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CAZyme Information: MGYG000004816_00954
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Phascolarctobacterium_A sp900757795 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_C; Negativicutes; Acidaminococcales; Acidaminococcaceae; Phascolarctobacterium_A; Phascolarctobacterium_A sp900757795 | |||||||||||
| CAZyme ID | MGYG000004816_00954 | |||||||||||
| CAZy Family | GT30 | |||||||||||
| CAZyme Description | Tetraacyldisaccharide 4'-kinase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 53869; End: 56403 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GT30 | 51 | 217 | 6.5e-55 | 0.9322033898305084 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK05749 | PRK05749 | 3.74e-120 | 1 | 432 | 2 | 422 | 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed |
| COG1519 | KdtA | 6.47e-109 | 1 | 431 | 1 | 419 | 3-deoxy-D-manno-octulosonic-acid transferase [Cell wall/membrane/envelope biogenesis]. |
| pfam02606 | LpxK | 6.44e-87 | 485 | 838 | 1 | 318 | Tetraacyldisaccharide-1-P 4'-kinase. This family consists of tetraacyldisaccharide-1-P 4'-kinase also known as Lipid-A 4'-kinase or Lipid A biosynthesis protein LpxK, EC:2.7.1.130. This enzyme catalyzes the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D -glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glu cosam inyl beta-phosphate <=> ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D- glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate. This enzyme is involved in the synthesis of lipid A portion of the bacterial lipopolysaccharide layer (LPS). The family contains a P-loop motif at the N-terminus. |
| PRK00652 | lpxK | 1.95e-69 | 482 | 801 | 12 | 295 | tetraacyldisaccharide 4'-kinase; Reviewed |
| pfam04413 | Glycos_transf_N | 4.11e-66 | 53 | 217 | 12 | 176 | 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase). Members of this family transfer activated sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. Members of the family transfer UDP, ADP, GDP or CMP linked sugars. The Glycos_transf_N region is flanked at the N-terminus by a signal peptide and at the C-terminus by Glycos_transf_1 (pfam00534). The eukaryotic glycogen synthases may be distant members of this bacterial family. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QTV78313.1 | 0.0 | 1 | 844 | 1 | 843 |
| QNP77900.1 | 0.0 | 1 | 840 | 1 | 839 |
| BBG63225.1 | 0.0 | 1 | 840 | 1 | 839 |
| AEQ21866.1 | 0.0 | 1 | 840 | 1 | 839 |
| ADB48040.1 | 0.0 | 1 | 840 | 1 | 839 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4EHX_A | 1.53e-41 | 493 | 770 | 10 | 264 | Crystalstructure of LpxK from Aquifex aeolicus at 1.9 angstrom resolution [Aquifex aeolicus VF5],4EHY_A Crystal structure of LpxK from Aquifex aeolicus in complex with ADP/Mg2+ at 2.2 angstrom resolution [Aquifex aeolicus VF5],4ITL_A Crystal structure of LpxK from Aquifex aeolicus in complex with AMP-PCP at 2.1 angstrom resolution [Aquifex aeolicus VF5],4ITM_A Crystal structure of 'apo' form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution [Aquifex aeolicus VF5],4ITN_A Crystal structure of 'compact P-loop' LpxK from Aquifex aeolicus in complex with chloride at 2.2 angstrom resolution [Aquifex aeolicus VF5],4LKV_A Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK [Aquifex aeolicus VF5],4LKV_B Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK [Aquifex aeolicus VF5],4LKV_C Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK [Aquifex aeolicus VF5],4LKV_D Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK [Aquifex aeolicus VF5] |
| 4EHW_A | 1.61e-41 | 493 | 770 | 12 | 266 | Crystalstructure of LpxK from Aquifex aeolicus at 2.3 angstrom resolution [Aquifex aeolicus VF5] |
| 2XCI_A | 7.53e-35 | 54 | 396 | 40 | 344 | Membrane-embeddedmonofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form [Aquifex aeolicus],2XCI_B Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form [Aquifex aeolicus],2XCI_C Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form [Aquifex aeolicus],2XCI_D Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form [Aquifex aeolicus],2XCU_A Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, complex with CMP [Aquifex aeolicus],2XCU_B Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, complex with CMP [Aquifex aeolicus],2XCU_C Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, complex with CMP [Aquifex aeolicus],2XCU_D Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, complex with CMP [Aquifex aeolicus] |
| 4BFC_A | 1.29e-14 | 242 | 419 | 44 | 219 | ChainA, 3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE [Acinetobacter baumannii] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| B8CZC3 | 1.57e-66 | 484 | 827 | 28 | 376 | Tetraacyldisaccharide 4'-kinase OS=Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) OX=373903 GN=lpxK PE=3 SV=1 |
| Q2LVL1 | 3.15e-66 | 488 | 800 | 26 | 338 | Tetraacyldisaccharide 4'-kinase OS=Syntrophus aciditrophicus (strain SB) OX=56780 GN=lpxK PE=3 SV=1 |
| B8F928 | 2.31e-61 | 475 | 838 | 15 | 365 | Tetraacyldisaccharide 4'-kinase OS=Desulfatibacillum aliphaticivorans OX=218208 GN=lpxK PE=3 SV=1 |
| P44806 | 1.45e-59 | 57 | 432 | 53 | 424 | 3-deoxy-D-manno-octulosonic acid transferase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) OX=71421 GN=waaA PE=1 SV=1 |
| A7HDI5 | 1.67e-59 | 485 | 839 | 20 | 362 | Tetraacyldisaccharide 4'-kinase OS=Anaeromyxobacter sp. (strain Fw109-5) OX=404589 GN=lpxK PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.999997 | 0.000036 | 0.000003 | 0.000000 | 0.000000 | 0.000002 |
