | 41 | 1123 | 533 | 1626 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6QFO_A | 4.66e-103 | 189 | 1124 | 8 | 1117 | EngBFDARPin Fusion 9b 3G124 [Bifidobacterium longum] |
| 6QEP_A | 3.79e-102 | 189 | 1124 | 8 | 1117 | EngBFDARPin Fusion 4b H14 [Bifidobacterium longum] |
| 2ZXQ_A | 4.76e-102 | 189 | 1124 | 23 | 1132 | Crystalstructure of endo-alpha-N-acetylgalactosaminidase from Bifidobacterium longum (EngBF) [Bifidobacterium longum] |
| 6QFK_A | 9.96e-102 | 192 | 1124 | 11 | 1117 | EngBFDARPin Fusion 4b G10 [Bifidobacterium longum] |
| 6QEV_B | 9.96e-102 | 192 | 1124 | 11 | 1117 | EngBFDARPin Fusion 4b B6 [Bifidobacterium longum] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| A9WNA0 | 1.14e-122 | 184 | 1068 | 43 | 974 | Putative endo-alpha-N-acetylgalactosaminidase OS=Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) OX=288705 GN=RSal33209_1326 PE=3 SV=2 |
| Q2MGH6 | 6.62e-93 | 53 | 1110 | 177 | 1388 | Endo-alpha-N-acetylgalactosaminidase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=SP_0368 PE=1 SV=1 |
| Q8DR60 | 6.62e-93 | 53 | 1110 | 177 | 1388 | Endo-alpha-N-acetylgalactosaminidase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=spr0328 PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000188 | 0.999186 | 0.000158 | 0.000164 | 0.000150 | 0.000136 |