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CAZyme Information: MGYG000004714_01079
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Clostridiales; Clostridiaceae; Clostridium_X; | |||||||||||
| CAZyme ID | MGYG000004714_01079 | |||||||||||
| CAZy Family | CBM50 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 62; End: 3631 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| COG0791 | Spr | 4.36e-27 | 1056 | 1175 | 62 | 183 | Cell wall-associated hydrolase, NlpC family [Cell wall/membrane/envelope biogenesis]. |
| pfam00877 | NLPC_P60 | 8.37e-27 | 1081 | 1179 | 1 | 96 | NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins. |
| cd06583 | PGRP | 1.50e-23 | 14 | 141 | 1 | 124 | Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 kDa) extracellular proteins; intermediate PGRPs (PGRP-I) that are 40-45 kDa and are predicted to be transmembrane proteins; and long PGRPs (PGRP-L), up to 90 kDa, which may be either intracellular or transmembrane. Several structures of PGRPs are known in insects and mammals, some bound with substrates like Muramyl Tripeptide (MTP) or Tracheal Cytotoxin (TCT). The substrate binding site is conserved in PGRP-LCx, PGRP-LE, and PGRP-Ialpha proteins. This family includes Zn-dependent N-Acetylmuramoyl-L-alanine Amidase, EC:3.5.1.28. This enzyme cleaves the amide bond between N-acetylmuramoyl and L-amino acids, preferentially D-lactyl-L-Ala, in bacterial cell walls. The structure for the bacteriophage T7 lysozyme shows that two of the conserved histidines and a cysteine are zinc binding residues. Site-directed mutagenesis of T7 lysozyme indicates that two conserved residues, a Tyr and a Lys, are important for amidase activity. |
| NF033742 | NlpC_p60_RipB | 1.12e-22 | 1069 | 1179 | 73 | 196 | NlpC/P60 family peptidoglycan endopeptidase RipB. |
| pfam01510 | Amidase_2 | 6.89e-22 | 15 | 140 | 2 | 119 | N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| AQM60290.1 | 4.25e-119 | 416 | 1066 | 47 | 722 |
| QLY80841.1 | 1.48e-109 | 2 | 809 | 56 | 930 |
| SQI04537.1 | 1.32e-102 | 342 | 1103 | 119 | 914 |
| BAB80937.1 | 7.72e-98 | 235 | 1103 | 23 | 909 |
| ADA00360.1 | 7.72e-98 | 235 | 1103 | 23 | 909 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 3HMB_A | 2.30e-23 | 6 | 158 | 17 | 156 | ChainA, N-acetylmuramoyl-L-alanine amidase xlyA [Bacillus subtilis],3HMB_B Chain B, N-acetylmuramoyl-L-alanine amidase xlyA [Bacillus subtilis],3HMB_C Chain C, N-acetylmuramoyl-L-alanine amidase xlyA [Bacillus subtilis] |
| 7CFL_A | 1.18e-22 | 1072 | 1188 | 17 | 138 | ChainA, Putative cell wall hydrolase phosphatase-associated protein [Clostridioides difficile],7CFL_B Chain B, Putative cell wall hydrolase phosphatase-associated protein [Clostridioides difficile],7CFL_C Chain C, Putative cell wall hydrolase phosphatase-associated protein [Clostridioides difficile],7CFL_D Chain D, Putative cell wall hydrolase phosphatase-associated protein [Clostridioides difficile] |
| 3RDR_A | 2.74e-22 | 6 | 158 | 17 | 156 | Structureof the catalytic domain of XlyA [Bacillus subtilis] |
| 6B8C_A | 1.06e-21 | 1066 | 1177 | 25 | 134 | Crystalstructure of NlpC/p60 domain of peptidoglycan hydrolase SagA [Enterococcus faecium] |
| 3H41_A | 7.81e-15 | 1071 | 1188 | 191 | 310 | CRYSTALSTRUCTURE OF A NLPC/P60 FAMILY PROTEIN (BCE_2878) FROM BACILLUS CEREUS ATCC 10987 AT 1.79 A RESOLUTION [Bacillus cereus ATCC 10987] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| O32041 | 1.20e-22 | 654 | 968 | 26 | 312 | Putative N-acetylmuramoyl-L-alanine amidase YrvJ OS=Bacillus subtilis (strain 168) OX=224308 GN=yrvJ PE=3 SV=1 |
| P39800 | 4.62e-21 | 6 | 163 | 14 | 158 | N-acetylmuramoyl-L-alanine amidase XlyA OS=Bacillus subtilis (strain 168) OX=224308 GN=xlyA PE=1 SV=1 |
| P54450 | 1.70e-19 | 10 | 165 | 18 | 161 | N-acetylmuramoyl-L-alanine amidase CwlH OS=Bacillus subtilis (strain 168) OX=224308 GN=cwlH PE=1 SV=1 |
| P13692 | 3.16e-17 | 1066 | 1177 | 399 | 508 | Protein P54 OS=Enterococcus faecium OX=1352 PE=3 SV=2 |
| O35010 | 2.22e-16 | 1062 | 1174 | 166 | 278 | Gamma-D-glutamyl-L-lysine dipeptidyl-peptidase OS=Bacillus subtilis (strain 168) OX=224308 GN=ykfC PE=1 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000046 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |