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CAZyme Information: MGYG000004824_01398
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Paraprevotella; | |||||||||||
| CAZyme ID | MGYG000004824_01398 | |||||||||||
| CAZy Family | GH23 | |||||||||||
| CAZyme Description | Membrane-bound lytic murein transglycosylase F | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 47183; End: 48454 Strand: - | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH23 | 218 | 372 | 2.1e-29 | 0.8222222222222222 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd13403 | MLTF-like | 1.22e-76 | 213 | 376 | 1 | 160 | membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins. This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. |
| PRK10859 | PRK10859 | 2.33e-54 | 49 | 379 | 36 | 450 | membrane-bound lytic murein transglycosylase MltF. |
| COG4623 | MltF | 5.34e-51 | 48 | 379 | 15 | 431 | Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms]. |
| cd13401 | Slt70-like | 1.81e-29 | 209 | 376 | 6 | 150 | 70kDa soluble lytic transglycosylase (Slt70) and similar proteins. Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda. |
| cd16896 | LT_Slt70-like | 2.49e-27 | 226 | 314 | 21 | 110 | uncharacterized lytic transglycosylase subfamily with similarity to Slt70. Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QUB48180.1 | 6.24e-127 | 6 | 393 | 5 | 383 |
| VEH15587.1 | 1.10e-116 | 11 | 392 | 39 | 412 |
| EFC70077.2 | 4.93e-113 | 7 | 390 | 5 | 385 |
| ALO48082.1 | 2.71e-112 | 19 | 400 | 17 | 386 |
| QNT65891.1 | 1.33e-111 | 7 | 380 | 6 | 387 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4OYV_A | 6.68e-29 | 38 | 373 | 3 | 426 | Crystalstructure of MltF from Pseudomonas aeruginosa complexed with leucine [Pseudomonas aeruginosa PAO1] |
| 4OWD_A | 6.68e-29 | 38 | 373 | 3 | 426 | Crystalstructure of MltF from Pseudomonas aeruginosa complexed with cysteine [Pseudomonas aeruginosa PAO1],4OXV_A Crystal structure of MltF from Pseudomonas aeruginosa complexed with valine [Pseudomonas aeruginosa PADK2_CF510],4P0G_A Crystal structure of MltF from Pseudomonas aeruginosa complexed with bulgecin and muropeptide [Pseudomonas aeruginosa PAO1],4P11_A Native crystal structure of MltF Pseudomonas aeruginosa [Pseudomonas aeruginosa PAO1] |
| 5AA2_A | 1.29e-28 | 38 | 392 | 37 | 484 | Crystalstructure of MltF from Pseudomonas aeruginosa in complex with NAM-pentapeptide. [Pseudomonas aeruginosa BWHPSA013],5AA2_C Crystal structure of MltF from Pseudomonas aeruginosa in complex with NAM-pentapeptide. [Pseudomonas aeruginosa BWHPSA013] |
| 5AA2_B | 1.75e-28 | 38 | 392 | 37 | 484 | Crystalstructure of MltF from Pseudomonas aeruginosa in complex with NAM-pentapeptide. [Pseudomonas aeruginosa BWHPSA013] |
| 5AA1_A | 1.75e-28 | 38 | 392 | 37 | 484 | Crystalstructure of MltF from Pseudomonas aeruginosa in complex with NAG-anhNAM-pentapeptide [Pseudomonas aeruginosa BWHPSA013],5AA1_B Crystal structure of MltF from Pseudomonas aeruginosa in complex with NAG-anhNAM-pentapeptide [Pseudomonas aeruginosa BWHPSA013],5AA1_C Crystal structure of MltF from Pseudomonas aeruginosa in complex with NAG-anhNAM-pentapeptide [Pseudomonas aeruginosa BWHPSA013],5AA1_D Crystal structure of MltF from Pseudomonas aeruginosa in complex with NAG-anhNAM-pentapeptide [Pseudomonas aeruginosa BWHPSA013] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| A0KJ50 | 4.76e-33 | 49 | 373 | 40 | 451 | Membrane-bound lytic murein transglycosylase F OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049) OX=380703 GN=mltF PE=3 SV=1 |
| A7FFU9 | 2.82e-32 | 49 | 381 | 36 | 452 | Membrane-bound lytic murein transglycosylase F OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) OX=349747 GN=mltF PE=3 SV=1 |
| Q74SQ6 | 2.82e-32 | 49 | 381 | 36 | 452 | Membrane-bound lytic murein transglycosylase F OS=Yersinia pestis OX=632 GN=mltF PE=1 SV=1 |
| A9R413 | 2.82e-32 | 49 | 381 | 36 | 452 | Membrane-bound lytic murein transglycosylase F OS=Yersinia pestis bv. Antiqua (strain Angola) OX=349746 GN=mltF PE=3 SV=1 |
| B1JRW4 | 2.82e-32 | 49 | 381 | 36 | 452 | Membrane-bound lytic murein transglycosylase F OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) OX=502800 GN=mltF PE=3 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as LIPO
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000000 | 0.000005 | 1.000037 | 0.000000 | 0.000000 | 0.000000 |