logo
sublogo
You are browsing environment: HUMAN GUT
help

CAZyme Information: MGYG000004667_02306

You are here: Home > Sequence: MGYG000004667_02306

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Clostridium beijerinckii
Lineage Bacteria; Firmicutes_A; Clostridia; Clostridiales; Clostridiaceae; Clostridium; Clostridium beijerinckii
CAZyme ID MGYG000004667_02306
CAZy Family GH18
CAZyme Description Chitinase A1
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
599 MGYG000004667_51|CGC1 66271.29 5.8723
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000004667 6180974 Isolate United States North America
Gene Location Start: 15050;  End: 16849  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000004667_02306.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH18 35 424 2e-84 0.9527027027027027
CBM5 466 505 9.5e-18 0.975
CBM5 547 586 4.8e-17 0.975

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06548 GH18_chitinase 9.90e-119 38 420 1 322
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
smart00636 Glyco_18 1.43e-99 38 420 2 334
Glyco_18 domain.
COG3325 ChiA 1.58e-90 28 420 30 423
Chitinase, GH18 family [Carbohydrate transport and metabolism].
pfam00704 Glyco_hydro_18 1.31e-78 37 420 1 307
Glycosyl hydrolases family 18.
cd02872 GH18_chitolectin_chitotriosidase 2.66e-78 38 435 1 362
This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
AJG99219.1 0.0 1 599 1 590
AQS05579.1 0.0 1 599 1 602
CUU48457.1 0.0 1 596 1 605
ABR34978.1 0.0 1 599 1 599
QUF72020.1 0.0 1 599 1 599

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
6BT9_A 2.92e-73 27 420 33 448
ChitinaseChiA74 from Bacillus thuringiensis [Bacillus thuringiensis],6BT9_B Chitinase ChiA74 from Bacillus thuringiensis [Bacillus thuringiensis]
1ITX_A 3.59e-62 25 420 1 406
ChainA, Glycosyl Hydrolase [Niallia circulans]
6KST_A 9.31e-51 38 435 9 370
Crystalstructure of the catalytic domain of chitinase ChiL from Chitiniphilus shinanonensis (CsChiL) [Chitiniphilus shinanonensis],6KST_B Crystal structure of the catalytic domain of chitinase ChiL from Chitiniphilus shinanonensis (CsChiL) [Chitiniphilus shinanonensis],6KXL_A Crystal structure of the catalytic domain of Chitiniphilus shinanonensis chitinase ChiL (CsChiL) complexed with N,N'-diacetylchitobiose [Chitiniphilus shinanonensis],6KXL_B Crystal structure of the catalytic domain of Chitiniphilus shinanonensis chitinase ChiL (CsChiL) complexed with N,N'-diacetylchitobiose [Chitiniphilus shinanonensis]
6KXM_A 4.80e-50 38 435 9 370
Crystalstructure of D157N mutant of Chitiniphilus shinanonensis chitinase ChiL (CsChiL) complexed with N,N'-diacetylchitobiose [Chitiniphilus shinanonensis],6KXM_B Crystal structure of D157N mutant of Chitiniphilus shinanonensis chitinase ChiL (CsChiL) complexed with N,N'-diacetylchitobiose [Chitiniphilus shinanonensis]
6IGY_A 6.01e-49 29 437 9 378
Crystalstructure of Aspergillus niger chitinase B [Aspergillus niger]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P20533 3.07e-60 2 441 6 458
Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1
A5FB63 3.20e-49 29 430 18 456
Chitinase ChiA OS=Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101) OX=376686 GN=chiA PE=1 SV=1
P32470 1.56e-46 40 418 42 381
Chitinase 1 OS=Aphanocladium album OX=12942 GN=CHI1 PE=1 SV=2
P32823 2.61e-46 26 589 141 818
Chitinase A OS=Pseudoalteromonas piscicida OX=43662 GN=chiA PE=1 SV=1
E9QRF2 9.71e-46 30 437 37 406
Endochitinase B1 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=chiB1 PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.605156 0.386981 0.005931 0.000452 0.000322 0.001159

TMHMM  Annotations      download full data without filtering help

start end
9 26