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CAZyme Information: MGYG000004748_00992
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; | |||||||||||
| CAZyme ID | MGYG000004748_00992 | |||||||||||
| CAZy Family | GH10 | |||||||||||
| CAZyme Description | Choline-sulfatase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 344072; End: 345691 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd16030 | iduronate-2-sulfatase | 0.0 | 31 | 518 | 1 | 435 | iduronate-2-sulfatase. Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome. |
| cd16031 | G6S_like | 4.40e-82 | 31 | 529 | 1 | 426 | unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS). N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. |
| cd16033 | sulfatase_like | 1.62e-79 | 33 | 532 | 1 | 405 | uncharacterized sulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. |
| cd16027 | SGSH | 3.02e-75 | 33 | 532 | 1 | 371 | N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase). N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities. |
| cd16037 | sulfatase_like | 3.59e-75 | 33 | 506 | 1 | 320 | uncharacterized sulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| AOE12942.1 | 8.68e-154 | 8 | 536 | 7 | 517 |
| CCG00654.1 | 8.68e-154 | 8 | 536 | 7 | 517 |
| ANQ52496.2 | 3.01e-150 | 6 | 537 | 6 | 514 |
| QWG04788.1 | 3.01e-150 | 6 | 537 | 6 | 514 |
| AOE10594.1 | 8.63e-150 | 28 | 536 | 23 | 517 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6HHM_A | 1.98e-88 | 29 | 538 | 13 | 465 | Crystalstructure of the family S1_7 ulvan-specific sulfatase FA22070 from Formosa agariphila [Formosa agariphila] |
| 5FQL_A | 4.99e-85 | 26 | 515 | 5 | 513 | Insightsinto Hunter syndrome from the structure of iduronate-2- sulfatase [Homo sapiens] |
| 6IOZ_A | 1.12e-84 | 34 | 515 | 5 | 505 | Structuralinsights of idursulfase beta [Homo sapiens] |
| 4UG4_A | 1.27e-38 | 32 | 517 | 8 | 437 | ChainA, Choline Sulfatase [Sinorhizobium meliloti],4UG4_B Chain B, Choline Sulfatase [Sinorhizobium meliloti],4UG4_C Chain C, Choline Sulfatase [Sinorhizobium meliloti],4UG4_D Chain D, Choline Sulfatase [Sinorhizobium meliloti],4UG4_E Chain E, Choline Sulfatase [Sinorhizobium meliloti],4UG4_F Chain F, Choline Sulfatase [Sinorhizobium meliloti],4UG4_G Chain G, Choline Sulfatase [Sinorhizobium meliloti],4UG4_H Chain H, Choline Sulfatase [Sinorhizobium meliloti] |
| 6G5Z_A | 2.97e-38 | 32 | 517 | 1 | 430 | ChainA, Choline-sulfatase [Sinorhizobium meliloti],6G5Z_B Chain B, Choline-sulfatase [Sinorhizobium meliloti],6G5Z_C Chain C, Choline-sulfatase [Sinorhizobium meliloti],6G5Z_D Chain D, Choline-sulfatase [Sinorhizobium meliloti],6G60_A Choline sulfatase from Ensifer (Sinorhizobium) meliloti cocrystalized with choline [Sinorhizobium meliloti 1021],6G60_B Choline sulfatase from Ensifer (Sinorhizobium) meliloti cocrystalized with choline [Sinorhizobium meliloti 1021],6G60_C Choline sulfatase from Ensifer (Sinorhizobium) meliloti cocrystalized with choline [Sinorhizobium meliloti 1021],6G60_D Choline sulfatase from Ensifer (Sinorhizobium) meliloti cocrystalized with choline [Sinorhizobium meliloti 1021] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| T2KM04 | 9.33e-108 | 5 | 525 | 8 | 461 | Ulvan-active sulfatase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_22000 PE=1 SV=1 |
| T2KPK5 | 1.56e-87 | 29 | 538 | 26 | 478 | Ulvan-active sulfatase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_22070 PE=1 SV=2 |
| P22304 | 5.22e-84 | 26 | 515 | 30 | 538 | Iduronate 2-sulfatase OS=Homo sapiens OX=9606 GN=IDS PE=1 SV=1 |
| Q08890 | 2.99e-83 | 27 | 526 | 33 | 551 | Iduronate 2-sulfatase OS=Mus musculus OX=10090 GN=Ids PE=2 SV=3 |
| T2KMG4 | 2.13e-63 | 9 | 526 | 11 | 463 | Sulfatase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_22030 PE=1 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000078 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |