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CAZyme Information: MGYG000004797_03243
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Phocaeicola sartorii | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Phocaeicola; Phocaeicola sartorii | |||||||||||
| CAZyme ID | MGYG000004797_03243 | |||||||||||
| CAZy Family | CBM50 | |||||||||||
| CAZyme Description | Integration host factor subunit alpha | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 22638; End: 24059 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam00216 | Bac_DNA_binding | 3.21e-19 | 6 | 93 | 1 | 88 | Bacterial DNA-binding protein. |
| COG0776 | HimA | 6.29e-17 | 4 | 96 | 1 | 93 | Bacterial nucleoid DNA-binding protein [Replication, recombination and repair]. |
| cd13831 | HU | 4.05e-16 | 8 | 91 | 3 | 86 | histone-like DNA-binding protein HU. This subfamily includes HU and HU-like domains. HU is a conserved nucleoid-associated protein (NAP) which binds non-specifically to duplex DNA with a particular preference for targeting nicked and bent DNA. It is highly basic and contributes to chromosomal compaction and maintenance of negative supercoiling, thus often referred to as histone-like protein. HU can induce DNA bends, condense DNA in a fiber and also interact with single stranded DNA. It contains two homologous subunits, alpha and beta, typically forming homodimers (alpha-alpha and beta-beta), except in E. coli and other enterobacteria, which form heterodimers (alpha-beta). In E. coli, HU binds uniformly to the chromosome, with a preference for damaged or distorted DNA structures and can introduce negative supercoils into closed circular DNA in the presence of topoisomerase I. Anabaena HU (AHU) shows preference for A/T-rich region in the center of its DNA binding site. |
| smart00411 | BHL | 6.39e-16 | 5 | 94 | 1 | 90 | bacterial (prokaryotic) histone like domain. |
| cd13832 | IHF | 1.15e-14 | 9 | 91 | 3 | 85 | Integration host factor (IHF) and similar proteins. This subfamily includes integration host factor (IHF) and IHF-like domains. IHF is a nucleoid-associated protein (NAP) that binds and sharply bends many DNA targets in a sequence specific manner. It is a heterodimeric protein composed of two highly homologous subunits IHFA (IHF-alpha) and IHFB (IHF-beta). It is known to act as a transcription factor at many gene regulatory regions in E. coli. IHF is an essential cofactor in phage lambda site-specific recombination, having an architectural role during assembly of specialized nucleoprotein structures (snups). IHF is also involved in formation as well as maintenance of bacterial biofilms since it is found in complex with extracellular DNA (eDNA) within the extracellular polymeric substances (EPS) matrix of many biofilms. This subfamily also includes the protein Hbb from tick-borne spirochete Borrelia burgdorferi, responsible for causing Lyme disease in humans. Hbb, a homodimer, shows DNA sequence preferences that are related, yet distinct from those of IHF. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QQY44100.1 | 9.96e-247 | 1 | 473 | 1 | 476 |
| QTO24926.1 | 6.36e-78 | 1 | 472 | 1 | 471 |
| QMW87934.1 | 6.91e-78 | 1 | 470 | 1 | 485 |
| QQA06541.1 | 6.91e-78 | 1 | 470 | 1 | 485 |
| QQR17553.1 | 8.51e-78 | 1 | 470 | 1 | 442 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 5EKA_A | 4.33e-10 | 5 | 95 | 6 | 96 | HUDNA-binding protein from Thermus thermophilus [Thermus thermophilus HB8] |
| 5LVT_A | 9.72e-10 | 8 | 93 | 5 | 90 | Structureof HU protein from Lactococcus lactis [Lactococcus lactis subsp. lactis Il1403],5LVT_B Structure of HU protein from Lactococcus lactis [Lactococcus lactis subsp. lactis Il1403],5LVT_C Structure of HU protein from Lactococcus lactis [Lactococcus lactis subsp. lactis Il1403],5LVT_D Structure of HU protein from Lactococcus lactis [Lactococcus lactis subsp. lactis Il1403] |
| 1HUE_A | 6.17e-09 | 9 | 93 | 5 | 89 | ChainA, HU PROTEIN [Geobacillus stearothermophilus],1HUE_B Chain B, HU PROTEIN [Geobacillus stearothermophilus],1HUU_A Dna-Binding Protein Hu From Bacillus Stearothermophilus [Geobacillus stearothermophilus],1HUU_B Dna-Binding Protein Hu From Bacillus Stearothermophilus [Geobacillus stearothermophilus],1HUU_C Dna-Binding Protein Hu From Bacillus Stearothermophilus [Geobacillus stearothermophilus] |
| 4QJN_A | 1.41e-08 | 9 | 93 | 5 | 89 | ChainA, DNA-binding protein HU [Staphylococcus aureus subsp. aureus Mu50],4QJN_B Chain B, DNA-binding protein HU [Staphylococcus aureus subsp. aureus Mu50],4QJN_C Chain C, DNA-binding protein HU [Staphylococcus aureus subsp. aureus Mu50],4QJN_D Chain D, DNA-binding protein HU [Staphylococcus aureus subsp. aureus Mu50],4QJU_A Chain A, DNA-binding protein HU [Staphylococcus aureus subsp. aureus Mu50],4QJU_B Chain B, DNA-binding protein HU [Staphylococcus aureus subsp. aureus Mu50] |
| 5FBM_A | 1.97e-08 | 8 | 93 | 5 | 90 | CrystalStructure of Histone Like Protein (HLP) from Streptococcus mutans Refined to 1.9 A Resolution [Streptococcus mutans UA159],5FBM_B Crystal Structure of Histone Like Protein (HLP) from Streptococcus mutans Refined to 1.9 A Resolution [Streptococcus mutans UA159] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P05385 | 1.94e-11 | 9 | 95 | 5 | 91 | DNA-binding protein HU OS=Clostridium pasteurianum OX=1501 GN=hup PE=1 SV=1 |
| A7HBJ3 | 6.07e-11 | 5 | 94 | 1 | 90 | Integration host factor subunit alpha OS=Anaeromyxobacter sp. (strain Fw109-5) OX=404589 GN=ihfA PE=3 SV=1 |
| A6VYH5 | 1.51e-10 | 5 | 93 | 4 | 92 | Integration host factor subunit alpha OS=Marinomonas sp. (strain MWYL1) OX=400668 GN=ihfA PE=3 SV=1 |
| B4UAP1 | 2.20e-10 | 5 | 94 | 1 | 90 | Integration host factor subunit alpha OS=Anaeromyxobacter sp. (strain K) OX=447217 GN=ihfA PE=3 SV=1 |
| B8J836 | 2.20e-10 | 5 | 94 | 1 | 90 | Integration host factor subunit alpha OS=Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258) OX=455488 GN=ihfA PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000086 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
