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CAZyme Information: MGYG000004565_01242
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Peptostreptococcus stomatis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Peptostreptococcales; Peptostreptococcaceae; Peptostreptococcus; Peptostreptococcus stomatis | |||||||||||
| CAZyme ID | MGYG000004565_01242 | |||||||||||
| CAZy Family | GH73 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 998; End: 2347 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| COG1705 | FlgJ | 7.33e-53 | 5 | 169 | 42 | 198 | Flagellum-specific peptidoglycan hydrolase FlgJ [Cell wall/membrane/envelope biogenesis, Cell motility]. |
| cd02696 | MurNAc-LAA | 3.76e-29 | 171 | 346 | 1 | 172 | N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall. |
| NF038016 | sporang_Gsm | 4.49e-27 | 9 | 159 | 163 | 312 | sporangiospore maturation cell wall hydrolase GsmA. The peptidoglycan-hydrolyzing enzyme GsmA occurs in some sporangia-forming members of the Actinobacteria, such as Actinoplanes missouriensis, and is required for proper separation of spores. GsmA proteins have one or two SH3 domains N-terminal to the hydrolase domain. |
| smart00047 | LYZ2 | 1.93e-25 | 9 | 159 | 11 | 147 | Lysozyme subfamily 2. Eubacterial enzymes distantly related to eukaryotic lysozymes. |
| 235559 | PRK05684 | 1.94e-23 | 28 | 183 | 174 | 307 | flgJ flagellar assembly peptidoglycan hydrolase FlgJ. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| SOB72340.1 | 8.93e-67 | 2 | 347 | 3 | 433 |
| VEJ12477.1 | 8.42e-48 | 9 | 348 | 3 | 334 |
| CCW37489.1 | 8.42e-48 | 9 | 348 | 3 | 334 |
| AOF50716.1 | 8.42e-48 | 9 | 348 | 3 | 334 |
| ALP87212.1 | 8.42e-48 | 9 | 348 | 3 | 334 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 3QAY_A | 8.74e-57 | 170 | 351 | 2 | 180 | ChainA, Endolysin [Clostridium virus phiCD27],3QAY_B Chain B, Endolysin [Clostridium virus phiCD27],3QAY_C Chain C, Endolysin [Clostridium virus phiCD27],3QAY_D Chain D, Endolysin [Clostridium virus phiCD27] |
| 3FI7_A | 5.02e-24 | 4 | 159 | 28 | 183 | CrystalStructure of the autolysin Auto (Lmo1076) from Listeria monocytogenes, catalytic domain [Listeria monocytogenes EGD-e] |
| 3VWO_A | 1.01e-16 | 32 | 150 | 27 | 143 | Crystalstructure of peptidoglycan hydrolase mutant from Sphingomonas sp. A1 [Sphingomonas sp. A1] |
| 2ZYC_A | 1.25e-16 | 32 | 150 | 28 | 144 | ChainA, Peptidoglycan hydrolase FlgJ [Sphingomonas sp. A1] |
| 3K3T_A | 8.03e-16 | 32 | 150 | 28 | 144 | E185Amutant of peptidoglycan hydrolase from Sphingomonas sp. A1 [Sphingomonas sp. A1] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| O32083 | 8.31e-31 | 5 | 161 | 47 | 200 | Exo-glucosaminidase LytG OS=Bacillus subtilis (strain 168) OX=224308 GN=lytG PE=1 SV=1 |
| Q9KQ15 | 1.27e-14 | 9 | 157 | 164 | 313 | Peptidoglycan hydrolase FlgJ OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=flgJ PE=3 SV=2 |
| Q9X9J3 | 1.76e-14 | 7 | 147 | 161 | 299 | Peptidoglycan hydrolase FlgJ OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) OX=223926 GN=flgJ PE=3 SV=1 |
| Q2G222 | 3.71e-13 | 26 | 160 | 340 | 473 | N-acetylmuramoyl-L-alanine amidase domain-containing protein SAOUHSC_02979 OS=Staphylococcus aureus (strain NCTC 8325 / PS 47) OX=93061 GN=SAOUHSC_02979 PE=1 SV=1 |
| P58231 | 8.81e-13 | 32 | 154 | 175 | 295 | Peptidoglycan hydrolase FlgJ OS=Escherichia coli O157:H7 OX=83334 GN=flgJ PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000045 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |